{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T14:22:33Z","timestamp":1794320553737,"version":"4.9.0"},"reference-count":0,"publisher":"Forschungsgesellschaft f\u00fcr Arbeitsphysiologie und Arbeitsschutz e.V.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EXCLI J."],"abstract":"<jats:p>Haemoglobin (Hb)-M Hyde Park, also known as Hb-M Akita is a rare type of hereditary Hb M due to autosomal dominant mutation of CAC&gt;TAC on codon 92 of \u03b2 globin gene resulting in the replacement of histidine by tyrosine on \u03b2 globin chain. This variant Hb has a tendency to form methaemoglobin (metHb). The iron ion in metHb is oxidized to ferric (Fe3+) which is unable to carry oxygen and the patients manifest as cyanosis clinically. A 9-year-old Malay girl was incidentally found to be cyanotic when she presented to a health clinic. Laboratory investigations revealed raised methaemoglobin levels and Hb analysis findings were consistent with Hb-M Hyde Park. \u03b2 gene sequencing confirmed a point mutation of CAC&gt;TAC on codon 92 in one of the \u03b2 genes. The family study done on the individuals with cyanosis showed similar findings. A diagnosis of heterozygous Hb-M Hyde Park was made. Patients with this variant Hb usually presented with cyanosis with mild haemolysis and maybe misdiagnosed as congenital heart disease. No further treatment is needed as patients are relatively asymptomatic. Although the disease is harmless in the heterozygous carriers but the offspring of the carriers may suffer severe haemolytic anaemia when the offspring also inherit other \u03b2 haemoglobinopathies\/thalassemia. This can happen due to high prevalence of \u03b2 thalassemia carrier (3.5-4 %) found in Malaysia. At the time of writing, this is the first case of hereditary Hb-M Hyde Park diagnosed in a Malay family living in Malaysia.<\/jats:p>","DOI":"10.17179\/excli2016-613","type":"journal-article","created":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T13:38:38Z","timestamp":1794317918000},"page":"630-635","source":"Crossref","is-referenced-by-count":0,"title":["First reported case of Haemoglobin-M Hyde Park in a Malay family living in Malaysia"],"prefix":"10.17179","volume":"15","author":[{"given":"Tang Yee","family":"Loong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris Lau Sie","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Rahman A.","family":"Jamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nor Azian Abdul","family":"Murad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja Zahratul Azma Raja","family":"Sabudin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leong Chooi","family":"Fun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"58771","published-online":{"date-parts":[[2016,11,7]]},"container-title":["EXCLI Journal"],"original-title":[],"link":[{"URL":"https:\/\/www.excli.de\/excli\/article\/download\/410\/1105","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.excli.de\/excli\/article\/download\/410\/1106","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.excli.de\/excli\/article\/download\/410\/1107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T13:38:50Z","timestamp":1794317930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.excli.de\/excli\/article\/view\/410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,7]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17179\/excli2016-613","relation":{"is-cited-by":[{"id-type":"doi","id":"10.5045\/br.2020.2020084","asserted-by":"object"}]},"ISSN":["1611-2156"],"issn-type":[{"value":"1611-2156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,7]]}}}