{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:57:09Z","timestamp":1775473029161,"version":"3.50.1"},"reference-count":33,"publisher":"Medical Association of Zenica-Doboj","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2019,5,10]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;To evaluate the relationship between cardiovascular remodelling and glomerular filtration rate (eGFR) in pre-dialysis chronic kidney disease (CKD) patients without cardiovascular diseases (CVD) and in renal transplant recipients (RTR). &amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; The cross-sectional study included 83 patients with eGFR&amp;amp;lt;60 mL\/min\/1.73m 2 (45 with CKD 3 stage and 38 with CKD 4 stage). Thirty six RTR had eGFR 67.8 (57.3-73.7) mL\/ min\/1.73m 2 and control group consisted of 44 patients with eGFR&amp;amp;gt;60 mL\/min\/1.73m 2. All patients were evaluated by echocardiography and X-ray. &amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Results&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; Left ventricular hypertrophy (LVH) was present in 74.7% CKD patients, most frequently in CKD 4 stage and in RTR. Calcifications of abdominal aorta (CAA) were present in 87% CKD 4, 60% RTR and in 44% CKD 3 patients. Calcifications of the mitral valve were found in 34.2% CKD 4, 25.0% RTR and in 6.7% CKD 3 stage patients. Aortic valve calcifications were most frequently present in CKD 4 stage (26.3%). The LV mass index negatively correlated with eGFR (p&amp;amp;lt;0.001), and positively with parathyroid hormone (p&amp;amp;lt;0.001), phosphorus (p=0.043), age (p&amp;amp;lt;0.001) and diabetes (p=0.043). In multivariate regression analysis the risk factor for calcifications of the mitral and aortic valve, as well as for CAA was the decline in eGFR (p&amp;amp;lt;0.001). &amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusion&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; Renal transplant recipients have a higher incidence of CV remodelling than patients with CKD 3 and less than patients with CKD 4 stage, indicating incomplete regression of CV calcifications and LVH after kidney transplantation. A decrease of renal function represents a significant risk factor for valvular and vascular calcifications occurrence in CKD patients.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1009-19","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T10:20:46Z","timestamp":1713694846000},"page":"216-223","source":"Crossref","is-referenced-by-count":1,"title":["Cardiovascular remodelling in patients with pre-dialysis chronic kidney disease and renal transplant recipients"],"prefix":"10.17392","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2376-9560","authenticated-orcid":false,"given":"Ramajana","family":"Temimovi\u0107","sequence":"first","affiliation":[{"name":"Institute for Occupational Medicine of Canton Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senija","family":"Ra\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Nephrology, Clinical Centre of the University of Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alen","family":"D\u017eubur","sequence":"additional","affiliation":[{"name":"Clinic for Heart Disease, Blood Vessels and Rheumatism, Clinical Centre of the University of Sarajevo;","place":["Sarajevo,Bosnia and Herzegovina"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49509","published-online":{"date-parts":[[2019,5,10]]},"reference":[{"key":"ref1","first-page":"158765","article-title":"Global prevalence of chronic kidney disease -a systematic review and meta-analysis","author":"NHillN","year":"2016","unstructured":"Hill NR, Fatoba ST, Oke JL, Hirst JA, O'Callaghan \nCA, Lasserson DS, Hobbs FDR. 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Curr Osteopor \nRep 2015; 13:206-15.","journal-title":"Curr Osteopor Rep"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1476-511X-13-135","article-title":"Markers of increased cardiovascular risk in patients with chronic kidney disease","author":"AGluba-BrzozkaA","year":"2014","unstructured":"Gluba-Brzozka A, Michalska-Kasiczak M, Franc-\nzyk-Skora B, Nocun M, Banach M, Rysz J. Mark-\ners of increased cardiovascular risk in patients with \nchronic kidney disease. Lipids Health Dis 2014; \n13:135.","journal-title":"Lipids Health Dis"},{"key":"ref13","first-page":"1090","article-title":"Cardiac valve calcification is associated with presence and severity of coronary artery disease in patients with pre-dialysis chronic kidney disease","author":"IKimI","year":"2015","unstructured":"Kim IY, Kim MJ, Lee DW, Lee SB, Shin MJ, Rhee \nH, Yang BY, Song SH, Seong EY, Kwak IS. 