{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:57:04Z","timestamp":1775473024433,"version":"3.50.1"},"reference-count":27,"publisher":"Medical Association of Zenica-Doboj","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2019,5,10]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim &amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt;To examine the effects of therapeutic hypothermia on the outcome of patients with the diagnosis of out-of-hospital cardiac arrest (OHCA). &amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; The study included 76 patients who were hospitalised at the Medical Intensive Care Unit (MICU) of the Clinical Centre University of Sarajevo, with the diagnosis of out-of-hospital cardiac arrest, following the return of spontaneous circulation. Therapeutic hypothermia was performed with an average temperature of 33 o C (32.3-34.1 o C) on the patients who had coma, according to the Glasgow Coma Scale (GCS). &amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Results&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; Multiple organ dysfunction syndrome (MODS) significantly affected survival (p=0.0001), as its presence reduced patients&amp;#039; survival by 96%. In addition, ventricular fibrillation (VF) as the presenting rhythm, also significantly affected survival (p=0.019). A degree of patient&amp;#039;s coma, as measured by the GCS, significantly affected survival (p=0.011). For each increasing point on the GCS, the chance for survival increased twice. Moreover, other physiological factors such as the pH and the lactate serum levels significantly affected patients&amp;#039; survival (p=0.012 and p=0.01, respectively). &amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusion&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;In patients with the diagnosis of OHCA who underwent to the treatment with therapeutic hypothermia, verified VF as a presenting rhythm was a positive predictive factor for their outcome. Therefore, therapeutic hypothermia represents an option of therapeutic modality for this type of patients.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1040-19","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T10:20:46Z","timestamp":1713694846000},"page":"179-184","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic hypothermia as a treatment option after out-of hospital cardiac arrest: our experience"],"prefix":"10.17392","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4677-8489","authenticated-orcid":false,"given":"Amer","family":"Iglica","sequence":"first","affiliation":[{"name":"Clinical Centre University of Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Intensive Care Unit, Clinic for Heart, Blood Vessel and Rheumatic Diseases"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amina","family":"Godinjak","sequence":"additional","affiliation":[{"name":"Clinical Centre University of Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Clinic for Emergency Medicine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edin","family":"Begi\u0107","sequence":"additional","affiliation":[{"name":"General Hospital \u2018\u2019Prim.dr. Abdulah Naka\u0161\u2019\u2019","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Department of Cardiology"]},{"name":"School of Medicine, Sarajevo School of Science and Technology","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Department of Pharmacology"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enisa","family":"Hod\u017ei\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Heart, Blood Vessel and Rheumatic Diseases, Clinical Centre University of Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Intensive Care Unit"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faris","family":"Zvizdi\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Heart, Blood Vessel and Rheumatic Diseases, Clinical Centre University of Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Intensive Care Unit"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nihad","family":"Kukavica","sequence":"additional","affiliation":[{"name":"Clinic for Heart, Blood Vessel and Rheumatic Diseases, Clinical Centre University of Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Intensive Care Unit"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenana","family":"Aganovi\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Heart, Blood Vessel and Rheumatic Diseases, Clinical Centre University of Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Intensive Care Unit"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirvana","family":"\u0160abanovi\u0107-Bajramovi\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Heart, Blood Vessel and Rheumatic