{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:28:20Z","timestamp":1747200500401,"version":"3.40.5"},"reference-count":0,"publisher":"Association of Basic Medical Sciences of FBIH","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bosn J of Basic Med Sci"],"abstract":"<jats:p>The identification of mutually exclusive somatic mutations shared among myeloproliferative neoplasm (MPN) subtypes\u00a0has provided a powerful tool for studying disease evolution. Clinical features, gene mutations, and survival over 18 years were analyzed in MPN patients. One hundred thirty-eight MPN patients were subcategorized according to MPN subtypes: essential thrombocythemia (ET, n = 41), polycythemia vera (PV, n = 56), primary myelofibrosis (PMF, n = 10), and MPN unclassified (MPN-U, n = 31). Patient characteristics included clinical parameters, overall survival, and mutational status of the JAK2, CALR, and MPL genes. We compared hematologic and clinical features of JAK2V617F-ET vs.\u00a0CALR-mutated ET vs. JAK2V617F-PV patients. JAK2V617F-patients had higher values of erythrocytes, hemoglobin, and hematocrit compared to CALR-mutated patients (p &lt; 0.05). The mutant allele burden in JAK2V617F-PV and JAK2V617F-ET patients directly correlated with erythrocyte, hemoglobin, and hematocrit values, but it inversely correlated with platelet count. Thus, mutant allele burden was an indicator of the clinical phenotype in JAK2V617F-MPN patients. OS was not affected by the mutational status. In general, mutated JAK2, CALR, and MPL genes left specific hematological signatures.<\/jats:p>","DOI":"10.17305\/bjbms.2019.4391","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T10:43:56Z","timestamp":1572432236000},"source":"Crossref","is-referenced-by-count":0,"title":["The effects of mutational profiles on phenotypic presentation of myeloproliferative neoplasm subtypes in Bosnia: 18 year follow-up"],"prefix":"10.17305","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6063-7260","authenticated-orcid":false,"given":"Amina","family":"Kurtovic-Kozaric","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1785-5035","authenticated-orcid":false,"given":"Erna","family":"Islamagic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"Komic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurija","family":"Bilalovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9392-3215","authenticated-orcid":false,"given":"Izet","family":"Eminovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Burekovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9707-3537","authenticated-orcid":false,"given":"Amna","family":"Uzunovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabira","family":"Kurtovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6922","published-online":{"date-parts":[[2019,10,30]]},"container-title":["Bosnian Journal of Basic Medical Sciences"],"original-title":[],"link":[{"URL":"http:\/\/www.bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/4391\/1280","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/4391\/1280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T10:43:57Z","timestamp":1572432237000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.bjbms.org\/ojs\/index.php\/bjbms\/article\/view\/4391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,30]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17305\/bjbms.2019.4391","relation":{},"ISSN":["1840-4812","1512-8601"],"issn-type":[{"type":"electronic","value":"1840-4812"},{"type":"print","value":"1512-8601"}],"subject":[],"published":{"date-parts":[[2019,10,30]]}}}