{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:28:48Z","timestamp":1792196928819,"version":"4.4.0"},"reference-count":37,"publisher":"Medical Association of Zenica-Doboj","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2020,7,12]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim &amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt;ABO blood group genotypes are established as a genetic factor in pathophysiology of various diseases, such as cardiovascular disorders, cancers, infectious diseases and there is rising evidence of their involvement in other conditions. The aim of this study was to determine if ventilatory changes of lung function in asthma, measured by biomarkers\/parameters, are connected to certain ABO blood group genotypes in Croatia. &amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; A case-control study included 149 patients with asthma and 153 healthy individuals (blood donors). ABO genotyping on five main alleles was performed using PCR-SSP method. All patients had spirometry performed and severity of asthma was estimated. Clinical parameters of spirometry (FEV 1 , FEV\/FVC, PEF), biomarkers FeNO, IgE and pO2 were measured. The &amp;amp;chi; 2 test, Fisher&amp;#039;s test, Kruskal-Wallis test and Spearman&amp;#039;s correlation coefficients with p\u02c20.05 were used as statistically significant. &amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Results&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt;There was no determined statistically significant difference in both ABO genotypes and phenotypes between patient and control groups. Comparison of the lung function in different ABO phenotypes in asthmatic patients also did not show any statistically significant differences in FEV1 values, FEV\/FVC ratio or PEF. Statistically significant differences in oxygenation between different ABO blood types have not been noticed (p=0.326). Differences in quantitative values of biomarkers (FeNO and IgE) between different ABO blood phenotypes in patients with asthma were not significant, except for IgE that had marginal values (p=0.074). &amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusion&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; No correlation was found between certain ABO blood group genotypes and parameters\/biomarkers of ventilatory dysfunction in patients with allergic and nonallergic asthma.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1099-20","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T10:28:16Z","timestamp":1713695296000},"page":"369-374","source":"Crossref","is-referenced-by-count":2,"title":["ABO blood group genotypes and ventilatory dysfunction in patients with allergic and nonallergic asthma"],"prefix":"10.17392","volume":"17","author":[{"given":"Marina","family":"Lampalo","sequence":"first","affiliation":[{"name":"University Hospital Centre","place":["Zagreb,Croatia"],"department":["Clinical Department for Lung Diseases Jordanovac"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irena","family":"Juki\u0107","sequence":"additional","affiliation":[{"name":"Croatian Institute of Transfusion Medicine (CITM)","place":["Zagreb,Croatia"],"department":["Medical Department"]},{"name":"Josip Juraj Strossmayer University","place":["Osijek,Croatia"],"department":["School of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasna","family":"Bingulac-Popovi\u0107","sequence":"additional","affiliation":[{"name":"Molecular Diagnostics Department, CITM","place":["Zagreb,Croatia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Safi\u0107 Stani\u0107","sequence":"additional","affiliation":[{"name":"Molecular Diagnostics Department, CITM","place":["Zagreb,Croatia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Ferara","sequence":"additional","affiliation":[{"name":"University of Zagreb","place":["Zagreb,Croatia"],"department":["School of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Popovi\u0107-Grle","sequence":"additional","affiliation":[{"name":"University