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Kidney Int Suppl 2013; 3:1-150.","journal-title":"Kidney Int Suppl"},{"key":"ref17","first-page":"245","article-title":"New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25-year follow-up study","author":"LKauppilaL","year":"1997","unstructured":"Kauppila LI, Polak JF, Cupples LA, Hannan MT, \nKiel DP, Wilson PW. New indices to classify locati-\non, severity and progression of calcific lesions in the \nabdominal aorta: a 25-year follow-up study. Athe-\nrosclerosis 1997; 132:245-50.","journal-title":"Atherosclerosis"},{"key":"ref18","first-page":"1440","article-title":"Chamber Quantification Writing Group; American Society of Echocardiography's Guidelines and Standards Committee; European Association of Echocardiography. 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J Am Soc Echocardiogr"},{"key":"ref19","first-page":"73","article-title":"Left ventricular hypertrophy and geometry in type 2 diabetes patients with chronic kidney disease. An echocardiographic study","author":"MBayauliM","year":"2012","unstructured":"Bayauli MP, Lepira FB, Kayembe PK, M'buyamba-\nKabangu JR. Left ventricular hypertrophy and geo-\nmetry in type 2 diabetes patients with chronic kidney \ndisease. An echocardiographic study. Cardiovasc J \nAfr 2012; 23:73-7.","journal-title":"Cardiovasc J Afr"},{"key":"ref20","first-page":"6259","article-title":"Kidney disease measures and left ventricular structure and function: the atherosclerosis risk in communities study","author":"KMatsushitaK","year":"2017","unstructured":"Matsushita K, Kwak L, Sang Y, Ballew SH, Skali \nH, Shah AM, Coresh J, Solomon S. Kidney disease \nmeasures and left ventricular structure and function: \nthe atherosclerosis risk in communities study. 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Cardiovascular remodelling in \nchronic kidney disease. EMJ Neph 2014; 1:113-9.","journal-title":"EMJ Neph"},{"key":"ref29","first-page":"4310379","article-title":"Vascular calcification in chronic kidney disease: the role of inflammation","author":"KBenzK","year":"2018","unstructured":"Benz K, Hilgers KF, Daniel C, Amann K. Vascular \ncalcification in chronic kidney disease: the role of \ninflammation. Int J Nephrol 2018; 4310379.","journal-title":"Int J Nephrol"},{"key":"ref30","first-page":"891","article-title":"A current understanding of vascular calcification in CKD","author":"NPaloianN","year":"2014","unstructured":"Paloian NJ, Giachelli CM. A current understanding \nof vascular calcification in CKD. Am J Physiol Re-\nnal Physiol 2014; 307:891-900.","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref31","first-page":"521","article-title":"Cross-sectional association of kidney function with valvular and annular calcification: the Framingham heart study","author":"CFoxC","year":"2006","unstructured":"Fox CS, Larson MG, VasanRS, Guo CY, Parise H, \nLevy D, Leip EP, O'donnell CJ, D'Agostino RB Sr, \nBenjamin EJ. Cross-sectional association of kidney \nfunction with valvular and annular calcification: the \nFramingham heart study. J Am Soc Nephrol 2006; \n17:521-7.","journal-title":"J Am Soc Nephrol"},{"key":"ref32","first-page":"9804","article-title":"Risk factors for heart valve calcification in chronic kidney disease","author":"SRongS","year":"2018","unstructured":"Rong S, Qiu X, Jin X, Shang M, Huang Y, Tang Z, \nYuan W. Risk factors for heart valve calcification in \nchronic kidney disease. Medicine (Baltimore) 2018; \n97:e9804.","journal-title":"Medicine (Baltimore)"},{"key":"ref33","first-page":"429","article-title":"Valvular calcification and its relationship to atherosclerosis in chronic kidney disease","author":"YLeskinenY","year":"2009","unstructured":"Leskinen Y, Paana T, Saha H, Groundstroem K, \nLehtimaki T, Kilpinen S, Huhtala H, Airaksinen J. \nValvular calcification and its relationship to atheros-\nclerosis in chronic kidney disease. J Heart Valve Dis \n2009; 18:429-38.","journal-title":"J Heart Valve Dis"}],"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/405\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/405\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:43:54Z","timestamp":1775468634000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/155\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,10]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,5,10]]},"published-print":{"date-parts":[[2019,5,10]]}},"URL":"https:\/\/doi.org\/10.17392\/1009-19","archive":["Internet Archive"],"relation":{"is-cited-by":[{"id-type":"doi","id":"10.1007\/s12410-020-9534-0","asserted-by":"object"}]},"ISSN":["1840-0132","1840-0132"],"issn-type":[{"value":"1840-0132","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5,10]]}}}