{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:57:32Z","timestamp":1775473052458,"version":"3.50.1"},"reference-count":29,"publisher":"Medical Association of Zenica-Doboj","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim &amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt;To evaluate the possibility of retinal haemorrhages or any other retinal pathology caused by febrile seizures alone in children aged between 2 months and 15 years.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;Children aged between 2 months and 15 years admitted to the hospital following seizures were examined within 48 hours&amp;lt;br \/&amp;gt;of admission. The seizures were classified by a paediatric neurologist and a detailed ocular examination, including indirect ophthalmoscopy, was performed by an ophthalmologist.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Results&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;In the period between May 2019 and May 2020 a total number of 106 children were examined. There were 66 (62.3%)&amp;lt;br \/&amp;gt;male and 40 (37.7%) female children. The youngest patient was 2 months old and the oldest patient was 15 years old. None of the children was found to have retinal haemorrhages or any other retinal pathology.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusion&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;Retinal haemorrhages or any other acute retinal findings in children with febrile seizures are very rare, but we cannot&amp;lt;br \/&amp;gt;rule out its occurrence. The finding of retinal haemorrhages in a child admitted with a history of seizure should trigger a detailed search for other causes of those haemorrhages, especially shaken baby syndrome. Due to the lack of any manifestations on the retina after febrile seizure, maybe it is time that the current protocol and guidelines, considering obligatory fundus examination, should be re-examined&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1366-21","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T10:28:16Z","timestamp":1713695296000},"page":"427-431","source":"Crossref","is-referenced-by-count":0,"title":["Retinal changes in febrile seizures in children: a retrospective analysis in Tuzla Canton, Bosnia and Herzegovina"],"prefix":"10.17392","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4702-817X","authenticated-orcid":false,"given":"Meliha","family":"Halilba\u0161i\u0107","sequence":"first","affiliation":[{"name":"University Clinical Centre Tuzla","place":["Tuzla,Bosnia and Herzegovina"],"department":["Eye Clinic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amra","family":"Nadarevi\u0107 Voden\u010darevi\u0107","sequence":"additional","affiliation":[{"name":"University Clinical Centre Tuzla","place":["Tuzla,Bosnia and Herzegovina"],"department":["Eye Clinic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anis","family":"Me\u0111edovi\u0107","sequence":"additional","affiliation":[{"name":"University Clinical Centre Tuzla","place":["Tuzla,Bosnia and Herzegovina"],"department":["Eye Clinic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Halilba\u0161i\u0107","sequence":"additional","affiliation":[{"name":"University Clinical Center Tuzla","place":["Tuzla,Bosnia and Herzegovina"],"department":["Clinic for Children\u2019s Diseases"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almira","family":"\u0106osi\u0107ki\u0107","sequence":"additional","affiliation":[{"name":"University Clinical Center Tuzla","place":["Tuzla,Bosnia and Herzegovina"],"department":["Clinic for Children\u2019s Diseases"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajla","family":"Pidro","sequence":"additional","affiliation":[{"name":"Eye Clinic Dr. Ismail","place":["Sarajevo,Bosnia and Herzegovina"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49509","published-online":{"date-parts":[[2021,6,1]]},"reference":[{"key":"ref1","first-page":"212536","article-title":"Febrile seizures: an overview","author":"ALeungA","year":"2018","unstructured":"Leung AK, Hon KL, Leung TN. Febrile seizures: an \noverview. Drugs Context 2018; 7:212536.","journal-title":"Drugs Context"},{"key":"ref2","first-page":"4240","article-title":"Febrile seizures","author":"NPatelN","year":"2015","unstructured":"Patel N, Ram D, Swiderska N, Mewasingh LD, \nNewton RW, Offringa M. Febrile seizures. BMJ \n2015; 351:h4240.","journal-title":"BMJ"},{"key":"ref3","first-page":"14","article-title":"Febrile convulsions in children","author":"SPaulS","year":"2015","unstructured":"Paul SP, Seymour M, Flower D, Rogers E. Febrile \nconvulsions in children. Nurs Child Young People \n2015; 27:14-15.","journal-title":"Nurs Child Young People"},{"key":"ref4","first-page":"445","article-title":"Febrile Seizures: Risks, evaluation, and prognosis","author":"DSmithD","year":"2019","unstructured":"Smith DK, Sadler KP, Benedum M. Febrile Se-\nizures: Risks, evaluation, and prognosis. Am Fam \nPhysician. 