{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:57:33Z","timestamp":1775473053382,"version":"3.50.1"},"reference-count":4,"publisher":"Medical Association of Zenica-Doboj","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2020,10,9]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim &amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt;Facial aesthetics is at present a concept intricately linked to the degree of self-esteem. Unwanted submental fat (SMF) leads to an unattractive submental profile. Sodium deoxicolate (ATX) -101 is the only injectable drug approved to decrease submental fat of moderate to severe intensity.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;We carried out a bibliographic review in PubMed using the key words: deoxycholic acid, ATX-101, and submental fat.&amp;lt;br \/&amp;gt;Only complete articles published between 2009 and 2019, and focused on submental fat were reviewed, excluding those articles relating to that spoke of deoxycholate in the treatment of fat in other locations or in which deoxycholate was associated with other drugs.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Results&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;In several phase III clinical trials, injection of 2 mg\/cm2 deoxycholic acid in SMF has reduced moderate-severe fullness compared to the placebo group. These results were maintained in most cases during a long follow-up period. Injections of&amp;lt;br \/&amp;gt;deoxycholic acid are generally well tolerated, with limited adverse effects in the treatment area, with a mild and complete resolution without sequelae. However, not all patients with SMF are suitable for deoxycholic acid therapy, and therefore a proper selection is very important to achieve the desired aesthetic results.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusion&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;Deoxycholic acid injections are effective and are a generally well-tolerated, minimally invasive option for the treatment&amp;lt;br \/&amp;gt;of moderate to severe intensity SMF in selected adults.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1328-21","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T10:28:16Z","timestamp":1713695296000},"page":"148-152","source":"Crossref","is-referenced-by-count":2,"title":["Current status of localized submental fat treatment with sodium deoxicolate (ATX-101)"],"prefix":"10.17392","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3391-8697","authenticated-orcid":false,"given":"Cristina","family":"Ib\u00e1\u00f1ez-Vicente","sequence":"first","affiliation":[{"name":"\"Hospital de Getafe\u201d","place":["Madrid,Spain"],"department":["Department of General Medicine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Carrato-Gomez","sequence":"additional","affiliation":[{"name":"\u201cComplejo Hospitalario Universitario de Toledo\"","place":["Toledo,Spain"],"department":["Division of Orthopaedics and Trauma Surgery"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Meccariello","sequence":"additional","affiliation":[{"name":"\"Ospedali Riuniti di Ancona\"","place":["Ancona,Italy"],"department":["Division of Anaesthesia, Analgesia and Intensive Care and Pain Therapy, Department of Emergency and Major Trauma"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Ripani","sequence":"additional","affiliation":[{"name":"\"Ospedali Riuniti di Ancona\"","place":["Ancona,Italy"],"department":["Division of Anaesthesia, Analgesia and Intensive Care and Pain Therapy, Department of Emergency and Major Trauma"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Bisaccia","sequence":"additional","affiliation":[{"name":"S.M. Misericordia Hospital, University of Perugia, Sant'Andrea delle Fratte","place":["Perugia,Italy"],"department":["Orthopaedics and Traumatology Unit, Department of Surgical and Biomedical Science"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49509","published-online":{"date-parts":[[2020,10,9]]},"reference":[{"key":"ref1","first-page":"27","article-title":"Perceptions and practices in submental fat treatment: a survey of physicians and patients","author":"JSchlessingerJ","year":"2013","unstructured":"Schlessinger J, Weiss SR, Jewell M, Narurkar \nV, Weinkle S, Gold MH, Bazerkanian E. Percep-\ntions and practices in submental fat treatment: a \nsurvey of physicians and patients. Skinmed 2013; \n11:27-31.","journal-title":"Skinmed"},{"key":"ref2","first-page":"174","article-title":"The development, evidence, and current use of ATX-101 for the treatment of submental fat","author":"CGeorgesenC","year":"2017","unstructured":"Georgesen C, Lipner SR. The development, eviden-\nce, and current use of ATX-101 for the treatment of \nsubmental fat. J Cosmet Dermatol 2017; 16:174-9.","journal-title":"J Cosmet Dermatol"},{"key":"ref3","first-page":"115","article-title":"Aging and cosmetic enhancement","author":"RHonigmanR","year":"2006","unstructured":"Honigman R, Castle DJ. Aging and cosmetic enhan-\ncement. Clin Interv Aging 2006; 1:115-9.","journal-title":"Clin Interv Aging"},{"key":"ref4","first-page":"1001","article-title":"Detergent effects of sodium deoxycholate are a major feature of an injectable phosphatidylcholine formulation used for localized fat dissolution","author":"ARotundaA","year":"2004","unstructured":"Rotunda AM, Suzuki H, Moy RL, Kolodney MS. \nDetergent effects of sodium deoxycholate are a ma-\njor feature of an injectable phosphatidylcholine for-\nmulation used for localized fat dissolution. Dermatol \nSurg 2004; 30:1001-8","journal-title":"Dermatol Surg"}],"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/331\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/331\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:44:15Z","timestamp":1775468655000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/224\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,9]]},"references-count":4,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,10,9]]},"published-print":{"date-parts":[[2020,10,9]]}},"URL":"https:\/\/doi.org\/10.17392\/1328-21","archive":["Internet Archive"],"relation":{},"ISSN":["1840-0132","1840-0132"],"issn-type":[{"value":"1840-0132","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10,9]]}}}