{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:07:56Z","timestamp":1790878076791,"version":"4.1.0"},"reference-count":20,"publisher":"Medical Association of Zenica-Doboj","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2020,10,9]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;The septic non-union is a common compliance in bone healing due to bone infection. Bone resection, associated with Ilizarov osteo-distraction technique, is commonly used in these cases. The aim of this study was to analyse clinical and radiological results of teriparatide in combination with the Ilizarov technique and to compare this treatment with the standard treatment.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;Forty adult patients underwent surgery because of type C of the Association for the Study and Application of Methods&amp;lt;br \/&amp;gt;of Ilizarov (ASAMI) classification non-union were enrolled. The patients were divided in two groups: those treated with Ilizarov technique (Norm group) and those treated with Ilizarov technique combined with teriparatide injection (Teri group). Surgical duration, complication rate, bone healing status, clinical and functional outcomes were assessed according to the A.S.A.M.I. classification in the mean follow-up of 12 months. The subjective quality of life was assessed by the Short Form Survey (SF)-12.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Results&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;Teri group showed less time wearing Ilizarov&amp;#039;s frame (p&amp;amp;lt;0.05) than the Norm group and a statistical significance in the inter-rater reliability Cohen&amp;amp;rsquo;s k (p&amp;amp;gt;0.05) respect to Norm according the score between the bone healing and clinical outcome results. There was no statistically significant difference between the two groups in other parameters that were assessed.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusion&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;A benefit of teriparatide was found as adjuvant in the treatment of septic non-union.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1280-21","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T10:28:16Z","timestamp":1713695296000},"page":"287-292","source":"Crossref","is-referenced-by-count":7,"title":["Effectiveness of teriparatide combined with the Ilizarov technique in septic tibial non-union"],"prefix":"10.17392","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1920-1286","authenticated-orcid":false,"given":"Giuseppe","family":"Rollo","sequence":"first","affiliation":[{"name":"Vito Fazzi Hospital","place":["Lecce,Italy"],"department":["Department of Orthopaedics and Traumatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Luceri","sequence":"additional","affiliation":[{"name":"Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Ortopedico Galeazzi","place":["Milan,Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Falzarano","sequence":"additional","affiliation":[{"name":"AORN SAN PIO \u201cGaetano Rummo Hospital\u201d","place":["Benevento,Italy"],"department":["Department of Orthopaedics and Traumatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Salomone","sequence":"additional","affiliation":[{"name":"Malattie Infettive Osteo-Articolari MIOS, S. Maria di Misericordia Hospital","place":["Savona,Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico Maria","family":"Bonura","sequence":"additional","affiliation":[{"name":"Poliambulanza Foundation Hospital","place":["Brescia,Italy"],"department":["Department of Orthopaedics and Traumatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry","family":"Popkov","sequence":"additional","affiliation":[{"name":"Russian Ilizarov Scientific Centre \u201cReconstructive Traumatology and Orthopaedics\u201d","place":["Kurgan,Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Ronga","sequence":"additional","affiliation":[{"name":"University of Molise","place":["Campobasso,Italy"],"department":["Department of Medicine and Health Sciences 'Vincenzo Tiberio'"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Pica","sequence":"additional","affiliation":[{"name":"AORN SAN PIO \u201cGaetano Rummo Hospital\u201d","place":["Benevento,Italy"],"department":["Department of Orthopaedics and Traumatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Bisaccia","sequence":"additional","affiliation":[{"name":"University of Perugia, \u201cS. Maria della Misericordia\u201d Hospital","place":["Perugia,Italy"],"department":["Division of Orthopaedics and Trauma Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Russi","sequence":"additional","affiliation":[{"name":"Vito Fazzi Hospital","place":["Lecce,Italy"],"department":["Department of Orthopaedics and Traumatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Predrag","family":"Grubor","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Banja Luka","place":["Banja Luka,Bosnia and Herzegovina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Franzese","sequence":"additional","affiliation":[{"name":"Orthopaedics and Traumatology Unit, Villa del Sole Caserta, Caserta","place":["Caserta,Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe