{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T02:50:32Z","timestamp":1780714232799,"version":"3.54.1"},"reference-count":0,"publisher":"Slovenian Chemical Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACSi"],"abstract":"<jats:p>The acid catalyzed hydrolysis of the N-(p-substitutedphenyl) phthalimides in three different acids was investigated at 50.0 \u00b1 0.1 \u00b0C. Two different antioxidant activity tests as DPPH\u2022 and ABTS\u2022+ scavenging activities, and three various enzyme inhibition activity tests as urease, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) inhibition activities, were applied. Compound 3c (2.03 \u03bcg\/mL ) has higher antioxidant activity than other compounds and standards according to DPPH test. In AChE assay, compounds 3a and 3b (13.13 and 9.59 \u03bcg\/mL) has higher enzyme inhibition activity than the standard Galantamine (14.37 \u03bcg\/mL). In BChE and urease tests, all compounds (6.84-13.60 and 10.49-17.73 \u03bcg\/mL) have higher enzyme inhibition activity than the standard Galantamine (49.40 \u03bcg\/mL) and thiourea (26.19 \u03bcg\/mL), respectively. The molecule interaction for each of the three compounds with the active sites of AChE, BChE, and urease enzymes was examined via molecular docking simulations.<\/jats:p>","DOI":"10.17344\/acsi.2022.7808","type":"journal-article","created":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T11:36:02Z","timestamp":1678534562000},"page":"29-43","source":"Crossref","is-referenced-by-count":7,"title":["Kinetic Studies, Antioxidant Activities, Enzyme Inhibition Properties and Molecular Docking of 1,3-Dihydro-1,3-Dioxoisoindole Derivatives"],"prefix":"10.17344","volume":"70","author":[{"given":"Hasan","family":"Yakan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyhan","family":"Ozturk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvan Uyar","family":"Tolgay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semiha","family":"Yenigun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarmad","family":"Marah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugrul","family":"Doruk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tevfik","family":"Ozen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halil","family":"Kutuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7072","published-online":{"date-parts":[[2023,3,20]]},"container-title":["Acta Chimica Slovenica"],"original-title":[],"deposited":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T11:36:09Z","timestamp":1678534569000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.matheo.si\/index.php\/ACSi\/article\/view\/7808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,20]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,3,20]]}},"URL":"https:\/\/doi.org\/10.17344\/acsi.2022.7808","relation":{},"ISSN":["1580-3155"],"issn-type":[{"value":"1580-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,20]]}}}