{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:58:47Z","timestamp":1775473127495,"version":"3.50.1"},"reference-count":22,"publisher":"Medical Association of Zenica-Doboj","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2019,9,22]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; To investigate the relations between hormonal status of the thyroid gland and mineral bone density in women in menopause with or without osteoporosis. &amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt;The study included 120 postmenopausal women, who were divided into two groups. Group I included postmenopausal patients with osteoporosis, of whom 30 were in the early stages of postmenopause, and 30 of them where in the late postmenopausal phase. The second group included patients with preserved bone mass, of which 30 were in the early stage of postmenopause, and 30 were in the late postmenopausal phase. Bone densitometry (DEXA) was performed for all patients, along with analysis of the level of follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3).&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt; Results&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt;A statistically significant correlation between TSH level and mineral bone density in the lumbar spine level (r=0.27) was found in early postmenopausal women (r &amp;amp;lt;0.05), TSH and T-score at the level of the lumbar spine (r=0.31) (p&amp;amp;lt;0.05), as well as between TSH and mineral content of the femur bone (r=0.29; &amp;amp;lt;0.05). There was statistically significant independent association between thyroxine and mineral bone density at the lumbar spine level in the late postmenopausal women (&amp;amp;szlig;=0.29; p=0.025). &amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusion &amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt;In the early postmenopausal phase, TSH was associated with mineral bone density in the lumbar spine and in the area of the femur.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1056-20","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T10:28:16Z","timestamp":1713695296000},"page":"35-40","source":"Crossref","is-referenced-by-count":2,"title":["Influence of thyroid hormones on bone density"],"prefix":"10.17392","volume":"17","author":[{"given":"Alden","family":"Begi\u0107","sequence":"first","affiliation":[{"name":"Clinic for Heart, Blood Vessel and Rheumatic Diseases","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Department for Angiology"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7112-9694","authenticated-orcid":false,"given":"Amela","family":"Begi\u0107","sequence":"additional","affiliation":[{"name":"Clinical Centre of the University of Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Clinic for Nuclear Medicine and Endocrinology"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajla","family":"Arnautovi\u0107-Halimi\u0107","sequence":"additional","affiliation":[{"name":"Clinical Centre of the University of Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Clinic for Nuclear Medicine and Endocrinology"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49509","published-online":{"date-parts":[[2019,9,22]]},"reference":[{"key":"ref1","first-page":"483","article-title":"Physiology of bone loss","author":"BClarkeB","year":"2010","unstructured":"Clarke BL, Khosla S. Physiology of bone loss. Radi-\nol Clin North Am 2010; 48:483-95.","journal-title":"Radiol Clin North Am"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.bpobgyn.2013.02.005","article-title":"The clinical consequences of an ageing world and preventive strategies","author":"BLunenfeldB","year":"2013","unstructured":"Lunenfeld B, Stratton P. The clinical consequences \nof an ageing world and preventive strategies. Best \nPract Res Clin Obstet Gynaecol 2013; 27:643-59.","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"ref3","article-title":"Postmenopausal syndrome","author":"PDalalP","unstructured":"Dalal PK, Agarwal M. Postmenopausal syndro-\nme."