{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:58:24Z","timestamp":1785365904845,"version":"3.55.0"},"reference-count":0,"publisher":"Association of Basic Medical Sciences of FBIH","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomol Biomed"],"abstract":"<jats:p>Acute pancreatitis (AP) has a highly variable clinical course, making early identification of patients at risk of severe acute pancreatitis (SAP) essential for timely management. This study evaluated the ability of the C-reactive protein-to-albumin ratio (CRP\/albumin ratio) at hospital admission to predict SAP and compared its performance with established prognostic scoring systems. This retrospective, single-center cohort study included 502 adults admitted with AP between January 2024 and December 2025. Disease severity was classified according to the revised Atlanta classification. The CRP\/albumin ratio was calculated at admission and during serial follow-up, and its predictive performance was assessed using receiver operating characteristic (ROC) curve analysis and Firth logistic regression. Overall, 308 patients (61.4%) had mild, 130 (25.9%) had moderately severe, and 64 (12.7%) had severe AP. The admission CRP\/albumin ratio was significantly higher in patients with SAP than in those with less severe disease (p&lt;0.001), and the difference persisted during follow-up. The ratio demonstrated acceptable discrimination for SAP, with an area under the curve (AUC) of 0.796 (95% confidence interval [CI]: 0.666\u20130.925). A cut-off value of 24.89 provided 69.6% sensitivity and 86.0% specificity. Its discriminatory performance was comparable to that of the Acute Physiology and Chronic Health Evaluation II (APACHE II) score (AUC: 0.800; p=0.959). In complete-case multivariable Firth logistic regression involving 66 patients, including 23 with SAP, the CRP\/albumin ratio remained independently associated with SAP (odds ratio: 1.035; 95% CI: 1.011\u20131.072; p&lt;0.001). The admission CRP\/albumin ratio may therefore serve as a simple and readily available complementary marker for early risk stratification in AP, although the proposed cut-off requires validation in prospective multicenter studies.<\/jats:p>","DOI":"10.17305\/bb.2026.14587","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T07:53:34Z","timestamp":1784879614000},"source":"Crossref","is-referenced-by-count":0,"title":["Prognostic value of the C-reactive protein-to-albumin ratio in acute pancreatitis"],"prefix":"10.17305","author":[{"given":"Ali","family":"Avci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9193-4105","authenticated-orcid":false,"given":"Zeynep","family":"Gok Sargin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Sargin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esved Melih","family":"Acikgoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7967-6171","authenticated-orcid":false,"given":"Celal","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3614-2751","authenticated-orcid":false,"given":"Ahmet","family":"Caliskan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yavuz Fatih","family":"Yavuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6922","published-online":{"date-parts":[[2026,7,24]]},"container-title":["Biomolecules and Biomedicine"],"original-title":[],"link":[{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/14587\/4264","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/14587\/4264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:00:37Z","timestamp":1785362437000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/view\/14587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17305\/bb.2026.14587","relation":{},"ISSN":["2831-090X","2831-0896"],"issn-type":[{"value":"2831-090X","type":"electronic"},{"value":"2831-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,24]]}}}