{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:12:40Z","timestamp":1788844360279,"version":"build-2803163510"},"reference-count":0,"publisher":"The University of Kansas","issue":"3","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Serican J. Med."],"abstract":"<jats:p>Interleukin-17 (IL-17) receptor A (IL-17RA) promotes inflammatory reactions by activating kinases and transcription regulators. Our previous studies have demonstrated that glycogen synthase kinase 3 (GSK3) phosphorylates IL-17RA at T780. It is not known whether other kinases also phosphorylate IL-17RA. Here, we identified an association between dual\u2011specificity tyrosine-regulated kinases (DYRKs) and IL-17RA. We found that DYRK1B and DYRK4 interacted with and phosphorylated IL-17RA at serine 801 (S801). Overexpression of DYRK1B and DYRK4 enhanced IL-17RA phosphorylation, whereas siRNA-mediated knockdown of DYRK1B or DYRK4 reduced the phosphorylation. Serum starvation of the cultured cells increased expression levels of DYRK1B\/4 and IL-17RA phosphorylation, suggesting stress-dependent modulation of receptor modification. Moreover, selective small\u2011molecule inhibitors of DYRKs effectively suppressed IL-17RA phosphorylation at S801. Our findings indicate a link between DYRK family kinases and IL-17RA phosphorylation, providing new potential therapeutic targets in the management of IL-17-mediated diseases.<\/jats:p>","DOI":"10.17161\/sjm.v3i3.25722","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:00:32Z","timestamp":1788498032000},"source":"Crossref","is-referenced-by-count":0,"title":["DYRK kinases phosphorylate IL-17RA at S801"],"prefix":"10.17161","volume":"3","author":[{"given":"Sayed Ala","family":"Moududee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A.","family":"Herppich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Kay H.","family":"Pflum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxia","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongbing","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6672","published-online":{"date-parts":[[2026,8,28]]},"container-title":["Serican Journal of Medicine"],"original-title":[],"link":[{"URL":"https:\/\/journals.ku.edu\/sjm\/article\/download\/25722\/22901","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.ku.edu\/sjm\/article\/download\/25722\/22901","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:00:33Z","timestamp":1788843633000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.ku.edu\/sjm\/article\/view\/25722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,7,7]]}},"URL":"https:\/\/doi.org\/10.17161\/sjm.v3i3.25722","relation":{},"ISSN":["3066-3377"],"issn-type":[{"value":"3066-3377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]}}}