{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:58:30Z","timestamp":1775473110357,"version":"3.50.1"},"reference-count":41,"publisher":"Medical Association of Zenica-Doboj","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2019,9,22]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; Acute rhinosinusitis (AR) is of viral aetiology and only 0.5-2% develop into acute bacterial rhinosinusitis. Herbal therapy is a promising alternative in acute bacterial rhinosinusitis treatment. The aim of this study was to evaluate the effect of ethanol extract of Poguntano leaves (EEPL) to procalcitonin level and the amount of bacteria in acute bacterial rhinosinusitis mice model. &amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt;Experimental research with posttest only control group design in 32 Wistar mice that were divided into 4 groups, 3 of which were being inoculated with Staphylococcus aureus by inserting a sponge to right nasal cavity of the mice (group K2, K3, and K4); another one was the negative control group (K1). Group K2 was not given any kind of therapy (positive control), group K3 was given 10 mg\/kd EEPL for 5 days orally during an induction, and group K4 was given 10 mg\/kd EEPL for 5 days orally on the 10th day after induction. Mice in the groups K2 and K3 were sacrificed on the 10th day after induction, while mice in group K4 were sacrificed on the 15th day after induction. &amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Result&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt;A statistically significant decrease in procalcitonin level (p&amp;amp;lt;0.001) and amount of bacterial colony (p&amp;amp;lt;0.001) was found in four groups.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt; Conclusion&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; Poguntano leaves extract can lower procalcitonin and amount of bacteria colony, showing an anti-inflammatory and antibacterial effect.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1091-20","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T10:28:16Z","timestamp":1713695296000},"page":"110-116","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Poguntano leaves extract (Picria fel-terrae Merr.) to procalcitonin level in acute bacterial rhinosinusitis model of Wistar mice"],"prefix":"10.17392","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1599-8307","authenticated-orcid":false,"given":"Andrina Yunita","family":"Murni Rambe","sequence":"first","affiliation":[{"name":"School of Medicine, Universitas Sumatera Utara","place":["Medan,Indonesia"],"department":["Department of Otolaryngology, Head and Neck Surgery"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delfitri","family":"Munir","sequence":"additional","affiliation":[{"name":"Universitas Sumatera Utara","place":["Medan,Indonesia"],"department":["Department of Otolaryngology, Head and Neck Surgery"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosita Juwita","family":"Sembiring","sequence":"additional","affiliation":[{"name":"Universitas Sumatera Utara","department":["Department of Clinical Pathology, School of Medicine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syafruddin","family":"Ilyas","sequence":"additional","affiliation":[{"name":"Universitas Sumatera Utara","department":["Department of Biology"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49509","published-online":{"date-parts":[[2019,9,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD000243.pub3","article-title":"Antibiotics for acute maxillary sinusitis in adults","author":"AAhovuo-SalorantaA","year":"2014","unstructured":"Ahovuo-Saloranta A, Rautakorpi UM, Borisenko \nOV, Liira H, Williams Jr JW, M\u00e4kel\u00e4 M. Antibiotics \nfor acute maxillary sinusitis in adults. Cochrane Da-\ntabase Syst Rev 2014; CD000243.","journal-title":"Cochrane Database Syst Rev"},{"key":"ref2","first-page":"479","article-title":"Low-value care for acute sinusitis encounters : Who's choosing wisely?","author":"ASharpA","year":"2015","unstructured":"Sharp AL, Klau MH, Keschner D, Macy E, Tang \nT, Shen E, Munoz-Plaza C, Kanter M, Silver MA, \nGould MK. Low-value care for acute sinusitis enco-\nunters : Who's choosing wisely?. Am J Manag Care \n2015; 21:479-85.","journal-title":"Am J Manag Care"},{"key":"ref3","first-page":"5703","article-title":"Avoid prescribing antibiotics in acute rhinosinusitis","author":"WFokkensW","year":"2014","unstructured":"Fokkens WJ, Hoffmans R, Thomas M. Avoid pres-\ncribing antibiotics in acute rhinosinusitis. 