Diseases, Clinical Centre University of Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Intensive Care Unit"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adis","family":"Kukuljac","sequence":"additional","affiliation":[{"name":"General Hospital \u2018\u2019Prim.dr. Abdulah Naka\u0161\u2019\u2019 Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Department of Orthopaedics"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Refet","family":"Gojak","sequence":"additional","affiliation":[{"name":"Clinical Centre University of Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Clinic for Infectious diseases"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49509","published-online":{"date-parts":[[2019,5,10]]},"reference":[{"key":"ref1","article-title":"Extracorporeal life support following out-of-hospital refractory cardiac arrest","author":"LeGuenLe","year":"2011","unstructured":"Le Guen M, Nicolas-Robin A, Carreira S, Raux M, \nLeprince P, Riou B, Langeron O. Extracorporeal life \nsupport following out-of-hospital refractory cardiac \narrest. Crit Care 2011; 15:R29.","journal-title":"Crit Care"},{"key":"ref2","first-page":"74","article-title":"Out-of-hospital cardiac arrest patients treated with cardiopulmonary resuscitation using extracorporeal membrane oxygenation: focus on survival rate and neurologic outcome","author":"JLeeJ","year":"2016","unstructured":"Lee JJ, Han SJ, Kim HS, Hong KS, Choi HH, Park \nKT, Seo JY, Lee TH, Kim HC, Kim S, Lee SH, \nHwang SM, Ha SO. Out-of-hospital cardiac arrest \npatients treated with cardiopulmonary resuscitation \nusing extracorporeal membrane oxygenation: focus \non survival rate and neurologic outcome. Scand J Tra-\numa Resusc Emerg Med 2016; 24:74.","journal-title":"Scand J Trauma Resusc Emerg Med"},{"key":"ref3","first-page":"328","article-title":"Therapeutic hypothermia for out-of-hospital cardiac arrest: An analysis comparing cooled and not cooled groups at a Canadian center","author":"DMacleanD","year":"2012","unstructured":"Maclean DA, Stevenson RS, Bata I, Green RS. Thera-\npeutic hypothermia for out-of-hospital cardiac arrest: \nAn analysis comparing cooled and not cooled groups \nat a Canadian center. J Emerg Trauma Shock 2012; \n5:328-32.","journal-title":"J Emerg Trauma Shock"},{"key":"ref4","first-page":"557","article-title":"Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia","author":"SBernardS","year":"2002","unstructured":"Bernard SA, Gray TW, Buist MD, Jones BM, Silve-\nster W, Gutteridge G, Smith K. Treatment of comato-\nse survivors of out-of-hospital cardiac arrest with in-\nduced hypothermia. N Engl J Med 2002; 346:557-63.","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1017\/S026502150700333X","article-title":"Hypothermia and neurological outcome after cardiac arrest: State of the art","author":"KPoldermanK","year":"2008","unstructured":"Polderman KH. Hypothermia and neurological outco-\nme after cardiac arrest: State of the art. Eur J Anae-\nsthesiol 2008; 42:23-30.","journal-title":"Eur J Anaesthesiol"},{"key":"ref6","first-page":"26","article-title":"Therapeutic hypothermia, still","author":"AGibsonA","year":"2013","unstructured":"Gibson A, Andrews PJ. Therapeutic hypothermia, \nstill \"too cool to be true?\". F1000Prime Rep 2013 \n5:26."},{"key":"ref7","first-page":"1","article-title":"American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care","author":"Ecc Committee","year":"2005. 2005","unstructured":"ECC Committee, Subcommittees and Task Forces \nof the American Heart Association. 2005 American \nHeart Association Guidelines for Cardiopulmonary \nResuscitation and Emergency Cardiovascular Care. \nCirculation 2005; 112: IV1-203.","journal-title":"Circulation"},{"key":"ref8","first-page":"525","article-title":"Induced hypothermia following out-of-hospital cardiac arrest; initial experience in a community hospital","author":"BScottB","year":"2006","unstructured":"Scott BD, Hogue T, Fixley MS, Adamson PB. Indu-\nced hypothermia following out-of-hospital cardiac \narrest; initial experience in a community hospital. \nClin Cardiol 2006 29:525-9.","journal-title":"Clin Cardiol"},{"key":"ref9","first-page":"465","article-title":"Part 8: Post-cardiac arrest care: 2015 American Heart Association Guidelines Update for cardiopulmonary resuscitation and emergency cardiovascular care","author":"CCallawayC","year":"2015","unstructured":"Callaway CW, Donnino MW, Fink EL, Geocadin RG, \nGeocadin RG, Golan E, Kern KB, Leary M, Meurer \nWJ, Peberdy MA, Thompson TM, Zimmerman JL. \nPart 8: Post-cardiac arrest care: 2015 American Heart \nAssociation Guidelines Update for cardiopulmonary \nresuscitation and emergency cardiovascular care. Cir-\nculation 2015; 