{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:45:14Z","timestamp":1785797114212,"version":"3.56.0"},"reference-count":0,"publisher":"Association of Basic Medical Sciences of FBIH","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomol Biomed"],"abstract":"<jats:p>Breast cancer-related lymphedema (BCRL) is a prevalent and debilitating complication following breast cancer surgery. Progressive resistance exercise (PRE) has been proposed as a preventive strategy, yet evidence from randomized controlled trials (RCTs) remains inconclusive. This meta-analysis aimed to evaluate the impact of PRE on the incidence of postoperative BCRL. We conducted a comprehensive search of PubMed, Cochrane Library, Embase, and Web of Science for RCTs comparing PRE with non-PRE interventions in adults undergoing breast cancer surgery without baseline lymphedema. Risk ratios (RRs) with 95% confidence intervals (CIs) were aggregated using a random-effects model to address potential heterogeneity. A total of eleven RCTs involving 1,450 women were included in the analysis. The findings indicated that PRE significantly reduced the risk of BCRL compared to control groups (RR = 0.68, 95% CI: 0.53\u20130.88; p\u00a0= 0.003), with no significant heterogeneity observed (I\u00b2 = 0%). The results were consistent in leave-one-out sensitivity analyses and remained robust after excluding two high-risk studies (RR = 0.65, 95% CI: 0.49\u20130.85). Furthermore, subgroup analyses revealed no significant modifications in results based on age, baseline body mass index, axillary lymph node dissection status, timing of PRE initiation, intervention duration, follow-up length, or diagnostic criteria (all p\u00a0for subgroup difference &gt; 0.05). Egger's test showed no significant risk of publication bias (p\u00a0= 0.68). The certainty of evidence was rated as moderate, primarily downgraded due to the risk of bias associated with the open-label design of the included RCTs. In conclusion, PRE may be linked to a reduced incidence of BCRL following breast cancer surgery, supported by moderate-certainty evidence. Therefore, PRE should be considered as a component of postoperative rehabilitation and a potential strategy for lymphedema prevention, although further high-quality studies are necessary to validate these findings.<\/jats:p>","DOI":"10.17305\/bb.2026.14006","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T11:50:34Z","timestamp":1782474634000},"source":"Crossref","is-referenced-by-count":0,"title":["Progressive resistance exercise for preventing breast cancer-related lymphedema after breast cancer surgery: A systematic review and meta-analysis"],"prefix":"10.17305","author":[{"given":"Shufang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6922","published-online":{"date-parts":[[2026,6,26]]},"container-title":["Biomolecules and Biomedicine"],"original-title":[],"link":[{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/14006\/4236","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/14006\/4236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:00:55Z","timestamp":1785794455000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/view\/14006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,26]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17305\/bb.2026.14006","relation":{},"ISSN":["2831-090X","2831-0896"],"issn-type":[{"value":"2831-090X","type":"electronic"},{"value":"2831-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,26]]}}}