{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T15:53:57Z","timestamp":1775577237182,"version":"3.50.1"},"reference-count":22,"publisher":"Medical Association of Zenica-Doboj","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2019,9,22]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;Rheumatic heart disease (RHD) is influenced by genetic factor, microorganism&amp;#039;s virulence, and environmental factor. The aim of this study was to determine human leukocyte (HLA)-DRB1 allele among children with RHD in Medan, Indonesia. &amp;lt;strong&amp;gt;Methods &amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt;An observational study was conducted at the Department of Child Health, Haji Adam Malik Hospital Medan from April to June 2017. Inclusion criteria were children aged 5-18 years diagnosed with RHD. Children with concomitant congenital heart disease were excluded. HLA-DRB1 alleles were analyzed using the PCR sequence-specific priming (SSP) technique. Statistical analysis was done using computer software. &amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Results&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt;A total of 62 children were enrolled. The mean age of children was 12.6 (SD 3.44) years; 33 (53.2%) were male. The most dominant allele was HLA-DRB1*12, followed by HLA-DRB1*15. &amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusion&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; It is proven in this research that RHD is influenced by genetic factor with HLA-DRB1*12 allele found to be the most common allele in children with RHD in Medan, Indonesia.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1101-20","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T10:28:16Z","timestamp":1713695296000},"page":"106-109","source":"Crossref","is-referenced-by-count":1,"title":["HLA-DRB1 allele distribution among children with rheumatic heart disease in Haji Adam Malik Hospital Medan, Indonesia"],"prefix":"10.17392","volume":"17","author":[{"given":"Tina Christina","family":"Lumban Tobing","sequence":"first","affiliation":[{"name":"Universitas Sumatera Utara","place":["Medan,Indonesia"],"department":["Department of Child Health, School of Medicine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teddy","family":"Ontoseno","sequence":"additional","affiliation":[{"name":"Universitas Airlangga","department":["Department of Child Health, School of Medicine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sri Endah","family":"Rahayuningsih","sequence":"additional","affiliation":[{"name":"Universitas Padjajaran","department":["Department of Child Health, School of Medicine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ratna","family":"Akbari Ganie","sequence":"additional","affiliation":[{"name":"Universitas Sumatera Utara","department":["Department of Clinical Pathology"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yahwardiah","family":"Siregar","sequence":"additional","affiliation":[{"name":"Universitas Sumatera Utara","department":["Department of Biochemistry, School of Medicine"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49509","published-online":{"date-parts":[[2019,9,22]]},"reference":[{"key":"ref1","first-page":"153","article-title":"Paediatric Cardiology for Practitioners: Acute Rheumatic Fever","author":"MParkM","year":"2008","unstructured":"Park, MK. 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