Hospital Centre Zagreb","place":["Zagreb,Croatia"],"department":["Clinical Department for Lung Diseases Jordanovac"]},{"name":"University of Zagreb","place":["Zagreb,Croatia"],"department":["School of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"49509","published-online":{"date-parts":[[2020,7,12]]},"reference":[{"key":"ref1","first-page":"244","article-title":"Karl Landsteiner (1868-1943) and the discovery of blood groups","author":"JAymardJ","year":"2012","unstructured":"Aymard JP. Karl Landsteiner (1868-1943) and the \ndiscovery of blood groups. Transfus Clin Biol 2012; \n19:244-8.","journal-title":"Transfus Clin Biol"},{"key":"ref2","first-page":"1","article-title":"Molecular genetics of the ABO histoblood group system","author":"FYamamotoF","year":"1995","unstructured":"Yamamoto F. Molecular genetics of the ABO histo-\nblood group system. Vox Sang 1995; 69:1.","journal-title":"Vox Sang"},{"key":"ref3","first-page":"3035","article-title":"The nature of diversity and diversification at the ABO locus","author":"ASeltsamA","year":"2003","unstructured":"Seltsam A, Hallensleben, Kollomann A, Blasczyk \nR. The nature of diversity and diversification at the \nABO locus. Blood 2003; 102:3035-42.","journal-title":"Blood"},{"key":"ref4","first-page":"113","article-title":"Relationship of blood groups to disease: do blood group antigens have a biological role? Revista","author":"GGarrattyG","year":"2005","unstructured":"Garratty G. Relationship of blood groups to disease: \ndo blood group antigens have a biological role? Re-\nvista Medica del Instituto Mexicano Seguro Social \n2005; 43:113-21.","journal-title":"Medica del Instituto Mexicano Seguro Social"},{"key":"ref5","first-page":"491","article-title":"Beyond immunohaematology: the role of the ABO blood group in human diseases","author":"GLiumbrunoG","year":"2013","unstructured":"Liumbruno GM, Franchini M. Beyond immunohae-\nmatology: the role of the ABO blood group in human \ndiseases. Blood Transfus 2013; 11:491-9.","journal-title":"Blood Transfus"},{"key":"ref6","first-page":"434","article-title":"The prognostic value of ABO blood group in cancer patients","author":"MFranchiniM","year":"2016","unstructured":"Franchini M, Liumbruno GM, Lippi G. The progno-\nstic value of ABO blood group in cancer patients. \nBlood Transfus 2016; 14:434-40.","journal-title":"Blood Transfus"},{"key":"ref7","first-page":"107","article-title":"The role of the histoblood ABO group in cancer","author":"SRummelS","year":"2016","unstructured":"Rummel SK, Ellsworth RE. The role of the histo-\nblood ABO group in cancer. Future Sci OA 2016; \n2:FSO107.","journal-title":"Future Sci OA"},{"key":"ref8","first-page":"247","article-title":"Antigen structure and a genetic basis of histo blood groups A, B and O: their changes associated with human cancer","author":"SHakomoriS","year":"1999","unstructured":"Hakomori S. Antigen structure and a genetic basis of \nhisto blood groups A, B and O: their changes asso-\nciated with human cancer. Biochim Biophys Acta \n1999; 1473:247-66.","journal-title":"Biochim Biophys Acta"},{"key":"ref9","first-page":"550","article-title":"ABO blood groups and genetic risk factors for thrombosis in Croatian population","author":"IJukicI","year":"2009","unstructured":"Jukic I, Bingulac-Popovic J, Dogic V, Babic I, Culej \nJ, Tomicic M, Vuk T, Sarlija D, Balija M. ABO blo-\nod groups and genetic risk factors for thrombosis in \nCroatian population. Croat Med J 2009; 50:550-8.","journal-title":"Croat Med J"},{"key":"ref10","first-page":"525","article-title":"The Role of ABO Blood Type in Thrombosis Scoring Systems","author":"MFranchiniM","year":"2017","unstructured":"Franchini M, Marano G, Vaglio S, Catalano L, Pupe-\nlla S, Liumbruno GM. The Role of ABO Blood Type \nin Thrombosis Scoring Systems. Semin Thromb He-\nmost 2017; 43:525-9."