{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:50:32Z","timestamp":1791327032480,"version":"4.3.1"},"reference-count":0,"publisher":"Association of Basic Medical Sciences of FBIH","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomol Biomed"],"abstract":"<jats:p>Cholangiocarcinoma (CCA) has a poor prognosis, highlighting the need for clinically informative biomarkers. This retrospective study examined associations of major histocompatibility complex class I chain-related molecules A (MICA) and B (MICB) and serum soluble MICA (sMICA) with clinical characteristics and survival. Transcript levels, combined tissue MICA and MICB (MICA\/B) protein expression, and serum sMICA were assessed using real-time reverse transcription polymerase chain reaction, immunohistochemistry, and enzyme-linked immunosorbent assay in partially overlapping cohorts of 30, 101, and 118 patients, respectively; serum from 10 controls was also analyzed. Survival associations were evaluated using Kaplan\u2013Meier and Cox regression analyses. MICA\u00a0transcript levels were elevated in tumors compared with paired adjacent normal tissues (p\u00a0= 0.006), whereas MICB\u00a0transcripts were detected in 7\/30 tumors. High tissue MICA\/B expression was associated with longer median overall survival (40.70 versus 16.36 months; p\u00a0= 0.008) and lower mortality after multivariable adjustment (hazard ratio, 0.47; 95% confidence interval, 0.25\u20130.89; p\u00a0= 0.020). Serum sMICA was elevated in advanced CCA. Exploratory analyses yielded areas under the receiver operating characteristic curve of 0.689 for advanced versus non-advanced CCA and 0.770 for advanced CCA versus controls. At an exploratory upper-quartile threshold (&gt;1466.62 pg\/mL), high sMICA was associated with shorter survival (p\u00a0= 0.014), but the adjusted association was not statistically significant (hazard ratio, 1.89; 95% confidence interval, 0.93\u20133.84; p\u00a0= 0.081). Tissue MICA\/B expression may have prognostic relevance, whereas serum sMICA may reflect advanced disease; independent prospective validation is required.<\/jats:p>","DOI":"10.17305\/bb.2026.14764","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T08:06:45Z","timestamp":1789373205000},"source":"Crossref","is-referenced-by-count":0,"title":["Tissue MICA\/B expression and serum soluble MICA in cholangiocarcinoma: Associations with survival and advanced disease"],"prefix":"10.17305","author":[{"given":"Pornsinee","family":"Wilaikaew","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5985-6004","authenticated-orcid":false,"given":"Songpol","family":"Haohan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6163-3740","authenticated-orcid":false,"given":"Malinee","family":"Thanee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8494-4142","authenticated-orcid":false,"given":"Molin","family":"Wongwattanakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2923-1288","authenticated-orcid":false,"given":"Supakan","family":"Amontailak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3190-1472","authenticated-orcid":false,"given":"Sutthiwan","family":"Janthamala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attapol","family":"Titapun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4230-5641","authenticated-orcid":false,"given":"Anchalee","family":"Techasen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6922","published-online":{"date-parts":[[2026,9,14]]},"container-title":["Biomolecules and Biomedicine"],"original-title":[],"link":[{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/14764\/4330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/14764\/4330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:00:41Z","timestamp":1791324041000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/view\/14764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,14]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17305\/bb.2026.14764","relation":{},"ISSN":["2831-090X","2831-0896"],"issn-type":[{"value":"2831-090X","type":"electronic"},{"value":"2831-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,14]]}}}