{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:57:37Z","timestamp":1775473057518,"version":"3.50.1"},"reference-count":40,"publisher":"Medical Association of Zenica-Doboj","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2020,10,9]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim &amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt;To assess concordance of eight frequently used serology-based scoring indices for liver fibrosis and cirrhosis with transient elastography (TE) in chronic hepatitis C (CHC) patients in order to determine serum indices with the highest concordance and clinical usability in clinical practice.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods &amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt;In this prospective study, 63 CHC patients were included and TE results were compared with eight non-invasive indices.&amp;lt;br \/&amp;gt;The diagnostic performance of these tests was assessed using receiver operating characteristic curves with kappa index calculated for the concordance analysis.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Results&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;Median age of 63 patients was 54 years (interquartile range: 42 to 63); 27 (42.9%) were females. According to areas under the Receiver Operating Characteristics (AUROC), the best performing serum markers for significant liver fibrosis (METAVIR &amp;amp;ge;F2), advanced liver fibrosis (&amp;amp;ge;F3) and cirrhosis (F4) determined by TE measurements (&amp;amp;ge;7.1kPa, &amp;amp;ge;9.5kPa and &amp;amp;ge;12kPa, respectively) were Fibrotest (AUROC=0.727 for &amp;amp;ge;F2) and FIB-4 score (AUROC=0.779 for &amp;amp;ge;F3 and AUROC=0.889 for F4). Fibrotest cut-off at &amp;amp;gt;0.50 was concordant with TE for presence of significant fibrosis in 30 (out of 45; 66.7%), FIB-4 cut-off at &amp;amp;lt;1.45 was concordant for absence of significant fibrosis in 13 (out of 18; 72.2%) and&amp;lt;br \/&amp;gt;Goeteborg University Cirrhosis Index (GUCI) cut-off at &amp;amp;gt;1 was concordant for presence of cirrhosis in 16 (out of 22; 72.7%) patients, but not for exclusion of cirrhosis.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusion&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;Serology-based scoring indices had moderate overall concordance with TE. We propose that FIB-4 score, Fibrotest and&amp;lt;br \/&amp;gt;GUCI be used in routine practice to exclude and diagnose significant fibrosis and diagnose cirrhosis, respectively.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1269-21","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T10:28:16Z","timestamp":1713695296000},"page":"70-76","source":"Crossref","is-referenced-by-count":0,"title":["Concordance of non-invasive serology-based scoring indices and transient elastography for liver fibrosis and cirrhosis in chronic hepatitis C"],"prefix":"10.17392","volume":"18","author":[{"given":"Emir","family":"Trna\u010devi\u0107","sequence":"first","affiliation":[{"name":"University Clinical Centre Tuzla","place":["Tuzla,Bosnia and Herzegovina"],"department":["Department for Laboratory Diagnostics"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4727-9267","authenticated-orcid":false,"given":"Nermin","family":"Salki\u0107","sequence":"additional","affiliation":[{"name":"University Clinical Centre Tuzla","place":["Tuzla,Bosnia and Herzegovina"],"department":["Department of Gastroenterology and Hepatology, Internal Medicine Hospital"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alma","family":"Trna\u010devi\u0107","sequence":"additional","affiliation":[{"name":"University Clinical Centre Tuzla","place":["Tuzla,Bosnia and Herzegovina"],"department":["Infectious Disease Hospital"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Divkovi\u0107","sequence":"additional","affiliation":[{"name":"University Clinical Centre Tuzla","place":["Tuzla,Bosnia and Herzegovina"],"department":["Department for Laboratory Diagnostics"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Huki\u0107","sequence":"additional","affiliation":[{"name":"University Clinical Centre Tuzla","place":["Tuzla,Bosnia and Herzegovina"],"department":["Department for Laboratory