{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:10:43Z","timestamp":1770336643825,"version":"3.49.0"},"reference-count":0,"publisher":"Association of Basic Medical Sciences of FBIH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bosn J of Basic Med Sci"],"abstract":"<jats:p>Uterine leiomyoma (UL) is an estrogen-dependent neoplasm of the uterus, and estrogen metabolizing enzymes affect its progression. This study aimed to evaluate the association between two single-nucleotide polymorphisms of cytochrome P450 1A1 (CYP1A1) gene and UL risk. The study consisted of 105 patients with UL and 112 healthy women as controls. Ile462Val (A\/G) and Asp449Asp (T\/C) polymorphisms of CYP1A1 gene were analyzed by DNA sequencing and polymerase chain reaction-restriction fragment length polymorphism methods, respectively. The findings indicated no association between Ile462Val (A\/G) and Asp449Asp (T\/C) polymorphisms of CYP1A1 gene and UL (p &lt; 0.05). However, the combination effect of TT\/AG genotypes of the Asp449Asp (T\/C) and Ile462Val (A\/G) polymorphisms was associated with 4.3-fold higher risk of UL. In addition, haplotype analysis revealed that TG haplotype of the Asp449Asp (T\/C) and Ile462Val (A\/G) polymorphisms could increase the UL risk nearly 4.9-fold. Asp449Asp (T\/C) and Ile462Val (A\/G) polymorphisms of CYP1A1 gene were not associated with UL susceptibility; however, the combination of the TT\/AG genotypes and TG haplotype could increase the UL risk.<\/jats:p>","DOI":"10.17305\/bjbms.2016.1245","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T21:17:44Z","timestamp":1466630264000},"page":"209-214","source":"Crossref","is-referenced-by-count":6,"title":["Combination effect of cytochrome P450 1A1 gene polymorphisms on uterine leiomyoma: A case-control study"],"prefix":"10.17305","volume":"16","author":[{"given":"Saeedeh","family":"Salimi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mojtaba","family":"Sajadian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Khodamian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atefeh","family":"Yazdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soodabeh","family":"Rezaee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Mohammadpour-Gharehbagh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mojgan","family":"Mokhtari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoo","family":"Yaghmaie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6922","published-online":{"date-parts":[[2016,8,2]]},"container-title":["Bosnian Journal of Basic Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/1245\/270","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/1245\/270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T22:12:37Z","timestamp":1613599957000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bjbms.org\/ojs\/index.php\/bjbms\/article\/view\/1245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,2]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,8,2]]}},"URL":"https:\/\/doi.org\/10.17305\/bjbms.2016.1245","relation":{},"ISSN":["1840-4812","1512-8601"],"issn-type":[{"value":"1840-4812","type":"electronic"},{"value":"1512-8601","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8,2]]}}}