{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:57:00Z","timestamp":1775473020851,"version":"3.50.1"},"reference-count":17,"publisher":"Medical Association of Zenica-Doboj","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2019,5,10]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;To describe a case of an eight-year-old boy with chronic Epstein-Barr virus (EBV) hepatitis with incipient cirrhosis, rarely found in practice. &amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; The diagnosis was based on findings of specific IgG serum antibodies and EBV positive liver biopsy. Other etiologies of hepatitis were excluded: autoimmune hepatitis, viral hepatitis A, B, or C, cytomegalovirus (CMV), herpes simplex virus (HSV), adenovirus infection, toxoplasma infection. &amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Results&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; A mild form of infectious mononucleosis with acute hepatitis without icterus was found in the boy first time at the age of three. He got sick again in april 2018 with fever, minor loss of appetite and weakness, skin and sclera were anicteric, no enlarged neck lymph nodes. Ultrasonography of the spleen revealed a spleen diameter of 10.7 cm, while the liver was 11.8 cm. Laboratory findings, sedimentation, blood count, C reactive protein (CRP) were all normal. Ten days and a month later an increase of aminotransferase was noticed. The liver biopsy and PCR EBV DNA were performed six months of disease onset. The disease had lasted for about one more year with loss of strength and an increase of aminotransferase with maximum value of 3-4 times higher than normal one. The therapy was supportive. &amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusion&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; Chronic EBV hepatitis is very rare. In differential diagnosis of hepatitis and unclear febrile conditions, EBV infection should not be forgotten.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1031-19","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T10:20:46Z","timestamp":1713694846000},"page":"190-194","source":"Crossref","is-referenced-by-count":1,"title":["Infectious mononucleosis (Epstein-Barr virus infection) and chronic hepatitis"],"prefix":"10.17392","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7152-6497","authenticated-orcid":false,"given":"Lejla","family":"\u010calki\u0107","sequence":"first","affiliation":[{"name":"School of Medicine, University of Zenica","place":["Zenica,Bosnia and Herzegovina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lejla","family":"Bajramovi\u0107-Omeragi\u0107","sequence":"additional","affiliation":[{"name":"Cantonal Hospital Zenica","place":["Zenica,Bosnia and Herzegovina"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Mujezinovi\u0107","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Zenica","place":["Zenica,Bosnia and Herzegovina"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49509","published-online":{"date-parts":[[2019,5,10]]},"reference":[{"key":"ref1","first-page":"268","article-title":"The interplay between Epstein-Barr virus and B-lymphocytes: implications for infection, immunity, and disease","author":"OHattonO","year":"2014","unstructured":"Hatton OL, Harris-Arnold A, Schaffert S, Krams \nSM, Martinez OM. The interplay between Epstein-\nBarr virus and B-lymphocytes: implications for in-\nfection, immunity, and disease. Immunol Res 2014; \n58:268-76.","journal-title":"Immunol Res"},{"key":"ref2","first-page":"27","article-title":"Epstein-Barr virus-associated malignancies: epidemiologic patterns and etiologic implications","author":"JHsuJ","year":"2000","unstructured":"Hsu JL, Glaser SL. Epstein-Barr virus-associated \nmalignancies: epidemiologic patterns and etiologic \nimplications. Crit Rev Oncol Hematol 2000; 34:27-\n53.","journal-title":"Crit Rev Oncol Hematol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1128\/JVI.77.3.1840-1847.2003","article-title":"Compartmentalization and transmission of multiple Epstein-Barr virus strains in asymptomatic carriers","author":"DSitki-GreenD","year":"2003","unstructured":"Sitki-Green D, Covington M, Raab-Traub N. Com-\npartmentalization and transmission of multiple Ep-\nstein-Barr virus strains in asymptomatic carriers. J \nVirol 2003; 77:1840-7.","journal-title":"J Virol"},{"key":"ref4","first-page":"787","article-title":"The immunology of Epstein-Barr virusinduced disease","author":"GTaylorG","year":"2015","unstructured":"Taylor GS, Long HM, Brooks JM, Rickinson AB, \nHislop AD. The immunology of Epstein-Barr virus-\ninduced disease. Annu Rev Immunol 2015; 33:787-\n821.","journal-title":"Annu Rev Immunol"},{"key":"ref5","first-page":"147","article-title":"Acute Epstein-Barr virus hepatitis without mononucleosis syndrome: a case report","author":"AMoniriA","year":"2017","unstructured":"Moniri A, Tabarsi P, Marjani M, Doosti Z. Acute \nEpstein-Barr virus hepatitis without mononucleosis \nsyndrome: a case report. Gastroenterol Hepatol Bed \nBench 2017; 10:147-9.","journal-title":"Gastroenterol Hepatol Bed Bench"},{"key":"ref6","first-page":"291","article-title":"Analylis of