{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:58:10Z","timestamp":1775473090452,"version":"3.50.1"},"reference-count":28,"publisher":"Medical Association of Zenica-Doboj","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;This case-control study aimed to determine a possible association of single nucleotide polymorphism rs211037 of the&amp;lt;br \/&amp;gt;gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2) gene with the susceptibility to idiopathic generalized epilepsy (IGE) in the Macedonian population.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;It enrolled 96 patients with clinically verified IGE and 51 healthy individuals without personal and family history of epilepsy or other neurological disorders as controls. A determination of the GABRG2 rs211037 polymorphism was performed using the TaqMan-based genotyping assay.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Results&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;A significant dominant association of the CC genotype (odds ratio - OR=2.100, 95% CI=1.018-4.332; p=0.043) and allelic association of C allele (OR=1.902, CI=1.040-3.477; p=0.035) with susceptibility to IGE was found. Carriers of CC genotype&amp;lt;br \/&amp;gt;had approximately a 2-fold higher probability of developing IGE than the carriers of CT and TT genotypes. Carriers of the C allele had a 1.9-folds higher probability for IGE than the carriers of the T allele.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusion&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;The polymorphism rs211037 of the GABRG2 gene increases the risk of the development of idiopathic generalized&amp;lt;br \/&amp;gt;epilepsy in the Macedonian population.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1367-21","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T10:28:16Z","timestamp":1713695296000},"page":"404-409","source":"Crossref","is-referenced-by-count":2,"title":["Association of rs211037 GABRG2 gene polymorphism with susceptibility to idiopathic generalized epilepsy"],"prefix":"10.17392","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1652-4661","authenticated-orcid":false,"given":"Marija","family":"Milanovska","sequence":"first","affiliation":[{"name":"University Clinic of Neurology, Saints Cyril and Methodius University","place":["Skopje,North Macedonia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilija","family":"Cvetkovska","sequence":"additional","affiliation":[{"name":"Neuromedica Hospital","place":["Skopje,North Macedonia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasho","family":"Panov","sequence":"additional","affiliation":[{"name":"Saints Cyril and Methodius University","place":["Skopje,North Macedonia"],"department":["Department of Molecular Biology and Genetics"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49509","published-online":{"date-parts":[[2021,6,1]]},"reference":[{"key":"ref1","first-page":"40224","article-title":"Structure, function, and modulation of GABAA receptors","author":"ESigelE","year":"2012","unstructured":"Sigel E, Steinmann ME. 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JAMA Neurol \n2016; 73:1009-16.","journal-title":"JAMA Neurol"}],"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/364\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/364\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:44:38Z","timestamp":1775468678000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/321\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,1]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,6,1]]},"published-print":{"date-parts":[[2021,6,1]]}},"URL":"https:\/\/doi.org\/10.17392\/1367-21","archive":["Internet Archive"],"relation":{"is-cited-by":[{"id-type":"doi","id":"10.2147\/PGPM.S329594","asserted-by":"object"}]},"ISSN":["1840-0132","1840-0132"],"issn-type":[{"value":"1840-0132","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6,1]]}}}