{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T01:30:26Z","timestamp":1649122226774},"reference-count":0,"publisher":"Association of Basic Medical Sciences of FBIH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bosn J of Basic Med Sci"],"abstract":"<jats:p>Angiotensin\u00a0converting\u00a0enzyme\u00a0(ACE) plays an important role in\u00a0blood\u00a0pressure\u00a0regulation not only in the state of rest, but also during physical\u00a0exercise. The aim of this study was to estimate the\u00a0serum\u00a0ACE\u00a0activity\u00a0in\u00a0response\u00a0to\u00a0acute\u00a0dynamic\u00a0exercise. The study involved a group of young, healthy, male volunteers (average 22 years of age).\u00a0Exercise\u00a0testing was carried out on ergometer bicycle according to the protocol of individually adjusted continuous, constant workload (3 W\/kg). The\u00a0activity\u00a0of ACE in\u00a0serum\u00a0was measured in venous\u00a0blood, in the period of rest, in 4th, 8th and 12th minute of\u00a0exercise\u00a0and 1st, 3rd and 6th minute of recovery by spectrophotometric method. Marked inter-individual differences in basal\u00a0serum\u00a0ACE\u00a0activity\u00a0were determined (range 8, 31-63, 72 U\/L).\u00a0Serum\u00a0ACE\u00a0activity\u00a0did not significantly vary during\u00a0exercise\u00a0and in the period of recovery. Systolic\u00a0blood\u00a0pressure\u00a0changed during\u00a0exercise\u00a0compared to values during rest period in accordance with the applied type of dynamical\u00a0exercise. Diastolic\u00a0blood\u00a0pressure\u00a0did not vary considerably during\u00a0exercise. Statistically significant correlation between mean arterial\u00a0blood\u00a0pressure\u00a0and ACE\u00a0activity\u00a0in the\u00a0serum\u00a0was not found. The lack of increase of ACE\u00a0activity\u00a0in the\u00a0serum, in spite of changes in\u00a0blood\u00a0pressure\u00a0values, most likely shows the presence of alternative ACE independent pathway involved in the production of vasoactive substances that have important role in the regulation of cardiovascular system\u00a0response\u00a0to\u00a0acutedynamic\u00a0exercise.<\/jats:p>","DOI":"10.17305\/bjbms.2004.3357","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T23:14:23Z","timestamp":1527722063000},"page":"32-36","source":"Crossref","is-referenced-by-count":2,"title":["Serum activity of Angiotensin converting enzyme and blood pressure response to acute dynamic exercise"],"prefix":"10.17305","volume":"4","author":[{"given":"Emina","family":"Naka\u0107-I\u0107indi\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Had\u017eimuratovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasminko","family":"Huski\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almira","family":"Had\u017eovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asija","family":"Za\u010diragi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ne\u0161ina","family":"Avdagi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6922","published-online":{"date-parts":[[2004,11,20]]},"container-title":["Bosnian Journal of Basic Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/3357\/964","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/3357\/964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T20:26:58Z","timestamp":1578342418000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bjbms.org\/ojs\/index.php\/bjbms\/article\/view\/3357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,20]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,4,21]]}},"URL":"https:\/\/doi.org\/10.17305\/bjbms.2004.3357","relation":{},"ISSN":["1840-4812","1512-8601"],"issn-type":[{"value":"1840-4812","type":"electronic"},{"value":"1512-8601","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11,20]]}}}