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"444","DOI":"10.5581\/1516-8484.20110120","article-title":"Evidence of an association between the O blood group and allergic rhinitis","author":"NFalsarellaN","year":"2011","unstructured":"Falsarella N, Ferreira AI, Nakashima F, de Mattos \nCde C, de Mattos LC. Evidence of an association \nbetween the O blood group and allergic rhinitis. Rev \nBras Hematol Hemoter 2011; 33:444-8.","journal-title":"Rev Bras Hematol Hemoter"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"406","DOI":"10.5581\/1516-8484.20110113","article-title":"Allergic rhinitis and association with the O blood group","author":"CCarpeggianiC","year":"2011","unstructured":"Carpeggiani C. Allergic rhinitis and association \nwith the O blood group. Rev Bras Hematol Hemoter \n2011; 33:406-7.","journal-title":"Rev Bras Hematol Hemoter"},{"key":"ref13","first-page":"76","article-title":"Associations of blood group-related antigens to FEV1, wheezing, and asthma","author":"FKauffmannF","year":"1996","unstructured":"Kauffmann F, Frette C, Pham QT, Nafissi S, Ber-\ntrand JP, Oriol R. Associations of blood group-rela-\nted antigens to FEV1, wheezing, and asthma. Am J \nRespir Crit Care Med 1996; 153:76-82.","journal-title":"Am J Respir Crit Care Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00408-009-9175-1","article-title":"Lack of association between asthma and ABO blood group","author":"MBijanzadehM","year":"2009","unstructured":"Bijanzadeh M, Ramachandra NB, Mahesh PA, Sa-\nvitha MR, Manjunath BS, Jayaraj BS. Lack of asso-\nciation between asthma and ABO blood group. Lung \n2009; 187:389-92.","journal-title":"Lung"},{"key":"ref15","first-page":"242","article-title":"Association of ABO blood group polymorphism and tuberculosis: A study on Bengalee Hindu caste population","author":"SGangulyS","year":"2016","unstructured":"Ganguly S, Sarkar P, Chatterjee D, Bandyopadhyay \nAR. Association of ABO blood group polymorphi-\nsm and tuberculosis: A study on Bengalee Hindu ca-\nste population, West Bengal, India. Indian J Tuberc \n2016; 63:242-4.","journal-title":"Indian J Tuberc"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.31768\/2312-8852.2018.40(3):249-250","article-title":"ABO blood group and the risk of lung cancer in Greek adults: a case -control study","author":"NChrysanthakopoulosN","year":"2018","unstructured":"Chrysanthakopoulos NA, Dareioti NS. ABO blood \ngroup and the risk of lung cancer in Greek adults: \na case -control study. Exp Oncol 2018; 40:249-50.","journal-title":"Exp Oncol"},{"key":"ref17","first-page":"65","article-title":"Current Clinical Practice: Bronchial Asthma: a Guide for Practical Understanding and Treatment","author":"CChangC","year":"2006","unstructured":"Chang C. Treatment of asthma in children. In: \nGershwin ME, Albertson TE, eds. Current Clinical \nPractice: Bronchial Asthma: a Guide for Practical \nUnderstanding and Treatment. New Jersey: Humana \nPress Inc., 2006: 65-111."},{"key":"ref18","first-page":"758","article-title":"Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC)","author":"NPearceN","year":"2007","unstructured":"Pearce N, A\u00eft-Khaled N, Beasley R, Mallol J, Keil \nU, Mitchell E, Robertson C; ISAAC Phase Three \nStudy Group. Worldwide trends in the prevalence of \nasthma symptoms: phase III of the International Stu-\ndy of Asthma and Allergies in Childhood (ISAAC). \nThorax 2007; 62:758-66.","journal-title":"Thorax"},{"key":"ref19","article-title":"The global burden of asthma report. Global initiative for asthma (GINA)","year":"09 January 2020","unstructured":"The global burden of asthma report. Global initiative \nfor asthma (GINA). http:\/\/www.ginaasthma.org (09 \nJanuary 2020)."