{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:08:15Z","timestamp":1789682895311,"version":"4.0.1"},"reference-count":0,"publisher":"Association of Basic Medical Sciences of FBIH","issue":"11","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomol Biomed"],"abstract":"<jats:p>Socio-emotional and exploratory behaviors in zebrafish (Danio rerio) are shaped by conserved neuromodulators such as oxytocin (OXT), yet phenotypic variation (e.g., albinism) may modify sensitivity to OXT-dependent regulation. Here, we tested whether pigmentation phenotype alters behavioral responses to acute OXT across structured social and anxiogenic contexts. Adult albino (A; n\u00a0= 30) and non-albino (N; n\u00a0= 30) zebrafish (total n\u00a0= 60; equal allocation across 6 groups, n\u00a0= 10\/group) were exposed to OXT by immersion (33.2 ng\/mL, 15 min) under a 2 \u00d7 3 factorial design (Phenotype \u00d7 Dosing regimen: Vehicle; OXT single exposure assessed at 24 h; OXT repeated exposure assessed at 48 h) and evaluated using the social preference test (SPT), social interaction (SI) test, and novel tank test (NTT). In the SPT, decision-zone occupancy and mean distance to the non-social arm were robustly modulated by dosing (p\u00a0&lt; 0.0001; p\u00a0= 0.007) without phenotype \u00d7 dosing interactions; locomotor outputs (swimming distance, p\u00a0= 0.040; velocity, p\u00a0= 0.041; counterclockwise rotations, p\u00a0= 0.006) also showed dosing effects only, supporting a dissociation between social allocation and global motor output. In the SI test, stimulus-zone occupancy showed a significant main effect of phenotype (p\u00a0= 0.009), independent of dosing, and locomotor indices similarly exhibited phenotype effects without interaction (swimming distance and velocity, p\u00a0= 0.017; mobile-state duration, p\u00a0= 0.002). In contrast, the NTT revealed phenotype-dependent locomotor regulation: highly mobile duration showed a significant interaction (p\u00a0= 0.002) with strong main effects of phenotype and dosing (both p\u00a0&lt; 0.001), while immobile duration displayed an interaction (p\u00a0= 0.015) and dosing effect (p\u00a0= 0.005), driven primarily by the non-albino phenotype; clockwise rotation (p\u00a0= 0.018) and active-state duration (p\u00a0= 0.030) further indicated phenotype-related differences. Collectively, OXT exerts context- and dosing-regimen-dependent modulation in zebrafish, with social allocation primarily dosing-driven and largely phenotype-independent, whereas anxiety-related locomotor dynamics show marked phenotype specificity.<\/jats:p>","DOI":"10.17305\/bb.2026.13819","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T11:47:45Z","timestamp":1775735265000},"page":"2088-2099","source":"Crossref","is-referenced-by-count":0,"title":["Oxytocin modulates social preference and anxiety-like locomotor behavior in albino and non-albino zebrafish"],"prefix":"10.17305","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8603-3797","authenticated-orcid":false,"given":"Ana Maria","family":"Danila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2030-1436","authenticated-orcid":false,"given":"Alexandra","family":"Savuca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9755-6771","authenticated-orcid":false,"given":"Mircea-Nicusor","family":"Nicoara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alin Stelian","family":"Ciobica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4501-1718","authenticated-orcid":false,"given":"Bogdan","family":"Novac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Chiriac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4023-1765","authenticated-orcid":false,"given":"Ovidiu-Dumitru","family":"Ilie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6922","published-online":{"date-parts":[[2026,4,9]]},"container-title":["Biomolecules and Biomedicine"],"original-title":[],"link":[{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/13819\/4166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/13819\/4166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:01:00Z","timestamp":1789682460000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/view\/13819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,9]]},"references-count":0,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,9,16]]}},"URL":"https:\/\/doi.org\/10.17305\/bb.2026.13819","relation":{},"ISSN":["2831-090X","2831-0896"],"issn-type":[{"value":"2831-090X","type":"electronic"},{"value":"2831-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4,9]]}}}