{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:28:47Z","timestamp":1762522127671},"reference-count":0,"publisher":"Association of Basic Medical Sciences of FBIH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bosn J of Basic Med Sci"],"abstract":"<jats:p>The aim of the study was to ascertain the existence of\u00a0intestinal\u00a0metaplasia\u00a0in\u00a0gastric\u00a0mucosa of patients with\u00a0gastric\u00a0carcinoma\u00a0coupled with H.\u00a0pylori\u00a0positive\u00a0chronic\u00a0atrophic\u00a0gastritis\u00a0and possible connection of IM with the development of\u00a0gastric\u00a0carcinoma. The paper presents prospective study that included 50 patients with\u00a0gastric\u00a0carcinoma\u00a0and 50 patients with\u00a0chronic\u00a0atrophic\u00a0H.\u00a0pylori\u00a0positive\u00a0gastritis. All the patients were subjected to gastroscopy as well as biopsy targeted at antrum, lesser curvature and corpus and at the area 1-2 cm removed from tumor lesion. Biopsy samples were sliced by microtome and stained. We analyzed presence, frequency and severity of inflammatory-regenerative, metaplastic and dysplastic changes in the mucosa and evaluated their prognostic value. We typed IM immunohistochemically. This study confirmed responsibility of H.\u00a0pylori\u00a0for inflammatory\u00a0events\u00a0in\u00a0gastric\u00a0mucosa in patients with\u00a0gastriccarcinoma. According to our findings\u00a0incomplete\u00a0IM of types IIa and IIb as precancerous lesion is responsible for the development of\u00a0gastriccarcinoma\u00a0and is associated with\u00a0chronic\u00a0atrophic\u00a0gastritis\u00a0grade I and II (92% of subjects, p=0.0097, h=1, p=0.01). Thus, the finding of\u00a0incomplete\u00a0intestinal\u00a0metaplasia\u00a0may be used as an\u00a0indicator\u00a0for\u00a0early\u00a0gastric\u00a0carcinoma\u00a0detection. Patients with patho-histologically verified\u00a0incomplete\u00a0intestinal\u00a0metaplasia\u00a0associated with active\u00a0chronic\u00a0atrophic\u00a0gastritis\u00a0of levels I and II represent risk group for the development of\u00a0gastric\u00a0carcinoma\u00a0of\u00a0intestinal\u00a0type.<\/jats:p>","DOI":"10.17305\/bjbms.2006.3120","type":"journal-article","created":{"date-parts":[[2018,2,4]],"date-time":"2018-02-04T11:56:46Z","timestamp":1517745406000},"page":"48-53","source":"Crossref","is-referenced-by-count":5,"title":["Incomplete Intestinal Metaplasia as an Indicator for Early Detection of Gastric Carcinoma in The Events of Helicobacter Pylori Positive Chronic Atrophic Gastritis"],"prefix":"10.17305","volume":"6","author":[{"given":"Zora","family":"Vukobrat-Bijedi\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svjetlana","family":"Radovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azra","family":"Husi\u0107-Selimovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sr\u0111an","family":"Gornjakovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6922","published-online":{"date-parts":[[2006,11,20]]},"container-title":["Bosnian Journal of Basic Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/3120\/838","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/3120\/838","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T20:33:56Z","timestamp":1578342836000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bjbms.org\/ojs\/index.php\/bjbms\/article\/view\/3120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,20]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2008,11,20]]}},"URL":"https:\/\/doi.org\/10.17305\/bjbms.2006.3120","relation":{},"ISSN":["1840-4812","1512-8601"],"issn-type":[{"value":"1840-4812","type":"electronic"},{"value":"1512-8601","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11,20]]}}}