{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T21:06:36Z","timestamp":1761167196645,"version":"build-2065373602"},"reference-count":0,"publisher":"Association of Basic Medical Sciences of FBIH","issue":"1","license":[{"start":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T00:00:00Z","timestamp":1754179200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomol Biomed"],"abstract":"<jats:p>Intravenous (IV) iron is widely utilized to manage anemia in patients undergoing maintenance hemodialysis; however, its long-term safety remains uncertain. This meta-analysis aimed to evaluate the impact of IV iron on all-cause mortality and major adverse cardiovascular events (MACEs) within this population. We conducted a systematic search of PubMed, Embase, Cochrane Library, Web of Science, Wanfang, and CNKI up to March 2025 for randomized controlled trials (RCTs) that compared IV iron with placebo\/usual care, oral iron, or varying doses of IV iron in adult hemodialysis patients. The primary outcomes assessed were all-cause mortality and MACEs. Data were synthesized using a random-effects model, and the quality of evidence was evaluated employing the GRADE approach. A total of fifteen RCTs involving 4,257 patients were included in the analysis. Compared to placebo\/usual care, IV iron did not significantly affect all-cause mortality (OR: 1.36; 95% CI: 0.60\u20133.09) or MACEs (OR: 0.81; 95% CI: 0.43\u20131.55), with a moderate level of evidence. Furthermore, IV iron demonstrated no significant differences in mortality (OR: 0.58; 95% CI: 0.18\u20131.90) or MACEs (OR: 2.47; 95% CI: 0.37\u201316.34) when compared to oral iron, although the quality of evidence in this comparison was very low. High-dose IV iron was associated with a reduced mortality rate compared to low-dose IV iron (OR: 0.81; 95% CI: 0.67\u20130.97), though this result was influenced by a single large study. In conclusion, IV iron does not appear to increase mortality or MACEs relative to placebo or oral iron. While high-dose IV iron may decrease mortality, the evidence remains limited, indicating a need for further research.<\/jats:p>","DOI":"10.17305\/bb.2025.12652","type":"journal-article","created":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T22:00:34Z","timestamp":1754258434000},"page":"65-78","source":"Crossref","is-referenced-by-count":0,"title":["Influence of intravenous iron therapy on mortality and cardiovascular events of patients on hemodialysis: A meta-analysis"],"prefix":"10.17305","volume":"26","author":[{"given":"Yan","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanxia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Tu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengyun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6922","published-online":{"date-parts":[[2025,8,3]]},"container-title":["Biomolecules and Biomedicine"],"original-title":[],"link":[{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/12652\/3977","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/12652\/3977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T22:04:11Z","timestamp":1761084251000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/view\/12652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,3]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,9,25]]}},"URL":"https:\/\/doi.org\/10.17305\/bb.2025.12652","relation":{},"ISSN":["2831-090X","2831-0896"],"issn-type":[{"type":"electronic","value":"2831-090X"},{"type":"print","value":"2831-0896"}],"subject":[],"published":{"date-parts":[[2025,8,3]]}}}