132:S465-82.","journal-title":"Circulation"},{"key":"ref10","first-page":"844","article-title":"The Glasgow Coma Scale at 40 years: standing the test of time","author":"GTeasdaleG","year":"2014","unstructured":"Teasdale G, Maas A, Lecky F, Manley G, Stocchetti \nN, Murray G. The Glasgow Coma Scale at 40 ye-\nars: standing the test of time. Lancet Neurol 2014; \n13:844-54.","journal-title":"Lancet Neurol"},{"key":"ref11","first-page":"1219","article-title":"European Resuscitation Council Guidelines for Resuscitation 2010 Section 1. Executive summary","author":"JNolanJ","year":"2010","unstructured":"Nolan JP, Soar J, Zideman DA, Biarent D, Bossaert \nLL, Deakin C, Koster RW, Wyllie J, B\u00f6ttiger B; ERC \nGuidelines Writing Group. European Resuscitation \nCouncil Guidelines for Resuscitation 2010 Section 1. \nExecutive summary. Resuscitation 2010 81:1219-76.","journal-title":"Resuscitation"},{"key":"ref12","first-page":"1876","article-title":"Recent trends in survival from out-of-hospital cardiac arrest in the United States","author":"PChanP","year":"2014","unstructured":"Chan PS, McNally B, Tang F, Kellermann A, the CA-\nRES Surveillance Group. Recent trends in survival \nfrom out-of-hospital cardiac arrest in the United Sta-\ntes. Circulation 2014; 130:1876-82.","journal-title":"Circulation"},{"key":"ref13","first-page":"1912","article-title":"American Heart Association Get with the Guidelines-Resuscitation Investigators. Trends in survival after in-hospital cardiac arrest","author":"SGirotraS","year":"2012","unstructured":"Girotra S, Nallamothu BK, Spertus JA, Li Y, \nKrumholz HM, Chan PS; American Heart Associati-\non Get with the Guidelines-Resuscitation Investiga-\ntors. Trends in survival after in-hospital cardiac arrest. \nN Engl J Med 2012; 367:1912-20.","journal-title":"N Engl J Med"},{"key":"ref14","first-page":"40","article-title":"Treatment and outcome in post-resuscitation care after out-of-hospital cardiac arrest when a modern therapeutic approach was introduced","author":"MWerlingM","year":"2007","unstructured":"Werling M, Thor\u00e9n AB, Axelsson C, Herlitz J. Tre-\natment and outcome in post-resuscitation care after \nout-of-hospital cardiac arrest when a modern thera-\npeutic approach was introduced. Resuscitation 2007; \n73:40-5","journal-title":"Resuscitation"},{"key":"ref15","first-page":"123","article-title":"State-specific mortality from sudden cardiac death--United States","year":"1999. 2002","unstructured":"Centers for Disease Control and Prevention (CDC). \nState-specific mortality from sudden cardiac death-\n-United States, 1999. MMWR Morb Mortal Wkly \nRep 2002; 51:123-6.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref16","first-page":"1122","article-title":"Out-of-hospital cardiac arrests of non-cardiac origin. Epidemiology and outcome","author":"MKuismaM","year":"1997","unstructured":"Kuisma M, Alasp\u00e4\u00e4 A. Out-of-hospital cardiac arrests \nof non-cardiac origin. Epidemiology and outcome. \nEur Heart J 1997; 18:1122-8.","journal-title":"Eur Heart J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.ajem.2016.05.060","article-title":"Outcome of patients receiving CPR in the ED of an urban academic hospital","author":"NChokengarmwongN","year":"2016","unstructured":"Chokengarmwong N, Ortiz LA, Raja A, Goldstein \nJN, Huang F, Yeh DD. Outcome of patients receiving \nCPR in the ED of an urban academic hospital. Am J \nEmerg 2016; 34:1595-9.","journal-title":"Am J Emerg"},{"key":"ref18","first-page":"76","article-title":"Resuscitation Outcomes Consortium Investigators. Effect of gender on outcome of out of hospital cardiac arrest in the Resuscitation Outcomes Consortium","author":"LMorrisonL","year":"2016","unstructured":"Morrison LJ, Schmicker RH, Weisfeldt ML, Bigham \nBL, Berg RA, Topjian AA, Abramson BL, Atkins DL, \nEgan D, Sopko G, Rac VE; Resuscitation Outcomes \nConsortium Investigators. Effect of gender on outco-\nme of out of hospital cardiac arrest in the Resusci-\ntation Outcomes Consortium. Resuscitation 2016; \n100:76-81.","journal-title":"Resuscitation"},{"key":"ref19","first-page":"66","article-title":"Bridging the gender gap: Insights from a contemporary analysis of sex-related differences in the treatment and outcomes of patients with acute coronary syndromes","author":"SPoonS","year":"2011","unstructured":"Poon S, Goodman SG, Yan RT, Bugiardini R, Bier-\nman AS, Eagle KA, Johnston N, Huynh T, Grondin \nFR, Schenck-Gustafsson K, Yan AT. Bridging the \ngender gap: Insights from a contemporary analysis of \nsex-related differences in the treatment and outcomes \nof patients with acute coronary syndromes. Am Heart \nJ 2011; 163:66-73.","journal-title":"Am Heart J"},{"key":"ref20","first-page":"1503","article-title":"Differential survival for