{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:12:52Z","timestamp":1787155972394,"version":"build-2736575974"},"reference-count":0,"publisher":"Association of Basic Medical Sciences of FBIH","issue":"11","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomol Biomed"],"abstract":"<jats:p>Serum ferritin, a marker of systemic inflammation and iron metabolism, has been implicated in the outcomes of patients with relapsed\/refractory multiple myeloma (R\/R MM). However, its prognostic significance in R\/R MM patients undergoing chimeric antigen receptor-modified T-cell (CAR-T) therapy remains unclear. This meta-analysis aimed to evaluate the association between pre-infusion serum ferritin levels and survival outcomes in R\/R MM patients treated with CAR-T therapy. We systematically searched PubMed, Embase, and Web of Science for relevant studies. Studies reporting progression-free survival (PFS) and\/or overall survival (OS) based on serum ferritin levels were included. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled using a random-effects model.\u00a0Eight retrospective cohort studies, encompassing 1077 patients, met the inclusion criteria. High pre-infusion serum ferritin levels were significantly associated with worse PFS (HR: 2.15, 95% CI: 1.74\u20132.66, P &lt; 0.001) and OS (HR: 2.86, 95% CI: 2.20\u20133.72, P &lt; 0.001), with mild heterogeneity (I\u00b2 = 9% for PFS and 0% for OS). Sensitivity analyses, conducted by excluding one study at a time, confirmed the robustness of these findings. Subgroup analyses showed consistent results across different CAR-T product sources (commercial vs\u00a0academic), ferritin cutoffs, and follow-up durations (P for subgroup differences all &gt;0.05).\u00a0In conclusion, elevated serum ferritin levels before CAR-T infusion predict poorer survival outcomes in R\/R MM patients. These findings highlight the potential prognostic value of ferritin and its role in optimizing patient selection and management strategies in CAR-T therapy.<\/jats:p>","DOI":"10.17305\/bb.2025.12129","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T19:26:25Z","timestamp":1743189985000},"page":"2416-2427","source":"Crossref","is-referenced-by-count":5,"title":["Serum ferritin as a prognostic biomarker in CAR-T therapy for multiple myeloma: A meta-analysis"],"prefix":"10.17305","volume":"25","author":[{"given":"Jing","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6922","published-online":{"date-parts":[[2025,3,28]]},"container-title":["Biomolecules and Biomedicine"],"original-title":[],"link":[{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/12129\/3843","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/12129\/3843","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T22:01:47Z","timestamp":1761170507000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/view\/12129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,28]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,9,10]]}},"URL":"https:\/\/doi.org\/10.17305\/bb.2025.12129","relation":{},"ISSN":["2831-090X","2831-0896"],"issn-type":[{"value":"2831-090X","type":"electronic"},{"value":"2831-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3,28]]}}}