{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T22:13:47Z","timestamp":1778105627429,"version":"3.51.4"},"reference-count":0,"publisher":"Association of Basic Medical Sciences of FBIH","issue":"9","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomol Biomed"],"abstract":"<jats:p>Elderly bronchial asthma is a heterogeneous, often non-atopic disorder characterized by airway inflammation and remodeling influenced by age-related immune dysregulation. This review aims to elucidate the roles of helper T cells (Th cells) and chemokine networks in driving elderly asthma and to emphasize implications for precise diagnosis and targeted therapy. We performed a narrative synthesis of studies from PubMed and Web of Science (January 2020\u2013December 2025) utilizing the keywords \"elderly asthma,\" \"helper T cells,\" \"chemokines,\" \"airway inflammation,\" and \"immunosenescence,\" focusing on human cohorts aged \u226565 years and aged animal models. The literature reveals that the pathogenesis of elderly asthma is characterized by an imbalance between T helper 1 (Th1) and T helper 2 (Th2) responses, enhanced T helper 17 (Th17) activity, and diminished regulatory T cell (Treg) function, changes that are exacerbated by immunosenescence. Key chemokine axes\u2014including C-C motif chemokine ligand 11 (CCL11)\/C-C chemokine receptor 3 (CCR3), C-X-C motif chemokine ligand 8 (CXCL8)\/C-X-C chemokine receptor 1 (CXCR1) and C-X-C chemokine receptor 2 (CXCR2), C-C motif chemokine ligand 2 (CCL2)\/C-C chemokine receptor 2 (CCR2), C-X3-C motif chemokine ligand 1 (CX3CL1)\/C-X3-C chemokine receptor 1 (CX3CR1), and stromal cell-derived factor 1 (SDF-1)\/C-X-C motif chemokine ligand 12 (CXCL12)\/C-X-C chemokine receptor 4 (CXCR4)\u2014facilitate the recruitment of eosinophils, neutrophils, and monocytes\/macrophages, thereby sustaining airway inflammation and remodeling. Overall, Th-chemokine circuits represent actionable targets for biomarker-guided, personalized treatment; however, further mechanistic and clinical validation studies specific to the elderly population are crucial for effective translation into practice.<\/jats:p>","DOI":"10.17305\/bb.2026.13875","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T09:00:21Z","timestamp":1773133221000},"page":"1476-1485","source":"Crossref","is-referenced-by-count":0,"title":["Helper T cells and chemokines in elderly asthma \u2013 Mechanisms of airway inflammation and remodeling: A review"],"prefix":"10.17305","volume":"26","author":[{"given":"Youhua","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6922","published-online":{"date-parts":[[2026,3,10]]},"container-title":["Biomolecules and Biomedicine"],"original-title":[],"link":[{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/13875\/4151","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/13875\/4151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T22:02:13Z","timestamp":1778104933000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/view\/13875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,10]]},"references-count":0,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,5,5]]}},"URL":"https:\/\/doi.org\/10.17305\/bb.2026.13875","relation":{},"ISSN":["2831-090X","2831-0896"],"issn-type":[{"value":"2831-090X","type":"electronic"},{"value":"2831-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,10]]}}}