{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:58:08Z","timestamp":1775473088652,"version":"3.50.1"},"reference-count":49,"publisher":"Medical Association of Zenica-Doboj","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2020,10,9]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim &amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt;To assess the impact of semi-refined carrageenan (E407a) on hydrophobic regions of phosphololipid bilayer in cell membranes of leukocytes collected from rats orally administered this food additive and white blood cells incubated with E407a.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;Fluorescent probes (ortho-hydroxy derivatives of 2,5-diaryl-1,3-oxazole) were used to estimate the state of lipid bilayer in leukocytes obtained from rats orally exposed to the food additive E407a and in white blood cells incubated with E407a.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Results &amp;lt;\/strong&amp;gt;&amp;lt;br \/&amp;gt;No noticeable changes in the physico-chemical properties were observed in the lipid membranes of leukocytes in the region where the probes locate in response to oral intake of semi-refined carrageenan. Incubation of leukocytes with E407a solutions resulted in a decrease in polarity and proton-donor ability of leukocytes in the area of carbonyl groups of phospholipids and in the area of hydrocarbon chains of phospholipids near the polar region of the bilayer.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusion&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;Membrane fluidity abnormalities found in cells exposed to E407a are similar to those observed in patients with IBD&amp;lt;br \/&amp;gt;suggesting that contribution of carrageenan to IBD development may be partially explained by leukocyte membrane modifications.&amp;amp;nbsp;&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1213-21","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T10:28:16Z","timestamp":1713695296000},"page":"176-183","source":"Crossref","is-referenced-by-count":3,"title":["Effects of semi-refined carrageenan (food additive E407a) on cell membranes of leukocytes assessed in vivo and in vitro"],"prefix":"10.17392","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1029-1636","authenticated-orcid":false,"given":"Anton","family":"Tkachenko","sequence":"first","affiliation":[{"name":"Kharkiv National Medical University","place":["Kharkiv,Ukraine"],"department":["Department of Biochemistry"]},{"name":"Kharkiv National Medical University","place":["Kharkiv,Ukraine"],"department":["Department of Epidemiology"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anatolii","family":"Onishchenko","sequence":"additional","affiliation":[{"name":"Kharkiv National Medical University","place":["Kharkiv,Ukraine"],"department":["Department of Biochemistry"]},{"name":"Kharkiv National Medical University","place":["Kharkiv,Ukraine"],"department":["Department of Epidemiology"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Roshal","sequence":"additional","affiliation":[{"name":"Karazin Kharkiv National University","place":["Kharkiv ,Ukraine"],"department":["Institute of Chemistry, V.N."]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana","family":"Nakonechna","sequence":"additional","affiliation":[{"name":"Kharkiv National Medical University","place":["Kharkiv,Ukraine"],"department":["Department of Biochemistry"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetyana","family":"Chumachenko","sequence":"additional","affiliation":[{"name":"Kharkiv National Medical University","place":["Kharkiv,Ukraine"],"department":["Department of Epidemiology"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yevgen","family":"Posokhov","sequence":"additional","affiliation":[{"name":"The National Technical University \u201cKharkiv Polytechnic Institute\u201d","place":["Kharkiv,Ukraine"],"department":["Department of Organic Chemistry, Biochemistry and Microbiology"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49509","published-online":{"date-parts":[[2020,10,9]]},"reference":[{"key":"ref1","first-page":"398","article-title":"Diet as a trigger or therapy for inflammatory bowel diseases","author":"JLewisJ","year":"2017","unstructured":"Lewis JD, Abreu MT. 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