Diagnostics"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nusret","family":"Butkovi\u0107","sequence":"additional","affiliation":[{"name":"University Clinical Centre Tuzla","place":["Tuzla,Bosnia and Herzegovina"],"department":["Department for Laboratory Diagnostics"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amra","family":"Serak","sequence":"additional","affiliation":[{"name":"Public Health Centre Tuzla","place":["Tuzla,Bosnia and Herzegovina"],"department":["Department of Family Medicine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amer","family":"Mujkanovi\u0107","sequence":"additional","affiliation":[{"name":"University Clinical Centre Tuzla, Surgery Hospital","place":["Tuzla,Bosnia and Herzegovina"],"department":["Department for Plastic Surgery"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49509","published-online":{"date-parts":[[2020,10,9]]},"reference":[{"key":"ref1","first-page":"718","article-title":"EASL HEPAHE-ALTH Steering Committee. 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Antiviral Res 2018; 150:9-14.","journal-title":"Antiviral Res"},{"key":"ref4","first-page":"477","article-title":"Practices of liver liopsy in France: results of a prospective nationwide survey","author":"J-FCadranelJ-F","year":"2000","unstructured":"Cadranel J-F, Rufat P, Degos F. Practices of liver li-\nopsy in France: results of a prospective nationwide \nsurvey. Hepatology 2000; 32:477-81.","journal-title":"Hepatology"},{"key":"ref5","first-page":"2614","article-title":"Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection","author":"ARegevA","year":"2002","unstructured":"Regev A, Berho M, Jeffers LJ, Milikowski C, Molina \nEG, Pyrsopoulos NT, Feng Z-Z, Reddy KR, Schiff \nER. 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He-\npatology 2005 19; 41:257-64.","journal-title":"Hepatology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/S0140-6736(00)04258-6","article-title":"Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study","author":"FImbert-BismutF","year":"2001","unstructured":"Imbert-Bismut F, Ratziu V, Pieroni L, Charlotte F, Be-\nnhamou Y, Poynard T. Biochemical markers of liver \nfibrosis in patients with hepatitis C virus infection: a \nprospective study. Lancet 2001; 357:1069-75.","journal-title":"Lancet"},{"key":"ref9","first-page":"518","article-title":"A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C","author":"CWaiC","year":"2003","unstructured":"Wai C. A simple noninvasive index can predict both \nsignificant fibrosis and cirrhosis in patients with chro-\nnic hepatitis C. 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Hepatology 2011; 53:726-36.","journal-title":"Hepatology"},{"key":"ref13","first-page":"282","article-title":"Predicting cirrhosis in patients with hepatitis C based on standard laboratory tests: Results of the HALT-C cohort","author":"AsfLokAsf","year":"2005","unstructured":"Lok ASF, Ghany MG, Goodman ZD, Wright EC, \nEverson GT, Sterling RK, Everhart JE, Lindsay KL, \nBonkovsky HL, Di Bisceglie AM, Lee WM, Morgan \nTR, Dienstag JL, Morishima C, HALT-C Trial Group. \nPredicting cirrhosis in patients with hepatitis C based \non standard laboratory tests: Results of the HALT-C \ncohort. Hepatology 2005; 42:282-92.","journal-title":"Hepatology"},{"key":"ref14","first-page":"867","article-title":"Cirrhosis in hepatitis C virus-infected patients can be excluded using an index of standard biochemical serum markers","author":"SIslamS","year":"2005","unstructured":"Islam S, Antonsson L, Westin J, Lagging M. Cirrhosis \nin hepatitis C virus-infected patients can be excluded \nusing an index of standard biochemical serum mar-\nkers. Scand J Gastroenterol 2005; 40:867-72.","journal-title":"Scand J Gastroenterol"},{"key":"ref15","first-page":"616","article-title":"Identification of chronic hepatitis B patients without significant liver fibrosis by a simple noninvasive predictive model","author":"AHuiA","year":"2005","unstructured":"Hui AY, Chan HL-Y, Wong VW-S, Liew C-T, Chim \nAM-L, Chan FK-L, Sung JJ-Y. Identification of chro-\nnic hepatitis B patients without significant liver fibro-\nsis by a simple noninvasive predictive model. Am J \nGastroenterol 2005; 100:616-23.","journal-title":"Am J Gastroenterol"},{"key":"ref16","first-page":"55","article-title":"Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: