{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:49:13Z","timestamp":1791586153942,"version":"4.3.4"},"reference-count":0,"publisher":"Association of Basic Medical Sciences of FBIH","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomol Biomed"],"abstract":"<jats:p>Accurate assessment of breast cancer response to neoadjuvant chemotherapy (NAC) is important for surgical planning. We compared contrast-enhanced mammography (CEM), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), and fluorine-18 fluorodeoxyglucose positron emission tomography\/computed tomography (\u00b9\u2078F-FDG PET\/CT) for predicting breast pathologic complete response (pCR) and assessing residual disease. This retrospective single-center study included 76 patients who underwent all three modalities before and after NAC, followed by surgery. Postoperative histopathology was the reference standard; breast pCR was defined as the absence of residual invasive carcinoma in the breast, irrespective of residual ductal carcinoma in situ. Breast pCR occurred in 28 patients (36.8%). CEM had higher sensitivity than DCE-MRI (89.3% versus 60.7%; p\u00a0= 0.012) and the highest negative predictive value (92.1%), whereas DCE-MRI had the highest specificity (85.4%) and positive predictive value (70.8%). Accuracy was 79.0%, 76.3%, and 73.7% for CEM, DCE-MRI, and \u00b9\u2078F-FDG PET\/CT, respectively, without a significant difference among modalities (p\u00a0= 0.661). Corresponding areas under the receiver operating characteristic curve were 0.841, 0.844, and 0.769. Among 48 patients with residual invasive disease, intraclass correlation coefficients for CEM and DCE-MRI measurements versus pathology were 0.733 and 0.773, respectively. However, 95% limits of agreement were wide (\u221234.16 to 25.16 mm and \u221229.26 to 20.93 mm, respectively), indicating substantial individual-level discrepancies. CEM showed promise for post-NAC breast response assessment in this selected cohort, but the findings do not establish equivalence or interchangeability with DCE-MRI. Individual tumor size estimates require caution, and prospective multicenter validation is warranted.<\/jats:p>","DOI":"10.17305\/bb.2026.14598","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T08:51:53Z","timestamp":1790585513000},"source":"Crossref","is-referenced-by-count":0,"title":["Pathologic complete response and residual disease after neoadjuvant chemotherapy in breast cancer: Comparison of contrast-enhanced mammography, DCE-MRI, and \u00b9\u2078F-FDG PET\/CT"],"prefix":"10.17305","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7130-0121","authenticated-orcid":false,"given":"Ebru","family":"Ozan Sanhal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3427-2023","authenticated-orcid":false,"given":"\u0130mren","family":"Mutlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8318-0785","authenticated-orcid":false,"given":"Evrim","family":"S\u00fcrer Budak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veli","family":"Vural","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130smail","family":"Zihni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00fcbra","family":"Sim\u015fek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sema","family":"Sezgin G\u00f6ksu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cumhur","family":"Ar\u0131c\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6922","published-online":{"date-parts":[[2026,9,28]]},"container-title":["Biomolecules and Biomedicine"],"original-title":[],"link":[{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/14598\/4338","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/14598\/4338","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:00:40Z","timestamp":1791583240000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/view\/14598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17305\/bb.2026.14598","relation":{},"ISSN":["2831-090X","2831-0896"],"issn-type":[{"value":"2831-090X","type":"electronic"},{"value":"2831-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,28]]}}}