2019; 99:445-50.","journal-title":"Am Fam Physician"},{"key":"ref5","first-page":"27","article-title":"Circadian rhythm and the seasonal variation in childhood febrile seizure","author":"RSharafiR","year":"2017","unstructured":"Sharafi R, Hassanzadeh RA, Aminzadeh V. Circadi-\nan rhythm and the seasonal variation in childhood \nfebrile seizure. Iran J Child Neurol 2017; 11:27-30.","journal-title":"Iran J Child Neurol"},{"key":"ref6","first-page":"9","article-title":"Seasonal distribution of febrile seizure and the relationship with respiratory and enteric viruses in Korean children based on nationwide registry data","author":"DHanD","year":"2019","unstructured":"Han DH, Kim SY, Lee NM, Yi DY, Yun SW, Lim IS, \nChae SA. Seasonal distribution of febrile seizure and \nthe relationship with respiratory and enteric viruses \nin Korean children based on nationwide registry \ndata. Seizure 2019; 73:9-13.","journal-title":"Seizure"},{"key":"ref7","first-page":"1598","article-title":"Clinical, epidemiological and laboratory characteristics of children with febrile seizures","author":"PShankarP","year":"2020","unstructured":"Shankar P, Mahamud S. Clinical, epidemiological \nand laboratory characteristics of children with febri-\nle seizures.Int J Contemp Pediatr 2020; 7:1598-605.","journal-title":"Int J Contemp Pediatr"},{"key":"ref8","first-page":"2232","article-title":"Management of pediatric febrile seizures","author":"DLainoD","year":"2018","unstructured":"Laino D, Mencaroni E, Esposito S. Management of \npediatric febrile seizures. Int J Environ Res Public \nHealth 2018; 15:2232.","journal-title":"Int J Environ Res Public Health"},{"key":"ref9","article-title":"Nelson Textbook of Pediatrics","author":"RKliegmanR","year":"2020","unstructured":"Kliegman R, Geme J. Nelson Textbook of Pedia-\ntrics. 21th ed. Philadelphia: Elsevier, 2020."},{"key":"ref10","first-page":"430","article-title":"Patterns of retinal hemorrhage associated with increased intracranial pressure in children","author":"GBinenbaumG","year":"2013","unstructured":"Binenbaum G, Rogers DL, Forbes BJ. Patterns of \nretinal hemorrhage associated with increased intra-\ncranial pressure in children. Pediatrics 2013; 132: \ne430-e434.","journal-title":"Pediatrics"},{"key":"ref11","first-page":"623","article-title":"Retinal hemorrhages in children: the role of intracranial pressure","author":"TShiauT","year":"2012","unstructured":"Shiau T, Levin AV. Retinal hemorrhages in children: \nthe role of intracranial pressure. Arch Pediatr Ado-\nlesc Med 2012; 166:623-8.","journal-title":"Arch Pediatr Adolesc Med"},{"key":"ref12","article-title":"Retinal findings in young children with increased intracranial pressure from nontraumatic causes","author":"AShiA","year":"2019. 20181182","unstructured":"Shi A, Kulkarni A, Feldman KW. Retinal findings \nin young children with increased intracranial pre-\nssure from nontraumatic causes. Pediatrics 2019; \n143:e20181182.","journal-title":"Pediatrics"},{"key":"ref13","first-page":"233","article-title":"Retinal hemorrhage in the young child: a review of etiology, predisposed conditions, and clinical implications","author":"MGayleM","year":"1995","unstructured":"Gayle MO, Kissoon N, Hered RW, Harwood-Nuss. \nRetinal hemorrhage in the young child: a review of \netiology, predisposed conditions, and clinical impli-\ncations. J Emerg Med 1995; 13:233-9.","journal-title":"J Emerg Med"},{"key":"ref14","first-page":"1","article-title":"Fundus hemorrhages in infancy","author":"BKaurB","year":"1992","unstructured":"Kaur B, Taylor D. Fundus hemorrhages in infancy. \nSurv Ophthalmol 1992; 37:1-17.","journal-title":"Surv Ophthalmol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1136\/adc.86.5.334","article-title":"Convulsions and retinal hemorrhage: should we look further?","author":"MMei-ZahavM","year":"2002","unstructured":"Mei-Zahav M, Uziel Y, Raz J, Ginot N, Wolach B, \nFainmesser P. Convulsions and retinal hemorrha-\nge: should we look further? Arch Dis Child 2002; \n86:334-5.","journal-title":"Arch Dis Child"},{"key":"ref16","article-title":"Febrile Convulsions Clinical Guideline V4","year":"03 April 2021","unstructured":"Royal Cornwall Hospitals NHS Trust. Febrile Con-\nvulsions Clinical Guideline V4.0 https:\/\/doclibrary-\nrcht.cornwall.nhs.uk\/GET\/d10290030 (03 April \n2021)"},{"key":"ref17","article-title":"The Febrile Seizure","author":"DAlexanderD","year":"03 April 2021","unstructured":"Alexander D. The Febrile Seizure http:\/\/brownem-\nblog.com\/blog-1\/2020\/7\/31\/the-febrile-seizure (03 \nApril 2021)"},{"key":"ref18","article-title":"Census of population, households and dwellings in Bosnia and Herzegovina","year":"2013. 