{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:28:43Z","timestamp":1747200523096,"version":"3.40.5"},"reference-count":0,"publisher":"Association of Basic Medical Sciences of FBIH","license":[{"start":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T00:00:00Z","timestamp":1635465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bosn J of Basic Med Sci"],"abstract":"<jats:p>We conducted a prospective open-label cohort study with the aim of examining the effects of the highly \u03b21-selective agent bisoprolol on central aortic systolic pressure (CASP) after the first dose and after 6 weeks\u2019 treatment and whether the CASP response could be predicted from the early response. Chinese patients with primary hypertension (BP \u2265 140\/90 mmHg) on no therapy or background amlodipine were treated with bisoprolol 2.5 mg daily for 6 weeks. Brachial systolic BP (Br-SBP), resting heart rate (HR) and CASP were determined at baseline, 24h after the first dose, and pre-dose after treatment for 6 weeks using the BPro\u00ae device. In 42 patients (age 54 \u00b1 9 years) the mean reductions in CASP and Br-SBP after 6 weeks of treatment were not significantly different from each other at -14.5 \u00b1 12.7 and -15.4 \u00b1 12.9 mmHg (both p&lt;0.01), respectively. Changes in CASP and Br-SBP were highly correlated after the first dose (r = 0.964, p&lt;0.01) and after 6 weeks (r = 0.963, p&lt;0.01) and the reductions in CASP after 6 weeks were also associated with the reduction in CASP after the first dose (r = 0.577, p&lt;0.01). Bisoprolol was shown to effectively reduce CASP and this effect was directly proportional to the reduction in Br-SBP and of a similar magnitude. More favourable CASP responses to long term therapy may be predicted by greater reductions in CASP after the first dose.<\/jats:p>","DOI":"10.17305\/bjbms.2021.6483","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T17:13:38Z","timestamp":1635527618000},"source":"Crossref","is-referenced-by-count":1,"title":["Effect of bisoprolol on central aortic systolic pressure in Chinese hypertensive patients after the initial dose and long term treatment"],"prefix":"10.17305","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6776-7087","authenticated-orcid":false,"given":"Weiwei","family":"Zeng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6717-5444","authenticated-orcid":false,"given":"Brian","family":"Tomlinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6922","published-online":{"date-parts":[[2021,10,29]]},"container-title":["Bosnian Journal of Basic Medical Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/6483\/2410","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.bjbms.org\/ojs\/index.php\/bjbms\/article\/download\/6483\/2410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T17:13:38Z","timestamp":1635527618000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bjbms.org\/ojs\/index.php\/bjbms\/article\/view\/6483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17305\/bjbms.2021.6483","relation":{},"ISSN":["1840-4812","1512-8601"],"issn-type":[{"type":"electronic","value":"1840-4812"},{"type":"print","value":"1512-8601"}],"subject":[],"published":{"date-parts":[[2021,10,29]]}}}