{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:33:08Z","timestamp":1794047588408,"version":"4.8.0"},"reference-count":0,"publisher":"Slovenian Chemical Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACSi"],"abstract":"<jats:p>This study evaluates the photodynamic inactivation potential of a coumarin-functionalized zinc(II) phthalocyanine derivative against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 33591. The antimicrobial and cytotoxic effects of the derivative were assessed under dark and laser-irradiated (658 nm) conditions. Minimum inhibitory concentration (MIC) values were determined, and the photodynamic response was further explored in MRSA-infected HT-29 (human colorectal adenocarcinoma) and HUVEC (human umbilical vein endothelial) cell models. While the derivative exhibited dose-dependent antibacterial activity, the light-induced reduction in colony-forming units (CFU) was moderate, remaining below a tenfold (1-log10) under the tested conditions. In cell-based assays, the compound showed detectable dark cytotoxicity, which was further enhanced upon laser irradiation. The photodynamic cytotoxic response was more pronounced in infected HT-29 cells than in infected HUVEC cells, with flow-cytometric profiles consistent with predominantly necrotic\/late apoptotic cell-death patterns. These findings indicate that the compound exhibits light-enhanced effects in complex infection models; however, further optimization of formulation, photophysical properties, and light dosimetry is required to improve antimicrobial efficacy and selectivity.<\/jats:p>","DOI":"10.17344\/acsi.2025.9638","type":"journal-article","created":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:18:08Z","timestamp":1794046688000},"page":"515-521","source":"Crossref","is-referenced-by-count":0,"title":["Photoinactivation of MRSA ATCC 33591 by antimicrobial photodynamic therapy using coumarin-functionalized zinc(II) phthalocyanine"],"prefix":"10.17344","volume":"73","author":[{"given":"Merve","family":"Bilgin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugba","family":"Elgun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cigdem","family":"Aktas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onur O.","family":"Karagulle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"\u00c7\u0131nar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asiye Gok","family":"Yurttas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7072","published-online":{"date-parts":[[2026,9,25]]},"container-title":["Acta Chimica Slovenica"],"original-title":[],"deposited":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:18:09Z","timestamp":1794046689000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.matheo.si\/index.php\/ACSi\/article\/view\/9638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,9,25]]}},"URL":"https:\/\/doi.org\/10.17344\/acsi.2025.9638","relation":{},"ISSN":["1580-3155"],"issn-type":[{"value":"1580-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,25]]}}}