men and women from out-of-hospital cardiac arrest varies by age: results from the OPALS study","author":"BSafdarB","year":"2014","unstructured":"Safdar B, Stolz U, Stiell IG, Cone DC, Bobrow BJ, \ndeBoehr M, Dreyer J, Maloney J, Spaite DW. Diffe-\nrential survival for men and women from out-of-hos-\npital cardiac arrest varies by age: results from the \nOPALS study. Acad Emerg Med 2014; 21:1503-11.","journal-title":"Acad Emerg Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"11607","DOI":"10.1097\/MD.0000000000011607","article-title":"An analysis of the relationship between the applied medical rescue actions and the return of spontaneous circulation in adults with out-of-hospital sudden cardiac arrest","author":"KNadolnyK","year":"2018","unstructured":"Nadolny K, Szarpak L, Gotlib J, Panczyk M, Ster-\nlinski M, Ladny JR, Smereka J, Galazkowski R. An \nanalysis of the relationship between the applied me-\ndical rescue actions and the return of spontaneous cir-\nculation in adults with out-of-hospital sudden cardiac \narrest. Medicine (Baltimore) 2018; 97:e11607.","journal-title":"Medicine (Baltimore)"},{"key":"ref22","first-page":"1","article-title":"Prognostic significance of spontaneous shockable rhythm conversion in adult out-of-hospital cardiac arrest patients with initial non-shockable heart rhythms: A systematic review and meta-analysis","author":"SLuoS","year":"2017","unstructured":"Luo S, Zhang Y, Zhang W, Zheng R, Tao J, Xiong \nY. Prognostic significance of spontaneous shocka-\nble rhythm conversion in adult out-of-hospital car-\ndiac arrest patients with initial non-shockable heart \nrhythms: A systematic review and meta-analysis. Re-\nsuscitation 2017; 121:1-8."},{"key":"ref23","first-page":"8","article-title":"Effects of in-hospital low targeted temperature after out of hospital cardiac arrest: A systematic review with meta-analysis of randomized clinical trials","author":"MVargasM","year":"2015","unstructured":"Vargas M, Servillo G, Sutherasan Y, Rodr\u00edguez-\nGonz\u00e1lez R, Brunetti I, Pelosi P. Effects of in-hospital \nlow targeted temperature after out of hospital cardiac \narrest: A systematic review with meta-analysis of ran-\ndomized clinical trials. Resuscitation 2015; 91:8-18.","journal-title":"Resuscitation"},{"key":"ref24","first-page":"43","article-title":"Disseminated intravascular coagulation with the fibrinolytic phenotype predicts the outcome of patients with out-of-hospital cardiac arrest","author":"TWadaT","year":"2016","unstructured":"Wada T, Gando S, Ono Y, Maekawa K, Katabami \nK, Hayakawa M, Sawamura A. Disseminated intra-\nvascular coagulation with the fibrinolytic phenotype \npredicts the outcome of patients with out-of-hospital \ncardiac arrest. Thromb J 2016; 14:43.","journal-title":"Thromb J"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"404","DOI":"10.5455\/medarh.2017.71.404-407","article-title":"Hyperlactatemia and the importance of repeated lactate measurements in critically ill patients","author":"AGodinjakA","year":"2017","unstructured":"Godinjak A, Jusufovic S, Rama A, Iglica A, Zvizdic \nF, Kukuljac A, Tancica I, Rozajac S. Hyperlactatemia \nand the importance of repeated lactate measurements \nin critically ill patients. Med Arch 2017; 71:404-7.","journal-title":"Med Arch"},{"key":"ref26","first-page":"181","article-title":"Induced hypothermia is underused after resuscitation from cardiac arrest: a current practice survey","author":"BAbellaB","year":"2005","unstructured":"Abella BS, Rhee JW, Huang KN, Vanden Hoek TL, \nBecker LB. Induced hypothermia is underused after \nresuscitation from cardiac arrest: a current practice \nsurvey. Resuscitation 2005; 64:181-6.","journal-title":"Resuscitation"},{"key":"ref27","first-page":"244","article-title":"Therapeutic hypothermia use among health care providers in 2 developing countries","author":"JVaronJ","year":"2008","unstructured":"Varon J, Acosta P. Therapeutic hypothermia use \namong health care providers in 2 developing countri-\nes. Am J Emerg Med 2008; 26:244.","journal-title":"Am J Emerg Med"}],"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/129\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/129\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:43:52Z","timestamp":1775468632000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/146\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,10]]},"references-count":27,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,5,10]]},"published-print":{"date-parts":[[2019,5,10]]}},"URL":"https:\/\/doi.org\/10.17392\/1040-19","archive":["Internet Archive"],"relation":{},"ISSN":["1840-0132","1840-0132"],"issn-type":[{"value":"1840-0132","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5,10]]}}}