The ANRS HCEP-23 study","author":"J-PZarskiJ-P","year":"2012","unstructured":"Zarski J-P, Sturm N, Guechot J, Paris A, Zafrani E-S, \nAsselah T, Boisson R-C, Bosson J-L, Guyader D, \nRenversez J-C, Bronowicki J-P, Gelineau M-C, Tran \nA, Trocme C, Ledinghen VD, Lasnier E, Poujol-Ro-\nbert A, Ziegler F, Bourliere M, Voitot H, Larrey D, \nRosenthal-Allieri MA, Fouchard Hubert I, Bailly F, \nVaubourdolle M. Comparison of nine blood tests and \ntransient elastography for liver fibrosis in chronic he-\npatitis C: The ANRS HCEP-23 study. J Hepatol 2012; \n56:55-62.","journal-title":"J Hepatol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1053\/j.gastro.2008.01.034","article-title":"Performance of transient elastography for the staging of liver fibrosis: a meta-analysis","author":"MFriedrich-RustM","year":"2008","unstructured":"Friedrich-Rust M, Ong M, Martens S, Sarrazin C, \nBojunga J, Zeuzem S, Herrmann E. Performance of \ntransient elastography for the staging of liver fibrosis: \na meta-analysis. Gastroenterology 2008; 134:960-\n974.e8.","journal-title":"Gastroenterology"},{"key":"ref18","first-page":"237","article-title":"Clinical Practice Guidelines: non-invasive tests for evaluation of liver disease severity and prognosis","author":"Easl-Aleh","year":"2015","unstructured":"EASL-ALEH Clinical Practice Guidelines: non-inva-\nsive tests for evaluation of liver disease severity and \nprognosis. J Hepatol 2015; 63:237-64.","journal-title":"J Hepatol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"436","DOI":"10.4254\/wjh.v9.i8.436","article-title":"Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C","author":"DParanagu\u00e1-VezozzoD","year":"2017","unstructured":"Paranagu\u00e1-Vezozzo DC, Andrade A, Mazo DFC, \nNunes V, Guedes AL, Ragazzo TG, Moutinho R, \nNacif LS, Ono SK, Alves VAF, Carrilho FJ. Concor-\ndance of non-invasive mechanical and serum tests for \nliver fibrosis evaluation in chronic hepatitis C. World \nJ Hepatol 2017; 9:436.","journal-title":"World J Hepatol"},{"key":"ref20","first-page":"1368","article-title":"Diagnostic accuracy, reproducibility and robustness of fibrosis blood tests in chronic hepatitis C: a meta-analysis with individual data","author":"VLeroyV","year":"2008","unstructured":"Leroy V, Halfon P, Bacq Y, Boursier J, Rousselet \nMC, Bourli\u00e8re M, de Muret A, Sturm N, Hunault \nG, Penaranda G, Br\u00e9chot M-C, Trocme C, Cal\u00e8s P. \nDiagnostic accuracy, reproducibility and robustness \nof fibrosis blood tests in chronic hepatitis C: a me-\nta-analysis with individual data. Clin Biochem 2008; \n41:1368-76.","journal-title":"Clin Biochem"},{"key":"ref21","first-page":"4171","article-title":"Improved version 2.0 qualitative and quantitative Amplicor reverse transcription-PCR tests for hepatitis C virus RNA: calibration to international units, enhanced genotype reactivity, and performance characteristics","author":"SLeeS","year":"2000","unstructured":"Lee SC, Antony A, Lee N, Leibow J, Yang JQ, Sovie-\nro S, Gutekunst K, Rosenstraus M. Improved versi-\non 2.0 qualitative and quantitative Amplicor reverse \ntranscription-PCR tests for hepatitis C virus RNA: \ncalibration to international units, enhanced genoty-\npe reactivity, and performance characteristics. 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A non-invasive fibrosis score predicts treatment outcome in chronic hepatitis C virus infection","author":"JWestinJ","year":"2008","unstructured":"Westin J, Ydreborg M, Islam S, Alsi\u00f6 A, Dhillon AP, \nPawlotsky J-M, Zeuzem S, Schalm SW, Ferrari C, \nNeumann AU, Hellstrand K, Lagging M, DITTO-\nHCV Study Group. A non-invasive fibrosis score pre-\ndicts treatment outcome in chronic hepatitis C virus \ninfection. Scand J Gastroenterol 2008; 43:73-80.","journal-title":"Scand J Gastroenterol"},{"issue":"1","key":"ref24","article-title":"Meta-analyses of FibroTest diagnostic value in chronic liver disease","author":"TPoynardT","year":"2007","unstructured":"Poynard T, Morra R, Halfon P, Castera L, Ratziu V, \nImbert-Bismut F, Naveau S, Thabut D, Lebrec D, Zo-\nulim F, Bourliere M, Cacoub P, Messous D, Munte-\nanu M, de Ledinghen V. Meta-analyses of FibroTest \ndiagnostic value in chronic liver disease. BMC Ga-\nstroenterology 2007; 7(1).","journal-title":"BMC