{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:18:38Z","timestamp":1788232718190,"version":"build-2803163510"},"reference-count":0,"publisher":"Association of Basic Medical Sciences of FBIH","issue":"2","license":[{"start":{"date-parts":[[2014,5,20]],"date-time":"2014-05-20T00:00:00Z","timestamp":1400544000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomol Biomed"],"abstract":"<jats:p>Between their broad spectrum of action,\u00a0vanadium\u00a0compounds are shown to have insulin mimetic\/enhancing effects. Increasing evidence in experimental and clinical studies suggests that\u00a0oxidative\u00a0stress\u00a0plays a major role in the pathogenesis of diabetes and on the onset of\u00a0diabetic\u00a0complications. Thus, preventive therapy can alleviate the possible side effects of the disease. The aim of the present study was to investigate the\u00a0effect\u00a0of vanadyl sulfate supplementation on the antioxidant system in the\u00a0stomach\u00a0tissue\u00a0of\u00a0diabetic\u00a0rats. Male Swiss albino\u00a0rats\u00a0were randomly divided into 4 groups: control; control+vanadyl sulfate;\u00a0diabetic;\u00a0diabetic+vanadyl sulfate. Diabetes was induced by intraperitoneal injection of streptozotocin (STZ; 65 mg\/kg body weight). Vanadyl sulfate (100 mg\/kg body weight) was given daily by gavage for 60 days. At the last day of the experiment,\u00a0stomach\u00a0tissues were taken and homogenized to make a 10% (w\/v) homogenate. Catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GR), glutathione peroxidase (GPx), glutathione-S-transferase (GST), myeloperoxidase (MPO), carbonic anhydrase (CA), glucose-6-phosphate dehydrogenase (G6PD) and lactate dehydrogenase (LDH) activities were determined in the\u00a0stomach\u00a0tissue. CAT, SOD, GR, GPx, GST, CA, G6PD and LDH activities were increased in\u00a0diabetic\u00a0rats\u00a0when compared to normal\u00a0rats.\u00a0Vanadium\u00a0treatment significantly reduced the elevated activities of GR, GPx, GST compared with the\u00a0diabetic\u00a0group whereas the decreases in CAT, SOD, CA, G6PD and LDH activities were insignificant. No significant change was seen for MPO activity between the groups. It was concluded that\u00a0vanadium\u00a0could be used for its\u00a0ameliorative\u00a0effect\u00a0against\u00a0oxidative\u00a0stress\u00a0in diabetes.<\/jats:p>","DOI":"10.17305\/bjbms.2014.2273","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T13:59:13Z","timestamp":1499954353000},"page":"105-109","source":"Crossref","is-referenced-by-count":20,"title":["Ameliorative effect of vanadium on oxidative stress in stomach tissue of diabetic rats"],"prefix":"10.17305","volume":"14","author":[{"given":"Tugba","family":"Yilmaz-Ozden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Kurt-Sirin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevim","family":"Tunali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuriye","family":"Akev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse","family":"Can","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Refiye","family":"Yanardag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6922","published-online":{"date-parts":[[2014,5,20]]},"container-title":["Biomolecules and Biomedicine"],"original-title":[],"link":[{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/2273\/339","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/2273\/339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T23:03:58Z","timestamp":1761951838000},"score":1,"resource":{"primary":{"URL":"https:\/\/bjbms.org\/ojs\/index.php\/bjbms\/article\/view\/2273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,20]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,5,20]]}},"URL":"https:\/\/doi.org\/10.17305\/bjbms.2014.2273","relation":{},"ISSN":["2831-090X","2831-0896"],"issn-type":[{"value":"2831-090X","type":"electronic"},{"value":"2831-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5,20]]}}}