},{"key":"ref20","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nature00878","article-title":"Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness","author":"PVan EerdeweghP","year":"2002","unstructured":"Van Eerdewegh P, Little RD, Dupuis J, Del Mastro \nRG, Falls K, Simon J, Torrey D, Pandit S, McKenny \nJ, Braunschweiger K, Walsh A, Liu Z, Hayward B, \nFolz C, Manning SP, Bawa A, Saracino L, Thackston \nM, Benchekroun Y, Capparell N, Wang M, Adair R, \nFeng Y, Dubois J, FitzGerald MG, Huang H, Gib-\nson R, Allen KM, Pedan A, Danzig MR, Umland SP, \nEgan RW, Cuss FM, Rorke S, Clough JB, Holloway \nJW, Holgate ST, Keith TP. Association of the \nADAM33 gene with asthma and bronchial hyperres-\nponsiveness. Nature 2002; 418:426-30.","journal-title":"Nature"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2165\/00129785-200202030-00001","article-title":"Genetic analyses in asthma: current concepts and future directions","author":"HHakonarsonH","year":"2002","unstructured":"Hakonarson H, Halapi E. Genetic analyses in asth-\nma: current concepts and future directions. Am J \nPharmacogenomics 2002; 2:155-66.","journal-title":"Am J Pharmacogenomics"},{"key":"ref22","first-page":"149","article-title":"An understanding of the genetic basis of asthma","author":"MBijanzadehM","year":"2011","unstructured":"Bijanzadeh M, Mahesh PA, Ramachandra NB. An \nunderstanding of the genetic basis of asthma. Indian \nJ Med Res 2011; 134:149-61.","journal-title":"Indian J Med Res"},{"key":"ref23","first-page":"287","article-title":"House dust mite-specific immunotherapy alters the basal expression of T regulatory and FcERI pathway genes","author":"BPevecB","year":"2012","unstructured":"Pevec B, Radulovic Pevec M, Stipic Markovic A, \nBatista I, Rijavec M, Silar M, Kosnik M, Korosec P. \nHouse dust mite-specific immunotherapy alters the \nbasal expression of T regulatory and FcERI pathway \ngenes. Int Arch Allergy Immunol 2012; 159:287-96.","journal-title":"Int Arch Allergy Immunol"},{"key":"ref24","first-page":"271","article-title":"The impact of gender on asthma in the daily clinical practice","author":"GCiprandiG","year":"2018","unstructured":"Ciprandi G, Gallo F. The impact of gender on asth-\nma in the daily clinical practice. Postgrad Med 2018; \n130:271-3.","journal-title":"Postgrad Med"},{"key":"ref25","first-page":"1852","article-title":"ABO glycosyltransferase genotyping by polymerase chain reaction using sequence-specific primers","author":"CGassnerC","year":"1996","unstructured":"Gassner C, Schmard A, Nussbaumer W, Sch\u00f6nitzer \nD. ABO glycosyltransferase genotyping by polyme-\nrase chain reaction using sequence-specific primers. \nBlood 1996; 88:1852-6.","journal-title":"Blood"},{"key":"ref26","first-page":"305","article-title":"Genetic polymorphism of ABO and Rh system in relation to bronchial asthma: preliminary report","author":"ADe La VegaA","year":"1976","unstructured":"De la Vega AR, G\u00f3mez CJ, Bacallao GJ. Genetic \npolymorphism of ABO and Rh system in relation \nto bronchial asthma: preliminary report. Allergol \nImmunopathol (Madr) 1976; 4:305-10.","journal-title":"Allergol Immunopathol (Madr)"},{"key":"ref27","first-page":"37","article-title":"Nwanoke NN. Relationship between ABO and Rhesus blood groups and susceptibility to asthma within Sokoto metropolis","author":"MAloM","year":"2015","unstructured":"Alo MN, Eze UA, Abdulhi Yaro S, Jubril B, Nwano-\nke NN. Relationship between ABO and Rhesus blo-\nod groups and susceptibility to asthma within Soko-\nto metropolis, Nigeria. Int J Immunol 2015; 3:37-41.","journal-title":"Int J Immunol"},{"key":"ref28","first-page":"337","article-title":"Associations between atopic diseases and the polymorphic systems ABO, Kidd, Inv and red cell acid phosphatase","author":"RBrachtelR","year":"1979","unstructured":"Brachtel R, Walter H, Beck W, Hilling M. Associa-\ntions between atopic diseases and the polymorphic \nsystems ABO, Kidd, Inv and red cell acid phospha-\ntase. Hum Genet 1979; 49:337-48.","journal-title":"Hum Genet"},{"issue":"Suppl 3","key":"ref29","first-page":"1827","article-title":"The correlation of allergic rhinitis with ABO phenotype","author":"NTopnoN","year":"2019","unstructured":"Topno N, Narvey VP, Jain AK. The correlation of \nallergic rhinitis