{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T17:47:58Z","timestamp":1792259278907,"version":"4.4.0"},"reference-count":0,"publisher":"Aurora Health Care, Inc.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Patient-Centered Research and Reviews"],"abstract":"<jats:p>Purpose: The Acute Leukemia Advocates Network (ALAN) sought to determine which factors are most associated with poor quality of life (QoL) in patients with acute leukemia and to determine key issues and unmet needs through administration of an online survey distributed worldwide via partner patient organizations.\nMethods: ALAN developed a questionnaire informed by literature review and based extensively on the hematological malignancy-specific patient-reported outcomes (HM-PRO) measure to assess the impact of acute leukemia on QoL and its relationships with patients\u2019 demographics, disease state, disease impact, and support from health care professionals. Univariate and multivariable statistical analysis was used to investigate relationships between HM-PRO scores and the other factors.\nResults: Of 552 respondents from 42 countries, 332 had acute myeloid leukemia, 139 had acute lymphoblastic leukemia, and 81 had acute promyelocytic leukemia (survey data collected in 2019). Younger age, female gender, and lower income were all significantly negatively associated with QoL. Weak or moderate correlations were observed between overall support, management, and impact of treatment and diagnosis of acute leukemia. Feeling isolated and having reduced ability to carry out physical or enjoyable activities were the most important individual factors, while the best predictors for QoL impact were age, gender, and income (model r2 = 0.16, complete case n = 449).\nConclusions: Findings indicated key factors, particularly age, gender, and socioeconomic state, that clinicians responsible for the care of patients with acute leukemia should be aware of when designing support strategies. The importance of social functioning in relation to patient QoL also should be included in considerations.<\/jats:p>","DOI":"10.17294\/2330-0698.1951","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T03:56:43Z","timestamp":1673927803000},"page":"21-30","source":"Crossref","is-referenced-by-count":21,"title":["Understanding Quality of Life in Patients With Acute Leukemia, a Global Survey"],"prefix":"10.17294","volume":"10","author":[{"given":"Zack","family":"Pemberton-Whiteley","sequence":"first","affiliation":[{"name":"Acute Leukemia Advocates Network; Leukaemia Care"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Nier","sequence":"additional","affiliation":[{"name":"Acute Leukemia Advocates Network"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Geissler","sequence":"additional","affiliation":[{"name":"Acute Leukemia Advocates Network; LeukaNET e.V."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Wintrich","sequence":"additional","affiliation":[{"name":"Acute Leukemia Advocates Network; MDS UK Patient Support Group"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bregje","family":"Verhoeven","sequence":"additional","affiliation":[{"name":"Acute Leukemia Advocates Network; Foundation Hematon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita O","family":"Christensen","sequence":"additional","affiliation":[{"name":"Acute Leukemia Advocates Network; LyLe Patientforeningenen for Lymfekr\u00e6ft Leuk\u00e6mi og MDS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Salek","sequence":"additional","affiliation":[{"name":"University of Hertfordshire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther Natalie","family":"Oliva","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Bianchi-Melacrino-Morelli"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana","family":"Ionova","sequence":"additional","affiliation":[{"name":"National Medical Surgical Centre and Multinational Centre for Quality of Life Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennie","family":"Bradley","sequence":"additional","affiliation":[{"name":"Quality Health Ltd, an IQVIA company"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6854","published-online":{"date-parts":[[2023,1,17]]},"container-title":["Journal of Patient-Centered Research and Reviews"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:56:46Z","timestamp":1790963806000},"score":1,"resource":{"primary":{"URL":"https:\/\/institutionalrepository.aah.org\/jpcrr\/vol10\/iss1\/3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,17]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1,17]]}},"URL":"https:\/\/doi.org\/10.17294\/2330-0698.1951","relation":{},"ISSN":["2330-0698"],"issn-type":[{"value":"2330-0698","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,17]]}}}