{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:20:32Z","timestamp":1765610432729,"version":"build-2065373602"},"reference-count":0,"publisher":"Association of Basic Medical Sciences of FBIH","issue":"4","license":[{"start":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:00:00Z","timestamp":1707523200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomol Biomed"],"abstract":"<jats:p>This study explores the correlation between immunological and clinical characteristics in coronavirus disease 2019 (COVID-19) patients with detectable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in feces, analyzing data from 251 patients admitted to Mostar University Clinical Hospital (UCH) from December 2021 to January 2022. Methods involved reverse transcription quantitative polymerase chain reaction (RT-qPCR) from nasopharyngeal (NP) swabs and feces, alongside serological tests for anti-SARS-CoV-2 spike IgGs. Demographic and clinical data were collected through questionnaires and medical records. The data analyses were performed using SPSS statistical software. Death occurred in 53 patients (21.1%, P &lt; 0.001), mostly in the elderly (47\/53, 88.7%, P = 0.001) and immunocompromised (19\/53, 35.8%, P = 0.05), particularly those developing acute respiratory insufficiency (ARI) (46\/53, 86.8%, P = 0.004), and severe\/critical disease (46\/53, 86.8%, P = 0.002). Among the patients with positive anti-SARS-CoV-2 IgG antibodies (86\/251, 34.3%, P &lt; 0.001), 41 (47.7%) were vaccinated and 45 (52.3%) unvaccinated (P = 0.666), showing no significant differences in clinical outcomes or mortality. Unvaccinated patients with a negative antibody titer had a higher incidence of ARI (96\/123, 78%, P = 0.029) and intensive care unit (ICU) admission (22\/123, 17.9%, P = 0.026), than those with a positive antibody titer. Forty-seven (62.7%) patients, out of the 75 hospitalized who provided a feces sample, were positive for SARS-CoV-2 RNA (P = 0.028), without statistical differences between fecal SARS-CoV-2 positive and negative groups regarding vaccination status (15\/47, 31.9%, P = 0.493), antibody status (18\/47, 38.3%, P = 0.628), or death outcome (5\/47, 10.6%, P = 0.706). In conclusion, unvaccinated hospitalized patients with a severe COVID-19 presentation and a negative anti-spike SARS-CoV-2 IgG titer had adverse outcomes more frequently. This suggests cautious consideration for the diagnostic use of fecal samples compared to NP swabs.<\/jats:p>","DOI":"10.17305\/bb.2024.10176","type":"journal-article","created":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T10:03:27Z","timestamp":1707559407000},"page":"1016-1027","source":"Crossref","is-referenced-by-count":1,"title":["Excretion of SARS-CoV-2 RNA in feces has no prognostic benefit in the outcome of COVID-19: A clinical and immunological study"],"prefix":"10.17305","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5401-9001","authenticated-orcid":false,"given":"Bo\u017eo","family":"\u0160u\u0161ak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4827-4789","authenticated-orcid":false,"given":"Monika","family":"Dalmatin-Dragi\u0161i\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4905-3299","authenticated-orcid":false,"given":"Luka","family":"Laura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8913-3018","authenticated-orcid":false,"given":"Vinka","family":"Mikuli\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"Naki\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivanka","family":"Mikuli\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8839-7839","authenticated-orcid":false,"given":"Ilija","family":"Brizi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7674-6795","authenticated-orcid":false,"given":"Jurica","family":"Arapovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6043-3666","authenticated-orcid":false,"given":"Maja","family":"Arapovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6922","published-online":{"date-parts":[[2024,2,10]]},"container-title":["Biomolecules and Biomedicine"],"original-title":[],"link":[{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/10176\/3173","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/10176\/3173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T23:05:27Z","timestamp":1761865527000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/view\/10176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,10]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,7,28]]}},"URL":"https:\/\/doi.org\/10.17305\/bb.2024.10176","relation":{},"ISSN":["2831-090X","2831-0896"],"issn-type":[{"type":"electronic","value":"2831-090X"},{"type":"print","value":"2831-0896"}],"subject":[],"published":{"date-parts":[[2024,2,10]]}}}