clinical, haematological and biochemical parameters in patient with infectious mononucleosis","author":"P\u010canovi\u0107P","year":"2015","unstructured":"\u010canovi\u0107 P, Vrani\u0107 A, Petrovi\u0107 S, Rakovi\u0107 I, Popov-\nska Jovi\u010di\u0107 B, Hamzagic N. Analylis of clinical, hae-\nmatological and biochemical parameters in patient \nwith infectious mononucleosis. Ser J Exp Clin Res \n2015; 16:291-5.","journal-title":"Ser J Exp Clin Res"},{"key":"ref7","first-page":"14","article-title":"Epstein-Barr virusni hepatitis sa pojavom ikterusa -prikaz slu\u010daja","author":"VVukovi\u0107V","year":"2010","unstructured":"Vukovi\u0107 VR, Mijailovi\u0107 Z, Borov\u010danin N. Epstein-\nBarr virusni hepatitis sa pojavom ikterusa -prikaz \nslu\u010daja. Med \u010das (Kragujevac) 2010; 1:14-8.","journal-title":"Med \u010das (Kragujevac)"},{"issue":"4","key":"ref8","first-page":"178","article-title":"Epstein-Barr virusni hepatitis sa pojavom ikterusaprikaz slu\u010daja","author":"P\u010canovi\u0107P","year":"2006","unstructured":"\u010canovi\u0107 P, Gajovi\u0107 O, Todorovi\u0107 Z, Mijailovi\u0107 \u017d. \nEpstein-Barr virusni hepatitis sa pojavom ikterusa -\nprikaz slu\u010daja. Med Preg 2006; 3-4:178-82.","journal-title":"Med Preg"},{"key":"ref9","first-page":"4130","article-title":"Epstein-Barr virus: silent companion or causative agent of chronic liver disease?","author":"MPetrovaM","year":"2010","unstructured":"Petrova M, Kamburov V. Epstein-Barr virus: silent \ncompanion or causative agent of chronic liver disea-\nse? World J Gastroenterol 2010; 16:4130-4.","journal-title":"World J Gastroenterol"},{"issue":"8","key":"ref10","first-page":"362","article-title":"Hroni\u010dna infektivna mononukleoza","author":"SBrki\u0107S","year":"2003","unstructured":"Brki\u0107 S, Jovanovi\u0107 J, Preveden T. Hroni\u010dna infek-\ntivna mononukleoza. Med Pregl 2003; 7-8:362-72.","journal-title":"Med Pregl"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/infdis\/157.3.405","article-title":"The chronic mononucleosis syndrome","author":"SStrausS","year":"1988","unstructured":"Straus SE. The chronic mononucleosis syndrome. J \nInfect Dis 1988; 157:405-12.","journal-title":"J Infect Dis"},{"key":"ref12","first-page":"1867","article-title":"Chronic Active Epstein-Barr virus disease","author":"HKimuraH","year":"2017","unstructured":"Kimura H, Cohen JI. Chronic Active Epstein-Barr \nvirus disease. Front Immunol 2017; 8:1867.","journal-title":"Front Immunol"},{"key":"ref13","first-page":"307","article-title":"Quantification of Epstein-Barr virus DNA is helpful for evaluation of chronic active Epstein-Barr virus infection","author":"YSakamotoY","year":"2012","unstructured":"Sakamoto Y, Mariya Y, Kubo K. Quantification of \nEpstein-Barr virus DNA is helpful for evaluation of \nchronic active Epstein-Barr virus infection. Tohoku \nJ Exp Med 2012; 227:307-11.","journal-title":"Tohoku J Exp Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.5501\/wjv.v1.i1.31","article-title":"Serological diagnosis of Epstein-Barr virus infection: problems and solutions","author":"MDe PaschaleM","year":"2012","unstructured":"De Paschale M, Clerici P. Serological diagnosis of \nEpstein-Barr virus infection: problems and soluti-\nons. World J Virol 2012; 1:31-43.","journal-title":"World J Virol"},{"key":"ref15","first-page":"5711","article-title":"Chronic Epstein-Barr virus-related hepatitis in immunocompetent patients","author":"MPetrovaM","year":"2006","unstructured":"Petrova M, Muhtarova M, Nikolova M, Magaev S, \nTaskov H, Nikolovska D, Krastev Z. Chronic Epste-\nin-Barr virus-related hepatitis in immunocompetent \npatients. World J Gastroenterol 2006; 12:5711-6.","journal-title":"World J Gastroenterol"},{"key":"ref16","first-page":"879","article-title":"The role of Epstein-Barr virus in acute and chronic hepatitis","author":"UDrebberU","year":"2006","unstructured":"Drebber U, Kasper HU, Krupacz J, Haferkamp K, \nKern MA, Steffen HM, Quasdorff M, Zur Hausen \nA, Odenthal M, Dienes HP. The role of Epstein-Barr \nvirus in acute and chronic hepatitis. J Hepatol 2006; \n44:879-85.","journal-title":"J Hepatol"},{"key":"ref17","first-page":"10","article-title":"Chronic active EBV infection: the experience of the Samsung Medical Center in South Korea","author":"TLeeT","year":"2016","unstructured":"Lee TH, Ko YH. Chronic active EBV infection: the \nexperience of the Samsung Medical Center in South \nKorea. Bol Med Hosp Infant Mex 2016; 73:10-7.","journal-title":"Bol Med Hosp Infant Mex"}],"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/186\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/186\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:43:51Z","timestamp":1775468631000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/137\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,10]]},"references-count":17,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,5,10]]},"published-print":{"date-parts":[[2019,5,10]]}},"URL":"https:\/\/doi.org\/10.17392\/1031-19","archive":["Internet Archive"],"relation":{},"ISSN":["1840-0132","1840-0132"],"issn-type":[{"value":"1840-0132","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5,10]]}}}