{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T16:57:14Z","timestamp":1649177834746},"reference-count":10,"publisher":"LLC Obyedinennaya Redaktsiya","issue":"12","license":[{"start":{"date-parts":[[2017,12,15]],"date-time":"2017-12-15T00:00:00Z","timestamp":1513296000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Aim. To investigate the clinical and functional parameters in patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) versus those with chronic obstructive pulmonary disease (COPD) and asthma. Subjects and methods. A total of 129 people were examined. 51 patients with ACOS were followed up in Group 1; Group 2 included 38 patients with severe asthma; Group 3 consisted of 40 patients with severe COPD. All the patients underwent clinical examination: history data collection, physical examination, evaluation of disease symptoms, and study of respiratory function (spirometry, body plethysmography). Results. ACOS is clinically characterized by considerable demands for emergency drugs and by more frequent asthmatic fits and exacerbations, which require hospitalization. The parameters of bronchial resistance in ACOS were established to be increased throughout the follow-up period and to be comparable with those in patients with COPD. In the patients with ACOS, the severity of pulmonary hyperinflation was associated with increased demands for emergency drugs (r=0.59; p=0.015). Fixed bronchial obstruction in ACOS can be caused by smoking intensity and duration associated with increased bronchial resistance in expiration (r=0.51; p=0.003) and intrathoracic volume (r=0.71; p=0.0001); as well as increased body mass index (p<\/jats:p>","DOI":"10.17116\/terarkh2017891268-75","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T12:16:14Z","timestamp":1518005774000},"page":"68-75","source":"Crossref","is-referenced-by-count":2,"title":["ACOS: Clinical and functional features The Russian formulation mesalazine (kansalazine) in the therapy of ulcerative colitis"],"prefix":"10.26442","volume":"89","author":[{"given":"E A","family":"Sobko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S V","family":"Chubarova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I V","family":"Demko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M M","family":"Loktionova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O P","family":"Ishchenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I A","family":"Solovyeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A Yu","family":"Kraposhina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N V","family":"Gordeeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2017,12,15]]},"reference":[{"key":"key-10.17116\/terarkh2017891268-75-1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062985"},{"key":"key-10.17116\/terarkh2017891268-75-2","doi-asserted-by":"crossref","unstructured":"Ovcharenko S. Phenotypes of chronic obstructive pulmonary disease and the ECLIPSE study: preliminary results. Pul'monologiya. 2011;3:113-117. (In Russ.)","DOI":"10.18093\/0869-0189-2011-0-3-113-117"},{"key":"key-10.17116\/terarkh2017891268-75-3","unstructured":"Diagnosis of disease of chronic airflow limitation: asthma, COPD and asthma\u2014COPD overlap syndrome (ACOS). Accessed November 5, 2015. http:\/\/www.goldcopd.org\/asthma\u2014COPDoverlap.html"},{"key":"key-10.17116\/terarkh2017891268-75-4","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/861926"},{"key":"key-10.17116\/terarkh2017891268-75-5","unstructured":"Belevskii A. Overlap syndrome of asthma and chronic obstructive pulmonary disease (based on a joint working document GINA and GOLD expert groups. Prakticheskaya pul'monologiya. 2014;2:12-19. (In Russ.)"},{"key":"key-10.17116\/terarkh2017891268-75-6","doi-asserted-by":"crossref","unstructured":"Leshchenko I, Baranova I. Inflammatory biomarkers in chronic obstructive pulmonary disease. Pul'monologiya. 2012;2:108-117. (In Russ.)","DOI":"10.18093\/0869-0189-2012-0-2-108-117"},{"key":"key-10.17116\/terarkh2017891268-75-7","doi-asserted-by":"publisher","DOI":"10.12737\/20131"},{"key":"key-10.17116\/terarkh2017891268-75-8","unstructured":"Global Initiative for Chronic Obstructive Lung Disease Global strategy for the diagnosis, management, and prevention of COPD. 2014. Accessed October 20, 2014. http:\/\/www.goldcopd.org\/"},{"key":"key-10.17116\/terarkh2017891268-75-9","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2072-1439"},{"key":"key-10.17116\/terarkh2017891268-75-10","doi-asserted-by":"crossref","unstructured":"Tetenev K, Tetenev F, Ageyeva T, Bodrova T, Karzilov A, Mesko P. Mechanisms of counteracting flap-valve bronchial obstruction in case of obstructive pulmonary emphysema. Byulleten' sibirskoi meditsiny. 2015;4(14):75-81. (In Russ.)","DOI":"10.20538\/1682-0363-2015-4-75-81"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"deposited":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T20:33:32Z","timestamp":1603830812000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/32338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,15]]},"references-count":10,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2017,12,15]]}},"URL":"https:\/\/doi.org\/10.17116\/terarkh2017891268-75","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"value":"2309-5342","type":"electronic"},{"value":"0040-3660","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12,15]]}}}