},{"key":"ref4","first-page":"222","year":"2015","unstructured":"Indian J Psychiatry 2015; 57:S222-32.","journal-title":"Indian J Psychiatry"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"402","DOI":"10.5312\/wjo.v5.i4.402","article-title":"Complications of hip fractures: A review","author":"PCarpinteroP","year":"2014","unstructured":"Carpintero P, Caeiro JR, Carpintero R, Morales A, \nSilva S, Mesa M. Complications of hip fractures: A \nreview. World J Orthop 2014; 5:402-11.","journal-title":"World J Orthop"},{"key":"ref6","first-page":"3173","article-title":"Thyroid function within the upper normal range is associated with reduced bone mineral density and increased risk of nonvertebral fractures in healthy euthyroid postmenopausal women","author":"EMurphyE","year":"2010","unstructured":"Murphy E, Gl\u00fcer CC, Reid DM, Felsenberg D, Roux \nC, Eastell R, Williams GR. Thyroid function within \nthe upper normal range is associated with reduced \nbone mineral density and increased risk of nonver-\ntebral fractures in healthy euthyroid postmenopausal \nwomen. J Clin Endocrinol Metab 2010; 95:3173-81.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref7","first-page":"86","article-title":"Low normal TSH levels are associated with low bone mineral density in healthy postmenopausal women","author":"DKimD","year":"2006","unstructured":"Kim DJ, Khang YH, Koh JM, Shong YK, Kim GS. \nLow normal TSH levels are associated with low \nbone mineral density in healthy postmenopausal wo-\nmen. Clin Endocrinol (Oxf) 2006; 64:86-90.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref8","first-page":"113","article-title":"Thyroid-stimulating hormone within normal range does not affect bone turnover in euthyroid postmenopausal women with osteoporotic fracture -a preliminary report","author":"APaterA","year":"2011","unstructured":"Pater A, Nowacki W, Sypniewska G. Thyroid-sti-\nmulating hormone within normal range does not \naffect bone turnover in euthyroid postmenopausal \nwomen with osteoporotic fracture -a preliminary \nreport. EJIFCC 2011; 22:113-7.","journal-title":"EJIFCC"},{"key":"ref9","first-page":"575","article-title":"Thyroid function and bone mineral density among Indian subjects","author":"RMarwahaR","year":"2012","unstructured":"Marwaha RK, Garg MK, Tandon N, Kanwar R, Na-\nrang A, Sastry A, Bhadra K. Thyroid function and \nbone mineral density among Indian subjects. Indian \nJ Endocrinol Metab 2012; 16:575-9.","journal-title":"Indian J Endocrinol Metab"},{"key":"ref10","first-page":"561","article-title":"Risk for fracture in women with low serum levels of thyroid-stimulating hormone","author":"DBauerD","year":"2001","unstructured":"Bauer DC, Ettinger B, Nevitt MC, Stone KL; Study \nof Osteoporotic Fractures Research Group. Risk for \nfracture in women with low serum levels of thyro-\nid-stimulating hormone. Ann Intern Med 2001; \n134:561-8.","journal-title":"Ann Intern Med"},{"key":"ref11","first-page":"569","article-title":"Association between thyroid hormone levels, the number of circulating osteoprogenitor cells, and bone mineral density in euthyroid postmenopausal women","author":"MPirroM","year":"2012","unstructured":"Pirro M, Manfredelli MR, Scarponi AM, Lupattelli \nG, Bagaglia F, Melis F, Mannarino E.Association \nbetween thyroid hormone levels, the number of \ncirculating osteoprogenitor cells, and bone mineral \ndensity in euthyroid postmenopausal women. Meta-\nbolism 2012; 61:569-76.","journal-title":"Metabolism"},{"key":"ref12","first-page":"337","article-title":"Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis","author":"PGarneroP","year":"1996","unstructured":"Garnero P, Sornay-Rendu E, Chapuy MC, Delmas \nPD. Increased bone turnover in late postmenopau-\nsal women is a major determinant of osteoporosis. J \nBone Miner Res 1996; 11:337-49.","journal-title":"J Bone Miner Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1365-2265.2007.03016.x","article-title":"Effects of serum TSH and FT4 levels and the TSHR-Asp727Glu polymorphism on bone: the Rotterdam Study","author":"WVan Der DeureW","year":"2008","unstructured":"van der Deure WM, Uitterlinden AG, Hofman \nA, Rivadeneira F, Pols HA, Peeters RP, Visser TJ. \nEffects of serum TSH and FT4 levels and the TSHR-\nAsp727Glu polymorphism on bone: the Rotterdam \nStudy. Clin Endocrinol (Oxf) 2008; 68:175-81.