19 September 2020","unstructured":"Agency for Statistics of Bosnia and Herzegovina. \nCensus of population, households and dwellings in \nBosnia and Herzegovina, 2013. http:\/\/www.statisti-\nka.ba\/?lang=en (19 September 2020)"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1136\/bmj.311.7005.619","article-title":"Probability of adverse events that have not yet occurred: a statistical reminder","author":"EEypaschE","year":"1995","unstructured":"Eypasch E, Lefering R, Kum CK, Troidl H. Proba-\nbility of adverse events that have not yet occurred: a \nstatistical reminder. BMJ 1995; 311:619-20.","journal-title":"BMJ"},{"key":"ref20","first-page":"1743","article-title":"If nothing goes wrong, is everything all right? Interpreting zero numerators","author":"JHanleyJ","year":"1983","unstructured":"Hanley JA, Lippman-Hand A. If nothing goes \nwrong, is everything all right? Interpreting zero nu-\nmerators. JAMA 1983; 249:1743-5.","journal-title":"JAMA"},{"key":"ref21","first-page":"77","article-title":"Febrile seizures: Are they truly benign? Longitudinal analysis of risk factors and future risk of afebrile epileptic seizure based on the national sample cohort in South Korea","author":"YChoiY","year":"2002-2013. 2019","unstructured":"Choi YJ, Jung JY, Kim JH, Kwon H, Park JW, Kwak \nYH, Kim DK, Lee JH. Febrile seizures: Are they \ntruly benign? Longitudinal analysis of risk factors \nand future risk of afebrile epileptic seizure based on \nthe national sample cohort in South Korea, 2002-\n2013. Seizure 2019; 64:77-83.","journal-title":"Seizure"},{"key":"ref22","first-page":"1164","article-title":"Evaluation of long-term risk of epilepsy, psychiatric disorders, and mortality among children with recurrent febrile seizures: a national cohort study in Denmark","author":"JDreierJ","year":"2019","unstructured":"Dreier JW, Li J, Sun Y, Christensen J. Evaluation of \nlong-term risk of epilepsy, psychiatric disorders, and \nmortality among children with recurrent febrile se-\nizures: a national cohort study in Denmark. JAMA \nPediatr 2019; 173:1164-70.","journal-title":"JAMA Pediatr"},{"key":"ref23","first-page":"424","article-title":"Diurnal and seasonal occurrence of febrile seizures","author":"KMikkonenK","year":"2015","unstructured":"Mikkonen K, Uhari M, Pokka T, Rantala H. Diurnal \nand seasonal occurrence of febrile seizures. Pediatr \nNeurol 2015; 52:424-427.","journal-title":"Pediatr Neurol"},{"key":"ref24","first-page":"29","article-title":"Diurnal and seasonal occurrence of febrile seizures","author":"JMillichapJ","year":"2015","unstructured":"Millichap JJ, Millichap JG. Diurnal and seasonal \noccurrence of febrile seizures. Pediatr Neurol Briefs \n2015; 29:29.","journal-title":"Pediatr Neurol Briefs"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1136\/adc.76.5.449","article-title":"Retinal hemorrhages and convulsions","author":"SSandramouliS","year":"1997","unstructured":"Sandramouli S, Robinson R, Tsaloumas M. Retinal \nhemorrhages and convulsions. Archives of Disease \nin Childhood 1997; 76:449-451.","journal-title":"Archives of Disease in Childhood"},{"key":"ref26","first-page":"659","article-title":"Can convulsions alone cause retinal hemorrhages in infants?","author":"ATyagiA","year":"1998","unstructured":"Tyagi AK, Scotcher S, Kozeis N, Willshaw HE. Can \nconvulsions alone cause retinal hemorrhages in in-\nfants? Br J Ophthalmol 1998; 82: 659-660.","journal-title":"Br J Ophthalmol"},{"key":"ref27","first-page":"182","article-title":"Manifestations of ocular fundus in children with febrile seizures","author":"HGuoH","year":"2011","unstructured":"Guo H, Lan Y, Wang M, Xiao J, Hu Y, Xia Z. Ma-\nnifestations of ocular fundus in children with febri-\nle seizures. J Pediatr Ophthalmol Strabismus 2011; \n48:182-186.","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"ref28","article-title":"Klinicke karakteristike prvih febrilnih konvulzija (Clinical characteristics at onset of first febrile convulsions)","author":"NMustafi\u0107N","unstructured":"Mustafi\u0107 N, Tahirovi\u0107 H, Trnovcevi\u0107 J, Kapidzi\u0107 \nA. Klinicke karakteristike prvih febrilnih konvul-\nzija (Clinical characteristics at onset of first febrile \nconvulsions) [in Croatian]."},{"key":"ref29","first-page":"511","year":"2008","unstructured":"Acta Med Croatica 2008; \n62:511-515.","journal-title":"Acta Med Croatica"}],"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/301\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/301\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:44:14Z","timestamp":1775468654000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/221\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,1]]},"references-count":29,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,6,1]]},"published-print":{"date-parts":[[2021,6,1]]}},"URL":"https:\/\/doi.org\/10.17392\/1366-21","archive":["Internet Archive"],"relation":{},"ISSN":["1840-0132","1840-0132"],"issn-type":[{"value":"1840-0132","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6,1]]}}}