{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:33:03Z","timestamp":1794047583573,"version":"4.8.0"},"reference-count":0,"publisher":"Slovenian Chemical Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACSi"],"abstract":"<jats:p>Neurosteroids modulate the function of \u03b3-aminobutyric acid type A (GABAA) receptors in the brain. We showed that GABAA receptors modulate neurosteroid interactions with VDAC. GABA enhanced [3H]6-AziP labeling of VDAC in a concentration-dependent manner. This effect of GABA was prevented by the GABAA receptor antagonists gabazine and picrotoxin. Studies with brain tissue from mice deficient for VDAC showed that GABA enhanced [3H]6-AziP labeling of VDAC2 and VDAC1. GABA enhanced photolabeling of VDAC in HEK cells expressing \u03b32L-subunit, suggesting that the \u03b32L-subunit is required for the interaction of GABAA receptors with VDAC. VDAC1 and VDAC2 both co-immunoprecipitated with GABAA receptors in rat brain membranes. Collectively, the data provide evidence for a direct signaling pathway between the synaptic plasma membrane GABAA receptor and VDAC, a mitochondrial outer membrane protein.<\/jats:p>","DOI":"10.17344\/acsi.2026.9831","type":"journal-article","created":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:18:08Z","timestamp":1794046688000},"page":"604-614","source":"Crossref","is-referenced-by-count":0,"title":["\u03b3-aminobutyric acid type A receptors modulate neurosteroid binding to the voltage-dependent anion channel"],"prefix":"10.17344","volume":"73","author":[{"given":"Natalia P.","family":"Akentieva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7072","published-online":{"date-parts":[[2026,9,25]]},"container-title":["Acta Chimica Slovenica"],"original-title":[],"deposited":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T10:18:15Z","timestamp":1794046695000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.matheo.si\/index.php\/ACSi\/article\/view\/9831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,9,25]]}},"URL":"https:\/\/doi.org\/10.17344\/acsi.2026.9831","relation":{},"ISSN":["1580-3155"],"issn-type":[{"value":"1580-3155","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,25]]}}}