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref14","first-page":"12","article-title":"Biochemical markers of bone remodeling correlate negatively with circulating TSH in postmenopausal women","author":"IZovkovaI","year":"2008","unstructured":"Zovkova I, Hill M. Biochemical markers of bone re-\nmodeling correlate negatively with circulating TSH \nin postmenopausal women. Endocr Regul 2008; \n42:12-7","journal-title":"Endocr Regul"},{"key":"ref15","first-page":"511","article-title":"Relationship between subclinical thyroid dysfunction and femoral neck bone mineral density in women","author":"WLeeW","year":"2006","unstructured":"Lee WY. Relationship between subclinical thyroid \ndysfunction and femoral neck bone mineral density \nin women. Arch Med Res 2006; 37:511-6","journal-title":"Arch Med Res"},{"key":"ref16","first-page":"P328","article-title":"T3 rather than TSH mediates the effects of altered thyroid status on bone turnover in man","author":"EMurphyE","year":"2007","unstructured":"Murphy E, Williams GR. T3 rather than TSH media-\ntes the effects of altered thyroid status on bone tur-\nnover in man. Endocrine Abstracts 2007; 13:P328.","journal-title":"Endocrine Abstracts"},{"key":"ref17","first-page":"151","article-title":"TSH is a negative regulator of skeletal remodeling","author":"EAbeE","year":"2003","unstructured":"Abe E, Marians RC, Yu W, Wu XB, Ando T, Li Y, \nIqbal J, Eldeiry L, Rajendren G, Blair HC, Davies \nTF, Zaidi M. TSH is a negative regulator of skeletal \nremodeling. Cell 2003; 115:151-62.","journal-title":"Cell"},{"key":"ref18","first-page":"1531","article-title":"Effects of menopuseon femoral and vertebral bone loss","author":"JPouillesJ","year":"1995","unstructured":"Pouilles JM, Tremollieres F, Ribot C. Effects of me-\nnopuseon femoral and vertebral bone loss. J Bone \nMiner Res 1995; 10:1531-6.","journal-title":"J Bone Miner Res"},{"key":"ref19","article-title":"Thyroid stimulating hormone (TSH) may serve as a novel bone anabolic agent for postmenopausal osteoporosis","author":"KSampathK","year":"2006","unstructured":"Sampath KT, \u0160imic P, Sendak R, Draca N, Schiavi \nS, McPherson J, Giljevic Z, Vukicevic S. Thyroid \nstimulating hormone (TSH) may serve as a novel \nbone anabolic agent for postmenopausal osteoporo-\nsis. Calcif Tissue Int 2006; 78:S35.","journal-title":"Calcif Tissue Int"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13044-014-0012-0","article-title":"The influence of thyroid dysfunction on bone metabolism","author":"DTuchendlerD","year":"2014","unstructured":"Tuchendler D, Bolanowski M. The influence of \nthyroid dysfunction on bone metabolism. Thyroid \nRes 2014; 7:12.","journal-title":"Thyroid Res"},{"key":"ref21","first-page":"99","article-title":"Thyroid diseases and bone health","author":"GWilliamsG","year":"2018","unstructured":"Williams GR, Bassett JHD. Thyroid diseases and \nbone health. J Endocrinol Invest 2018; 41:99-109","journal-title":"J Endocrinol Invest"},{"key":"ref22","first-page":"135","article-title":"Role of thyroid hormones in skeletal development and bone maintenance","author":"JBassettJ","year":"2016","unstructured":"Bassett JH, Williams GR. Role of thyroid hormones \nin skeletal development and bone maintenance. En-\ndocr Rev 2016; 37:135-187.","journal-title":"Endocr Rev"}],"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/44\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/44\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:45:06Z","timestamp":1775468706000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/429\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,22]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,9,22]]},"published-print":{"date-parts":[[2019,9,22]]}},"URL":"https:\/\/doi.org\/10.17392\/1056-20","archive":["Internet Archive"],"relation":{"is-cited-by":[{"id-type":"doi","id":"10.7759\/cureus.26353","asserted-by":"object"}]},"ISSN":["1840-0132","1840-0132"],"issn-type":[{"value":"1840-0132","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9,22]]}}}