{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:30:54Z","timestamp":1791264654569,"version":"4.1.0"},"reference-count":0,"publisher":"Slovenian Chemical Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACSi"],"abstract":"<jats:p>Hydrazone compounds have interesting biological activities. In this work, a new hydrazone compound 3,5-dihydroxy-N\u2019-(pyridin-2-ylmethylene)benzohydrazide (HL) was synthesized and characterized by IR, UV-Vis, 1H and 13C NMR spectroscopy. The compound reacts with copper chloride and nickel acetate, respectively, to afford metal complexes [CuCl2(HL)]\u2219CH3OH (1\u2219CH3OH) and [NiL2]\u22192CH3OH\u22192H2O (2\u22192CH3OH\u22192H2O). The complexes were characterized by elemental analysis, and IR and UV-Vis spectroscopy. Structures of HL and the complexes were further confirmed by single crystal X-ray determination. The hydrazone ligand in complex 1 adopts neutral form and coordinates to Cu ion through pyridine nitrogen, imino nitrogen and carbonyl oxygen atoms. The hydrazone ligands in complex 2 adopt monoanionic form and coordinate to Ni ion through pyridine nitrogen, imino nitrogen and enolate oxygen atoms. The Cu atom in complex 1 is in square pyramidal coordination, and the Ni atom in complex 2 is in octahedral coordination. The compounds were tested for their urease inhibitory activities. Complex 1 has remarkable activity on Jack bean urease (IC50 = 0.5 \u00b1 0.1 \u03bcmol L\u20131).<\/jats:p>","DOI":"10.17344\/acsi.2025.9518","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T09:33:38Z","timestamp":1764754418000},"page":"740-747","source":"Crossref","is-referenced-by-count":5,"title":["Synthesis, X-Ray Crystal Structures and Urease Inhibitory Activity of 3,5-Dihydroxy-N\u2019-(pyridin-2-ylmethylene) benzohydrazide and its Copper(II) and Nickel(II) Complexes"],"prefix":"10.17344","volume":"72","author":[{"given":"Zhonglu","family":"You","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoyao","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahua","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niansui","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhui","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7072","published-online":{"date-parts":[[2025,12,18]]},"container-title":["Acta Chimica Slovenica"],"original-title":[],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T09:33:41Z","timestamp":1764754421000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.matheo.si\/index.php\/ACSi\/article\/view\/9518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12,18]]}},"URL":"https:\/\/doi.org\/10.17344\/acsi.2025.9518","relation":{},"ISSN":["1580-3155"],"issn-type":[{"value":"1580-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,18]]}}}