{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T21:05:03Z","timestamp":1781298303573,"version":"3.54.1"},"reference-count":36,"publisher":"Medical Association of Zenica-Doboj","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim &amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt;Allergic rhinitis (AR) is a heterogeneous condition that has been associated with inflammatory responses and is characterized by clinical typical symptoms of nasal itching, sneezing, watery discharge and congestion. Mesenchymal stem cells (MSCs) are multipotent stem cells that have the immunoregulatory ability by secreting various cytokines which potent as a promising therapeutic modality for allergic airway diseases, including AR. The aim of this study was to investigate the effect of rat UC-MSCs on the number of mast cells, the expression of Hsp70 indicated by the nasal symptoms allergic, particularly nasal rubbing in ovalbumininduced AR rats.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;Fifteen male Wistar rats (6 to 8 weeks old) were randomly divided into three groups (control group, sham group, and&amp;lt;br \/&amp;gt;OVA+MSCs group). OVA nasal challenge was conducted daily from day 15 to 21, and UC-MSCs (1x106&amp;lt;br \/&amp;gt;) were administrated intraperitoneally to OVA-sensitized rats on day 21. Nasal rubbing was observed from day 22 to 28. The rats were sacrificed on day 22 and day 28. The nasal cavity tissues were prepared for histological observations.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Results &amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt;The administration of UC-MSCs could reduce the number of mast cells and the expression of Hsp70 leading to reduction of&amp;lt;br \/&amp;gt;nasal symptoms allergic, particularly nasal rubbing.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusion&amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt;&amp;lt;span style=&amp;quot;background-color: var(--bs-body-bg); font-weight: var(--bs-body-font-weight); text-align: var(--bs-body-text-align);&amp;quot;&amp;gt;Based on this finding, MSCs present a promising &amp;lt;\/span&amp;gt;immediate curative effect to the inflammatory reaction in AR rats.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1421-21","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T10:28:16Z","timestamp":1713695296000},"page":"0-0","source":"Crossref","is-referenced-by-count":6,"title":["Rats\u2019 umbilical-cord mesenchymal stem cells ameliorate mast cells and Hsp70 on ovalbumin-induced allergic rhinitis rats"],"prefix":"10.17392","volume":"19","author":[{"given":"Lia","family":"Restimulia","sequence":"first","affiliation":[{"name":"Universitas Sumatera Utara","place":["Medan,Indonesia"],"department":["Departement of Doctoral Degree Program"]},{"name":"Universitas Sumatera Utara","place":["Medan,Indonesia"],"department":["Departement of Otorhinolaryngology-Head and Neck Surgery"]},{"name":"Universitas Sumatera Utara","place":["Medan,Indonesia"],"department":["Pusat Unggulan IPTEK Tissue Engineering"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syafruddin","family":"Ilyas","sequence":"additional","affiliation":[{"name":"Universitas Sumatera Utara","place":["Medan,Indonesia"],"department":["Department of Biology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delfitri","family":"Munir","sequence":"additional","affiliation":[{"name":"Universitas Sumatera Utara","place":["Medan,Indonesia"],"department":["Departement of Doctoral Degree Program"]},{"name":"Universitas Sumatera Utara","place":["Medan,Indonesia"],"department":["Pusat Unggulan IPTEK Tissue Engineering"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0346-1809","authenticated-orcid":false,"given":"Agung","family":"Putra","sequence":"additional","affiliation":[{"name":"Sultan Agung Islamic University (UNISSULA)","place":["Semarang,Indonesia"],"department":["Stem Cell and Cancer Research (SCCR)"]},{"name":"Sultan Agung Islamic University (UNISSULA)","place":["Semarang,Indonesia"],"department":["Department of Pathology"]},{"name":"Sultan Agung Islamic University (UNISSULA)","place":["Semarang,Indonesia"],"department":["Department of Postgraduate Biomedical Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teti","family":"Madiadipoera","sequence":"additional","affiliation":[{"name":"Universitas Padjadjaran\/Hasan Sadikin General Hospital","place":["Bandung,Indonesia"],"department":["Departement of Otorhinolaryngology-Head and Neck Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhat","family":"Farhat","sequence":"additional","affiliation":[{"name":"Universitas Sumatera Utara","place":["Medan,Indonesia"],"department":["Departement of Otorhinolaryngology-Head and Neck Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosita Juwita","family":"Sembiring","sequence":"additional","affiliation":[{"name":"Universitas Sumatera Utara","place":["Medan,Indonesia"],"department":["Departement of Doctoral Degree Program"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ichwan","sequence":"additional","affiliation":[{"name":"Universitas Sumatera Utara","place":["Medan,Indonesia"],"department":["Department of Pharmacology and Therapeutics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur Dina","family":"Amalina","sequence":"additional","affiliation":[{"name":"Sultan Agung Islamic University (UNISSULA)","place":["Semarang,Indonesia"],"department":["Stem Cell and Cancer Research (SCCR)"]},{"name":"Universitas Negeri Semarang","place":["Semarang,Indonesia"],"department":["Pharmacy Study Program"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"49509","published-online":{"date-parts":[[2022,2,1]]},"reference":[{"key":"ref1","first-page":"420","article-title":"Mesenchymal stromal cells ameliorate acute allergic rhinitis in rats","author":"CLiC","year":"2017","unstructured":"Li C, Fu Y, Wang Y, Kong Y, Li M, Ma D, Zhai W, \nWang H, Lin Y, Liu S, Ren F, Li J, Wang Y. 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Kinetics of thermally induced heat shock protein \n27 and 70 expression by bone marrow-derived me-\nsenchymal stem cells. Protein Sci 2012; 21:904-9.","journal-title":"Protein Sci"}],"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/219\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/219\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:44:57Z","timestamp":1775468697000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/395\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,1]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,2,1]]},"published-print":{"date-parts":[[2022,2,1]]}},"URL":"https:\/\/doi.org\/10.17392\/1421-21","archive":["Internet Archive"],"relation":{"is-cited-by":[{"id-type":"doi","id":"10.3389\/fimmu.2023.1302336","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/all.15729","asserted-by":"object"}]},"ISSN":["1840-0132","1840-0132"],"issn-type":[{"value":"1840-0132","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2,1]]}}}