M.","family":"Peretti","sequence":"additional","affiliation":[{"name":"Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Ortopedico Galeazzi","place":["Milan,Italy"]},{"name":"University of Milan","place":["Milan,Italy"],"department":["Department of Biomedical Sciences for Health"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Meccariello","sequence":"additional","affiliation":[{"name":"AORN SAN PIO \u201cGaetano Rummo Hospital\u201d","place":["Benevento,Italy"],"department":["Department of Orthopaedics and Traumatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"49509","published-online":{"date-parts":[[2020,10,9]]},"reference":[{"issue":"Suppl 6","key":"ref1","first-page":"93","article-title":"Validation of the Non-Union Scoring System in 300 long bone nonunions","author":"GCaloriG","year":"2014","unstructured":"Calori GM, Colombo M, Mazza EL, Mazzola S, \nMalagoli E, Marelli N, Corradi A. Validation of the \nNon-Union Scoring System in 300 long bone non-\nunions. Injury 2014; 45(Suppl 6):S93-7.","journal-title":"Injury"},{"key":"ref2","first-page":"256","article-title":"Infected non-union of tibia","author":"MChaudharyM","year":"2017. 2017","unstructured":"Chaudhary MM (2017) Infected non-union of tibia. \nIndian J Orthop 2017; 51:256-68.","journal-title":"Indian J Orthop"},{"key":"ref3","first-page":"145","article-title":"Contribution of G.A. Ilizarov to bone reconstruction: historical achievements and state of the art","author":"AGubinA","year":"2016","unstructured":"Gubin AV, Borzunov DY, Marchenkova LO, Malko-\nva TA, Smirnova IL. Contribution of G.A. Ilizarov \nto bone reconstruction: historical achievements and \nstate of the art. Strategies Trauma Limb Reconstr \n2016; 11:145-52.","journal-title":"Strategies Trauma Limb Reconstr"},{"key":"ref4","first-page":"7","article-title":"Treatment of the chronic war tibial osteomyelitis, Gustilo type IIIB and Cierny-Mader IIIB, using various methods. A Retrospective study","author":"PGruborP","year":"2014","unstructured":"Grubor P, Falzarano G, Grubor M, Piscopo A, Fran-\nzese R, Meccariello L. Treatment of the chronic war \ntibial osteomyelitis, Gustilo type IIIB and Cierny-\nMader IIIB, using various methods. A Retrospective \nstudy. EMBJ 2014; 9:7-18.","journal-title":"EMBJ"},{"key":"ref5","first-page":"260","article-title":"Treatment of bone defects in war wounds: retrospective study","author":"PGruborP","year":"2015. 2015","unstructured":"Grubor P, Milicevic S, Grubor M, Meccariello L \n(2015) Treatment of bone defects in war wounds: \nretrospective study. Med Arh 2015; 69:260-4.","journal-title":"Med Arh"},{"key":"ref6","first-page":"39","article-title":"Role of teriparatide in accelerating metatarsal stress fracture healing: a case series and review of literature","author":"PRaghavanP","year":"2012","unstructured":"Raghavan P, Christofides E. Role of teriparatide in \naccelerating metatarsal stress fracture healing: a case \nseries and review of literature. Clin Med Insights \nEndocrinol Diabetes 2012; 5:39-45.","journal-title":"Clin Med Insights Endocrinol Diabetes"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1359\/jbmr.1999.14.6.960","article-title":"Intermittent parathyroid hormone (1-34) treatment increases callus formation and mechanical strength of healing rat fractures","author":"TAndreassenT","year":"1999","unstructured":"Andreassen TT, Ejersted C, Oxlund H. Intermittent \nparathyroid hormone (1-34) treatment increases \ncallus formation and mechanical strength of healing \nrat fractures. J Bone Miner Res 1999; 14:960-8.","journal-title":"J Bone Miner Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1359\/jbmr.090731","article-title":"Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind-study of 102 postmenopausal women with distal radial fractures","author":"PAspenbergP","year":"2010","unstructured":"Aspenberg P, Genant HK, Johansson T, Nino \nAJ, See K, Krohn K, Garc\u00eda-Hern\u00e1ndez PA, Recknor \nCP, Einhorn TA, Dalsky GP, Mitlak BH, Fierlinger \nA, Lakshmanan MC. Teriparatide for acceleration of \nfracture repair in humans: a prospective, randomi-\nzed, double-blind-study of 102 postmenopausal wo-\nmen with distal radial fractures. J Bone Miner Res \n2010; 25:404-14.","journal-title":"J Bone Miner Res"},{"key":"ref9","first-page":"426","article-title":"The treatment of infected tibial non-union by bone transport using the Ilizarov external fixator and a systematic review of infected tibial non-union treated by Ilizarov methods","author":"PYinP","year":"2014","unstructured":"Yin P, Zhang Q, Mao Z, Li T, Zhang L, Tang P. The \ntreatment of infected tibial non-union by bone tran-\nsport using the Ilizarov external fixator and a syste-\nmatic review of infected tibial non-union treated by \nIlizarov methods. Acta Orthop Belg 2014; 80:426-35.","journal-title":"Acta Orthop Belg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jos.2017.03.002","article-title":"Outcomes of the Ilizarov frame use in elderly patients","author":"EIliopoulosE","year":"2017","unstructured":"Iliopoulos E, Morrissey N, Cho S, Khaleel A. Outco-\nmes of the Ilizarov frame use in elderly patients. J \nOrthop Sci 2017; 22:783-6.","journal-title":"J Orthop Sci"},{"issue":"Suppl 1","key":"ref11","article-title":"Epidemiology