{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T23:00:27Z","timestamp":1784934027076,"version":"3.55.0"},"reference-count":0,"publisher":"Association of Basic Medical Sciences of FBIH","issue":"3","license":[{"start":{"date-parts":[[2006,8,20]],"date-time":"2006-08-20T00:00:00Z","timestamp":1156032000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomol Biomed"],"abstract":"<jats:p>The aim of the study was to ascertain presence of\u00a0Helicobacter\u00a0pylori\u00a0in\u00a0gastric\u00a0carcinoma as a responsible\u00a0promoter\u00a0of inflammatory-regenerative changes, which lead to\u00a0pathological\u00a0differentiation\u00a0and\u00a0transformation\u00a0of\u00a0normal\u00a0epithelial cells into intestinal\u00a0type\u00a0and, in progression, cause epithelial dysplasia that develops into early\u00a0gastric\u00a0carcinoma. The paper presents prospective study that includes clinical, pathohistological and microbiological aspects of carcinogenesis initiation in\u00a0gastric\u00a0mucosa. The subjects are patients treated at Gastroenterohepatology Clinic divided into two groups. One group included 50 patients with\u00a0gastric\u00a0carcinoma while the control group included 50 patients with chronic atrophic H.\u00a0pylori\u00a0positive gastritis. All the patients were subjected to endoscopy as well as biopsy targeted at antrum, lesser curvature and corpus and at the region 1-2 cm removed from tumor lesion. We used HUT test to verify H.\u00a0pylori\u00a0presence in biopsy samples. We analyzed the samples for presence, frequency and severity of inflammatory-regenerative, metaplastic and dysplastic changes in\u00a0gastric\u00a0mucosa\u00a0and evaluated their meaning for the prognosis. Our study confirmed Helicobaster\u00a0pylori\u00a0responsibility for inflammatory events in\u00a0gastric\u00a0mucosa\u00a0in patients with\u00a0gastric\u00a0carcinoma. Slight and mild epithelial dysplasia with chronic atrophic gastritis grade I and II coupled with intestinal metaplasia may be considered an indicator for early detection of carcinoma. Such patients represent risk group for\u00a0gastric\u00a0carcinoma development.<\/jats:p>","DOI":"10.17305\/bjbms.2006.3146","type":"journal-article","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T19:17:01Z","timestamp":1527707821000},"page":"57-60","source":"Crossref","is-referenced-by-count":0,"title":["Helicobacter Pylori as a Promoter of Accelerated Regeneration, Pathological Differentiation and Transformation of Normal Gastric Mucosa into Cancerous Type"],"prefix":"10.17305","volume":"6","author":[{"given":"Zora","family":"Vukobrat-Bijedi\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svjetlana","family":"Radovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azra","family":"Husi\u0107-Selimovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sr\u0111an","family":"Gornjakovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6922","published-online":{"date-parts":[[2006,8,20]]},"container-title":["Biomolecules and Biomedicine"],"original-title":[],"link":[{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/3146\/856","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/3146\/856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T22:01:08Z","timestamp":1784930468000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/view\/3146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,20]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,2,8]]}},"URL":"https:\/\/doi.org\/10.17305\/bjbms.2006.3146","relation":{},"ISSN":["2831-090X","2831-0896"],"issn-type":[{"value":"2831-090X","type":"electronic"},{"value":"2831-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8,20]]}}}