{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T06:30:24Z","timestamp":1649053824878},"reference-count":0,"publisher":"Association of Basic Medical Sciences of FBIH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bosn J of Basic Med Sci"],"abstract":"<jats:p>Down Syndrome\u00a0(DS) or trisomy 21 (T21) is the most frequent and the best known malformation\u00a0syndrome\u00a0associated with mental deficiency that appears in human,. Average incidence of this\u00a0syndrome\u00a0is about 1:700 newborns. Numerous researchers noted\u00a0thyroid\u00a0disorders in people with\u00a0Down Syndrome\u00a0but, clinical symptoms of\u00a0thyroid\u00a0dysfunction are difficult to separate from DS phenotype. The aim of this study was to examine the\u00a0thyroid\u00a0function in the patients with DS. Our results confirmed higher frequency of\u00a0thyroid\u00a0dysfunction in DS patients. Higher values of TSH were found in 60,34% of the examined DS patients, which is significantly higher value comparing with the control group (p&lt;0,01). Compensated hypothyroidism was established in 27,92% of the examined DS patients, and most of those (63,23%) were younger than 6 years. The conclusions emphasize the necessity of implementation of\u00a0thyroid\u00a0function screening program in persons with DS, and the need for adequate treatment of its dysfunction. Thus, the symptoms of the disease would be alleviated and better physical and mental fitness ensured.<\/jats:p>","DOI":"10.17305\/bjbms.2006.3142","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T19:17:01Z","timestamp":1527707821000},"page":"38-42","source":"Crossref","is-referenced-by-count":6,"title":["Down Syndrome and Thyroid Gland"],"prefix":"10.17305","volume":"6","author":[{"given":"Mensuda","family":"Hasanhod\u017ei\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Husref","family":"Tahirovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ljerka","family":"Lukinac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6922","published-online":{"date-parts":[[2006,8,20]]},"container-title":["Bosnian Journal of Basic Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/3142\/852","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/3142\/852","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T15:34:09Z","timestamp":1578324849000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bjbms.org\/ojs\/index.php\/bjbms\/article\/view\/3142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,20]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,2,8]]}},"URL":"https:\/\/doi.org\/10.17305\/bjbms.2006.3142","relation":{},"ISSN":["1840-4812","1512-8601"],"issn-type":[{"value":"1840-4812","type":"electronic"},{"value":"1512-8601","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8,20]]}}}