of fracture nonunion in 18 human bones","author":"DHakD","year":"2017","unstructured":"Hak DJ. Editorial on \"Epidemiology of fracture no-\nnunion in 18 human bones\". Ann Transl Med 2017; \n5(Suppl 1):S19.","journal-title":"Ann Transl Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.orthres.2003.08.018","article-title":"Intermittent parathyroid hormone (1-34) enhances mechanical strength and density of new bone after distraction osteogenesis in rats","author":"CSeebachC","year":"2004","unstructured":"Seebach C, Skripitz R, Andreassen TT, Aspenberg \nP. Intermittent parathyroid hormone (1-34) enhances \nmechanical strength and density of new bone after \ndistraction osteogenesis in rats. J Orthop Res 2004; \n22:472-8.","journal-title":"J Orthop Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.2106\/JBJS.J.01379","article-title":"Parathyroid hormone 1-84 accelerates fracture-healing in pubic bones of elderly osteoporotic women","author":"PPeichlP","year":"2011","unstructured":"Peichl P, Holzer LA, Maier R, Holzer G. Parathyroid \nhormone 1-84 accelerates fracture-healing in pubic \nbones of elderly osteoporotic women. J Bone Joint \nSurg Am 2011; 93:1583-7.","journal-title":"J Bone Joint Surg Am"},{"key":"ref14","first-page":"1478","article-title":"Daily subcutaneous teriparatide injection increased bone mineral density of newly formed bone after tibia distraction osteogenesis, a randomized study","author":"FWagnerF","year":"2019","unstructured":"Wagner F, Vach W, Augat P, Varady PA, Panzer S, \nKeiser S, Eckardt H. Daily subcutaneous teriparati-\nde injection increased bone mineral density of newly \nformed bone after tibia distraction osteogenesis, a \nrandomized study. Injury 2019; 50:1478-82.","journal-title":"Injury"},{"key":"ref15","first-page":"47","article-title":"Teriparatide in fracture non-unions","author":"CCoppolaC","year":"2014","unstructured":"Coppola C, Del Buono A, Maffulli N. Teriparatide in \nfracture non-unions. Transl Med UniSa 2014; 12:47-\n53.","journal-title":"Transl Med UniSa"},{"key":"ref16","first-page":"153","article-title":"Distraction osteogenesis for tibial nonunion with bone loss using combined Ilizarov and Taylor spatial frames versus a conventional circular frame","author":"IAbuomiraI","year":"2016","unstructured":"Abuomira IE, Sala F, Elbatrawy Y, Lovisetti G, Alati \nS, Capitani D. Distraction osteogenesis for tibial no-\nnunion with bone loss using combined Ilizarov and \nTaylor spatial frames versus a conventional circu-\nlar frame. Strategies Trauma Limb Reconstr. 2016; \n11:153-9.","journal-title":"Strategies Trauma Limb Reconstr"},{"key":"ref17","first-page":"136","article-title":"Teriparatide as a systemic treatment for lower extremity nonunion fractures: a case series","author":"EMancillaE","year":"2015","unstructured":"Mancilla EE, Brodsky JL, Mehta S, Pignolo RJ, Le-\nvine MA. Teriparatide as a systemic treatment for \nlower extremity nonunion fractures: a case series. \nEndocr Pract 2015; 21:136-42.","journal-title":"Endocr Pract"},{"key":"ref18","first-page":"185446","article-title":"High dose teriparatide (rPTH1-34) therapy increases callus volume and enhances radiographic healing at 8-weeks in a massive canine femoral allograft model","author":"KNishitaniK","year":"2017","unstructured":"Nishitani K, Mietus Z, Beck CA, Ito H, Matsuda S, \nAwad HA, Ehrhart N, Schwarz EM. High dose te-\nriparatide (rPTH1-34) therapy increases callus volu-\nme and enhances radiographic healing at 8-weeks in \na massive canine femoral allograft model. PLoS One \n2017; 12:e0185446.","journal-title":"PLoS One"},{"key":"ref19","first-page":"28","article-title":"Use of teriparatide off-label: our experience and review of literature","author":"ECiurliaE","year":"2017. 2017","unstructured":"Ciurlia E, Leali PT, Doria C (2017) Use of teriparati-\nde off-label: our experience and review of literature. \nClin Cases Miner Bone Metab 2017; 14:28-34.","journal-title":"Clin Cases Miner Bone Metab"},{"issue":"Suppl 1","key":"ref20","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0020-1383(13)70013-5","article-title":"Teriparatide in the treatment of non-unions: scientific and clinical evidences","author":"LPietrograndeL","year":"2013","unstructured":"Pietrogrande L, Raimondo E. Teriparatide in the tre-\natment of non-unions: scientific and clinical eviden-\nces. Injury 2013; 44(Suppl 1):S54-7.","journal-title":"Injury"}],"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/79\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/79\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:44:29Z","timestamp":1775468669000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/279\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,9]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,10,9]]},"published-print":{"date-parts":[[2020,10,9]]}},"URL":"https:\/\/doi.org\/10.17392\/1280-21","archive":["Internet Archive"],"relation":{"is-cited-by":[{"id-type":"doi","id":"10.5312\/wjo.v12.i8.515","asserted-by":"object"},{"id-type":"doi","id":"10.1186\/s13018-022-03021-8","asserted-by":"object"}]},"ISSN":["1840-0132","1840-0132"],"issn-type":[{"value":"1840-0132","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10,9]]}}}