{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T23:04:02Z","timestamp":1767740642960,"version":"3.48.0"},"reference-count":0,"publisher":"Association of Basic Medical Sciences of FBIH","issue":"5","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomol Biomed"],"abstract":"<jats:p>Masseter muscle spasm after succinylcholine can herald malignant hyperthermia (MH) in genetically susceptible individuals. We aimed to describe the perioperative course and genetic findings in a patient who developed transient masseter spasm and postoperative rhabdomyolysis after general anesthesia. This single-patient case report draws on perioperative observations, laboratory testing, and whole-genome sequencing. Immediately after induction with propofol and succinylcholine, the patient experienced transient masseter spasm; anesthesia was then maintained with total intravenous anesthesia (propofol and remifentanil). Postoperatively, laboratory studies showed severe rhabdomyolysis with mild pigment nephropathy; the patient received intravenous hydration, laboratory values normalized by postoperative day 4, and discharge occurred in good condition. Whole-genome sequencing identified heterozygous ryanodine receptor 1 (RYR1)\u00a0c.1840C&gt;T (p.Arg614Cys)\u2014a known MH-susceptibility variant in the skeletal-muscle ryanodine receptor\u2014and butyrylcholinesterase\u00a0(BCHE)\u00a0c.293A&gt;G (p.Asp98Gly), which reduces butyrylcholinesterase activity and delays succinylcholine hydrolysis. The coexistence of these variants likely synergistically increased sarcoplasmic reticulum Ca\u00b2\u207a release and prolonged succinylcholine effect, precipitating rhabdomyolysis; to our knowledge, this appears to be the first reported case linking concurrent RYR1 and BCHE variants to rhabdomyolysis following general anesthesia.<\/jats:p>","DOI":"10.17305\/bb.2025.13435","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T23:00:36Z","timestamp":1762815636000},"page":"862-868","source":"Crossref","is-referenced-by-count":0,"title":["Succinylcholine-induced rhabdomyolysis in a patient with &lt;i&gt;RYR1\u00a0&lt;\/i&gt;and &lt;i&gt;BCHE&lt;\/i&gt;\u00a0variants: A case report"],"prefix":"10.17305","volume":"26","author":[{"given":"Tracy E.","family":"Harrison","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toby N.","family":"Weingarten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0320-0230","authenticated-orcid":false,"given":"Juraj","family":"Sprung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6922","published-online":{"date-parts":[[2025,11,10]]},"container-title":["Biomolecules and Biomedicine"],"original-title":[],"link":[{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/13435\/4042","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/13435\/4057","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/13435\/4042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T23:01:55Z","timestamp":1767740515000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/view\/13435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,10]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,1,6]]}},"URL":"https:\/\/doi.org\/10.17305\/bb.2025.13435","relation":{},"ISSN":["2831-090X","2831-0896"],"issn-type":[{"type":"electronic","value":"2831-090X"},{"type":"print","value":"2831-0896"}],"subject":[],"published":{"date-parts":[[2025,11,10]]}}}