with ABO phenotype. Indian J Oto-\nlaryngol Head Neck Surg 2019; 71(Suppl 3):1827-\n31.","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"ref30","first-page":"1236","article-title":"ABO\/Secretor genetic complex and susceptibility to asthma in childhood","author":"FRonchettiF","year":"2001","unstructured":"Ronchetti F, Villa MP, Ronchetti R, Bonci E, Latini \nL, Pascone R, Bottini N, Gloria-Bottini F. ABO\/Se-\ncretor genetic complex and susceptibility to asthma \nin childhood. Eur Respir J 2001; 17:1236-8.","journal-title":"Eur Respir J"},{"key":"ref31","first-page":"1","article-title":"Asthma is associated with increased susceptibility to infection","author":"VPatellaV","year":"2015","unstructured":"Patella V, Bocchino M, Steinhilber G: Asthma is \nassociated with increased susceptibility to infection. \nMinerva Med 2015; 106:1-7.","journal-title":"Minerva Med"},{"key":"ref32","first-page":"1613","article-title":"Cooperative effect of adenosine deaminase and ABO-secretor genetic complex on susceptibility to childhood asthma","author":"NBottiniN","year":"2002","unstructured":"Bottini N, Ronchetti F, Gloria-Bottini F. Cooperative \neffect of adenosine deaminase and ABO-secretor ge-\nnetic complex on susceptibility to childhood asthma. \nEur Respir J 2002; 20:1613-5.","journal-title":"Eur Respir J"},{"key":"ref33","first-page":"458","article-title":"Predictive Genetic Testing -New Possibilities in Determination of Risk of Complex Diseases","author":"CQuinziiC","year":"2001","unstructured":"Quinzii C, Belpinati F, Pignatti PF. Predictive Ge-\nnetic Testing -New Possibilities in Determination \nof Risk of Complex Diseases. Croat Med J 2001; \n42:458-62.","journal-title":"Croat Med J"},{"key":"ref34","first-page":"1","article-title":"Applications of molecular genetics to the study of asthma","author":"CSanz-LozanoC","year":"2016","unstructured":"Sanz-Lozano CS, Garc\u00eda-Solaesa V, Davila I, Isi-\ndoro-Garc\u00eda M. Applications of molecular genetics \nto the study of asthma. Methods Mol Biol 2016; \n1434:1-13.","journal-title":"Methods Mol Biol"},{"key":"ref35","first-page":"926","article-title":"ABO\/secretor genetic complex is associated with the susceptibility of childhood asthma in Taiwan","author":"YChenY","year":"2005","unstructured":"Chen YL, Chen JC, Lin TM, Huang TJ, Wang ST, \nLee MF, Wang JY. ABO\/secretor genetic complex is \nassociated with the susceptibility of childhood asth-\nma in Taiwan. Clin Exp Allergy 2005; 35:926-32.","journal-title":"Clin Exp Allergy"},{"key":"ref36","first-page":"73","article-title":"ABO histo-blood group and risk of respiratory atopy in children: a review of published evidence","author":"SUwaezuokeS","year":"2018","unstructured":"Uwaezuoke SN, Eze JN, Ayuk AC, Ndu IK. ABO \nhisto-blood group and risk of respiratory atopy in \nchildren: a review of published evidence. Pediatric \nHealth Med Ther 2018; 9:73-9.","journal-title":"Pediatric Health Med Ther"},{"key":"ref37","first-page":"29559","article-title":"Association of ABO blood groups with allergic diseases: a scoping review","author":"NDahalanN","year":"2020","unstructured":"Dahalan NH, Tuan Din SA, Mohamad SMB. Asso-\nciation of ABO blood groups with allergic diseases: \na scoping review. BMJ Open 2020; 10:e029559.","journal-title":"BMJ Open"}],"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/337\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/337\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:44:54Z","timestamp":1775468694000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/386\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,12]]},"references-count":37,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,7,12]]},"published-print":{"date-parts":[[2020,7,12]]}},"URL":"https:\/\/doi.org\/10.17392\/1099-20","archive":["Internet Archive"],"relation":{},"ISSN":["1840-0132","1840-0132"],"issn-type":[{"value":"1840-0132","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7,12]]}}}