{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:57:45Z","timestamp":1775473065121,"version":"3.50.1"},"reference-count":28,"publisher":"Medical Association of Zenica-Doboj","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2020,7,12]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; To investigate the effects of interleukin-8 (IL-8)-251 T\/A and +781 C\/T polymorphism on the risk of Helicobacter pyloriinfection gastritis in children, and the IL-8 level of children with or without gastritis H. pylori infection according to polymorphism. &amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; This prospective, case control clinical study included 64 children 2-18 years old. A disease group (32 gastritis patients with H. pylori-infection) was compared with a control group (32 gastritis patients without H. pylori infection). Demographic characteristics of patients were taken by a questionnaire; gastritis was confirmed by gastroscopy, H. pylori infection was confirmed with rapid urease test. Serum IL-8 level was measured by ELISA, and IL-8-251 T\/A and +781 C\/T polymorphisms were analysed by RT-PCR. Demographic characteristics, IL-8 level, polymorphism of patients, and IL-8 level according to polymorphisms were compared between the groups. &amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Results&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; Children with tobacco exposure were associated with an increased risk of H. pylori-infection gastritis by 3.4-fold. There was a higher IL-8 level in the disease group compared to the control group. The disease group with IL-8-251 AT polymorphism had a higher risk compared to TT polymorphism by 8.7-fold, and with IL-8 +781 CT polymorphism had a higher risk compared to CC polymorphism by 10.7-fold. Children in the disease group with IL-8-251 AT and TT, and +781 CT and CC polymorphisms produced a higher IL-8 level than the control group in respective polymorphisms. &amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusion&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt; Children with H. pylori-infection gastritis have higher IL-8 production. There was an increased risk of developing H. pylori-infection in heterozygous-251 AT and +781 CT.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1160-20","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T10:28:16Z","timestamp":1713695296000},"page":"383-388","source":"Crossref","is-referenced-by-count":1,"title":["Interleukin-8 heterozygous polymorphism (-251 T\/A and +781 C\/T) increases the risk of Helicobacter pylori-infection gastritis in children: a case control study"],"prefix":"10.17392","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5681-9777","authenticated-orcid":false,"given":"Dr","family":"Supriatmo","sequence":"first","affiliation":[{"name":"School of Medicine, Universitas Sumatera Utara","place":["Medan,Indonesia"],"department":["Department of Child Health"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gontar","family":"Alamsyah Siregar","sequence":"additional","affiliation":[{"name":"School of Medicine, Universitas Sumatera Utara","place":["Medan,Indonesia"],"department":["Department of Internal Medicine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iqbal","family":"Pahlevi Adeputra Nasution","sequence":"additional","affiliation":[{"name":"School of Medicine, Universitas Sumatera Utara","place":["Medan,Indonesia"],"department":["Department of Surgery"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oke Rina","family":"Ramayani","sequence":"additional","affiliation":[{"name":"School of Medicine, Universitas Sumatera Utara","place":["Medan,Indonesia"],"department":["Department of Child Health"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49509","published-online":{"date-parts":[[2020,7,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/978-3-030-15573-5_6","article-title":"Surgical Pathology of Non-neoplastic Gastrointestinal Diseases","author":"MTorbensonM","year":"2019. 28 Feb 2020","unstructured":"Torbenson M. 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Cancer Causes Control 2006; \n17:117-25.","journal-title":"Cancer Causes Control"}],"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/1837\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/1837\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:44:22Z","timestamp":1775468662000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/255\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,12]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,7,12]]},"published-print":{"date-parts":[[2020,7,12]]}},"URL":"https:\/\/doi.org\/10.17392\/1160-20","archive":["Internet Archive"],"relation":{},"ISSN":["1840-0132","1840-0132"],"issn-type":[{"value":"1840-0132","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7,12]]}}}