Gastroenterology"},{"key":"ref25","first-page":"2589","article-title":"FibroTest and Fi-broScan for the prediction of hepatitis C-related fibrosis: a systematic review of diagnostic test accuracy","author":"AamShaheenAam","year":"2007","unstructured":"Shaheen AAM, Wan AF, Myers RP. FibroTest and Fi-\nbroScan for the prediction of hepatitis C-related fibro-\nsis: a systematic review of diagnostic test accuracy. \nAm J Gastroenterol 2007; 102:2589-600.","journal-title":"Am J Gastroenterol"},{"key":"ref26","first-page":"48","article-title":"Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C","author":"MZiolM","year":"2004","unstructured":"Ziol M, Handra-Luca A, Kettaneh A, Christidis C, \nMal F, Kazemi F, de L\u00e9dinghen V, Marcellin P, Dhu-\nmeaux D, Trinchet J-C, Beaugrand M. 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Expert Rev Gastroenterol He-\npatol 2019; 13:361-74.","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"ref31","first-page":"628","article-title":"Online combination algorithm for non-invasive assessment of chronic hepatitis B related liver fibrosis and cirrhosis in resource-limited settings","author":"NSalkicN","year":"2015","unstructured":"Salkic NN, Cickusic E, Jovanovic P, Denjagic MB, \nIljazovic-Topcic S, Bevanda M, Ahmetagic S. Online \ncombination algorithm for non-invasive assessment \nof chronic hepatitis B related liver fibrosis and cirr-\nhosis in resource-limited settings. Eur J Intern Med \n2015; 26:628-34.","journal-title":"Eur J Intern Med"},{"key":"ref32","first-page":"461","article-title":"European Association for the Study of the Liver. EASL Recommendations on treatment of hepatitis C 2018","year":"2018","unstructured":"European Association for the Study of the Liver. \nEASL Recommendations on treatment of hepatitis C \n2018. J Hepatol 2018; 69:461-511.","journal-title":"J Hepatol"},{"key":"ref33","first-page":"95","article-title":"Technology Insight: noninvasive assessment of liver fibrosis by biochemical scores and elastography","author":"MPinzaniM","year":"2008","unstructured":"Pinzani M, Vizzutti F, Arena U, Marra F. Technology \nInsight: noninvasive assessment of liver fibrosis by \nbiochemical scores and elastography. Nat Clin Pract \nGastroenterol Hepatol 2008; 5:95-106.","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"ref34","first-page":"796","article-title":"Fibro-Test\/Fibrosure for significant liver fibrosis and cirrhosis in chronic hepatitis B: a meta-analysis","author":"NSalkicN","year":"2014","unstructured":"Salkic NN, Jovanovic P, Hauser G, Brcic M. Fibro-\nTest\/Fibrosure for significant liver fibrosis and cirr-\nhosis in chronic hepatitis B: a meta-analysis. 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J Hepatol \n2009; 50:36-41.","journal-title":"J Hepatol"},{"key":"ref37","first-page":"1449","article-title":"Sampling variability of liver fibrosis in chronic hepatitis C","author":"PBedossaP","year":"2003","unstructured":"Bedossa P, Dargere D, Paradis V. Sampling variabi-\nlity of liver fibrosis in chronic hepatitis C. Hepatology \n2003; 38:1449-57.","journal-title":"Hepatology"},{"key":"ref38","first-page":"991","article-title":"Liver fibrosis diagnosis by blood test and elastography in chronic hepatitis C: agreement or combination?","author":"PCal\u00e8sP","year":"2017","unstructured":"Cal\u00e8s P, Boursier J, Lebigot J, de Ledinghen V, Aub\u00e9 \nC, Hubert I, Oberti F. Liver fibrosis diagnosis by blo-\nod test and elastography in chronic hepatitis C: agree-\nment or combination? 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World J \nGastroenterol 2009; 15:2190.","journal-title":"World J Gastroenterol"}],"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/80\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/80\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:44:17Z","timestamp":1775468657000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/235\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,9]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,10,9]]},"published-print":{"date-parts":[[2020,10,9]]}},"URL":"https:\/\/doi.org\/10.17392\/1269-21","archive":["Internet Archive"],"relation":{},"ISSN":["1840-0132","1840-0132"],"issn-type":[{"value":"1840-0132","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10,9]]}}}