{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:19:57Z","timestamp":1695489597020},"reference-count":26,"publisher":"Consilium Medicum","issue":"5","license":[{"start":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T00:00:00Z","timestamp":1494806400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Aim. To analyze polymorphism in the regulatory regions of the vascular endothelial growth factor (VEGF) gene in female patients with rheumatoid arthritis (RA). Subjects and methods. The investigation enrolled 257 female patients with RA. A control group consisted of 297 women without chronic diseases. The investigators examined the single-nucleotide polymorphism of VEGF-\u04102578\u0421 in the promoter region (rs699947) and that of VEGF+\u0421936\u0422 3 in the retranslated region (rs3025039) of the gene. Genotyping was performed by restriction fragment length polymorphism analysis. Results. There was an increase in the frequency of VEGF+936 CT and a reduction in that of the VEGF+936\u0421\u0421 genotypes in the seronegative patients as compared to the healthy women. The VEGF+936\u0421\u0421 genotype frequency was higher in the patients with seropositive RA than in the subgroup of seronegative patients. The frequency of the VEGF-2578\u0421\u0421 genotype was increased in the patients with RA and rheumatoid nodules, as compared to the healthy women. Conclusion. The data presented suggest that the presence of certain VEGF gene variants located in the regulatory regions may reflect the nature of immunopathological mechanisms in RA.<\/jats:p>","DOI":"10.17116\/terarkh201789560-64","type":"journal-article","created":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T16:38:04Z","timestamp":1497631084000},"page":"60-64","source":"Crossref","is-referenced-by-count":2,"title":["Polymorphism in the regulatory regions \u2013\u04212578A and +C936T of the vascular endothelial growth factor (VEGF-A) gene in Russian women with rheumatoid arthritis"],"prefix":"10.26442","volume":"89","author":[{"given":"A V","family":"Shevchenko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V F","family":"Prokofyev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Korolev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N E","family":"Banshchikova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V I","family":"Konenkov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2017,5,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/ar575"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200109)44:9<2055::AID-ART355>3.0.CO;2-2"},{"key":"ref3","unstructured":"Lee SS, Joo YS, Kim WU Min DJ, Min JK, Park SH, Cho CS, Kim HY. 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