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Lancet 2008; 371:908-14.","journal-title":"Lancet"},{"key":"ref8","first-page":"6245","article-title":"Continued high rates of antibiotic prescribing to adults with respiratory tract infection: survey of 568 UK general practices","author":"MGullifordM","year":"2014","unstructured":"Gulliford MC, Dregan A, Moore MV, Ashworth M, \nVan Staa T, McCann G, Charlton J, Yardley L, Little \nP, McDermott L. Continued high rates of antibiotic \nprescribing to adults with respiratory tract infecti-\non: survey of 568 UK general practices. BMJ Open \n2014; 4:e006245.","journal-title":"BMJ Open"},{"key":"ref9","article-title":"Antibiotics for clinically diagnosed acute rhinosinusitis in adults","author":"MLemiengreM","year":"2012","unstructured":"Lemiengre MB, Van Driel ML, Merenstein D, Yo-\nung, J, De Sutter AI. Antibiotics for clinically dia-\ngnosed acute rhinosinusitis in adults. Cochrane Da-\ntabase Syst Rev 2012; 10:CD006089.","journal-title":"Cochrane Database Syst Rev"},{"key":"ref10","first-page":"55","article-title":"Longitudinal analysis of inflammatory biomarkers during acute rhinosinusitis","author":"TAutioT","year":"2017","unstructured":"Autio TJ, Koskenkorva T, Leino TK, Koivunen P, \nAlho OP. Longitudinal analysis of inflammatory bi-\nomarkers during acute rhinosinusitis. The Laryngos-\ncope 2017; 127:E55-61.","journal-title":"The Laryngoscope"},{"key":"ref11","first-page":"717","article-title":"Clinical outcomes associated with procalcitonin algorithms to guide antibiotic therapy in respiratory tract infections","author":"PSchuetzP","year":"2013","unstructured":"Schuetz P, Briel M, Mueller B. Clinical outcomes \nassociated with procalcitonin algorithms to guide \nantibiotic therapy in respiratory tract infections. \nJAMA 2013; 309:717-8.","journal-title":"JAMA"},{"key":"ref12","first-page":"282","article-title":"C-reactive protein and serum procalcitonin levels as markers of bacterial upper respiratory tract infections","author":"DKofteridisD","year":"2009","unstructured":"Kofteridis DP, Samonis G, Karatzanis AD, Fra-\ngiadakis GM, Bourolias C A, Maraki S, Papadakis \nJA, Velegrakis GA. C-reactive protein and serum \nprocalcitonin levels as markers of bacterial upper \nrespiratory tract infections. Am J Infect Dis 2009; \n5:282-7.","journal-title":"Am J Infect Dis"},{"key":"ref13","article-title":"Further studies of the phase 1 clinical trials in humans can be conducted to determine whether it may be represent novel therapy for acute rhinosinusitis in humans. FUNDING No specific funding was received for this study","unstructured":"therapy in acute rhinosinusitis. Further studies of \nthe phase 1 clinical trials in humans can be con-\nducted to determine whether it may be represent \nnovel therapy for acute rhinosinusitis in humans. \nFUNDING \nNo specific funding was received for this study. \nTRANSPARENCY DECLARATION \nConflicts of interest: None to declare."},{"key":"ref14","first-page":"1","article-title":"Serum PCT and CRP levels in upper respiratory tract infections as a marker of infection","author":"PChauhanP","year":"2013","unstructured":"Chauhan P, Sood A, Jain M, Dabla P, Sood S. Serum \nPCT and CRP levels in upper respiratory tract infec-\ntions as a marker of infection. AIJCR 2013; 6:1-4.","journal-title":"AIJCR"},{"key":"ref15","first-page":"165","article-title":"A systematic review of phytotherapy for acute rhinosinusitis","author":"AKochA","year":"2016","unstructured":"Koch AK, Klose P, Lauche R, Cramer H, Baasch \nJ, Dobos GJ, Langhorst J. A systematic review of \nphytotherapy for acute rhinosinusitis. 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Inhibitory effects of flavonoids on TNF-\n\u03b1-induced IL-8 gene expression in HEK 293 cells. \nBMB Rep 2008; 265-70.","journal-title":"BMB Rep"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"31318","DOI":"10.1371\/journal.pone.0031318","article-title":"Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-\u03baB, AP-1 and NF-AT","author":"RCheckerR","year":"2012","unstructured":"Checker R, Sandur SK, Sharma D, Patwardhan RS, \nJayakumar S, Kohli V, Sethi G, Aggarwal BB, Sai-\nnis KB. Potent anti-inflammatory activity of ursolic \nacid, a triterpenoid antioxidant, is mediated through \nsuppression of NF-\u03baB, AP-1 and NF-AT. PLoS One \n2012; 7:E31318.","journal-title":"PLoS One"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"70","DOI":"10.7324\/JAPS.2016.600112","article-title":"Triterpenoid fraction isolated from Euphorbia tirucalli Linn. amelorates collagen induced arthritis in Wistar rats","author":"PChandrasenanP","year":"2016","unstructured":"Chandrasenan P, Neethu MV, Anjumol VM, Anan-\ndan V, Selvaraj R. Triterpenoid fraction isolated \nfrom Euphorbia tirucalli Linn. amelorates collagen \ninduced arthritis in Wistar rats. J App Pharm Sci \n2016; 6:070-5.","journal-title":"J App Pharm Sci"},{"key":"ref22","first-page":"1","article-title":"Comparative study between Federer and Gomez method for number of replication in complete randomized design using simulation: study of Areca Palm (Areca catechu) as organic waste for producing handicraft paper","author":"AIhwahA","year":"2018","unstructured":"Ihwah A, Deoranto P, Wijana S, Dewi IA. 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