{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:51:00Z","timestamp":1781797860878,"version":"3.54.5"},"reference-count":0,"publisher":"Slovenian Chemical Society","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACSi"],"abstract":"<jats:p>Hydrazone compounds and their nickel(II) and cadmium(II) complexes have interesting biological activities. To explore new and efficient urease inhibitors, in this work an aroylhydrazone compound N\u2019-(2-Hydroxy-4-methoxybenzylidene)-4-methylbenzohydrazide (HL) and two complexes [Ni2L2(CH3OH)2(OH2)2]Cl2\u00b72CH3OH (1) and [Cd2L2(CH-3COO)2] (2) have been prepared and characterized by elemental analysis, infrared and electronic spectroscopy, as well as single crystal X-ray determination. In addition, 1H and 13C NMR spectroscopy was used for HL. Both complexes are dinuclear compounds. The Ni atoms in complex 1 and Cd atoms in complex 2 are in octahedral coordination. The Cl\u2013 in 1 acts as a counter anion, while the NO3 \u2013 in 2 coordinates to the metal atoms with bidentate form. The urease inhibitory assay reveals that HL has weak activity, while complexes 1 and 2 have IC50 values of 18.2 \u00b1 1.1 \u03bcmol L\u20131 and 0.38 \u00b1 0.12 \u03bcmol L\u20131, respectively. Both complexes have higher activity than the standard drug acetohydroxamic acid (IC50 = 28.1 \u03bcmol L\u20131).<\/jats:p>","DOI":"10.17344\/acsi.2026.9766","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:51:13Z","timestamp":1781794273000},"page":"436-443","source":"Crossref","is-referenced-by-count":0,"title":["N\u2019-(2-Hydroxy-4-methoxybenzylidene)-4- methylbenzohydrazide and its dinuclear nickel(II) and cadmium(II) complexes: Synthesis, crystal structures and urease inhibition"],"prefix":"10.17344","volume":"73","author":[{"given":"Chi","family":"Liu,","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu-Xiu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Fu","family":"Hu,","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7072","published-online":{"date-parts":[[2026,6,20]]},"container-title":["Acta Chimica Slovenica"],"original-title":[],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:51:18Z","timestamp":1781794278000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.matheo.si\/index.php\/ACSi\/article\/view\/9766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,20]]},"references-count":0,"URL":"https:\/\/doi.org\/10.17344\/acsi.2026.9766","relation":{},"ISSN":["1580-3155"],"issn-type":[{"value":"1580-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,20]]}}}