{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:58:34Z","timestamp":1775473114376,"version":"3.50.1"},"reference-count":34,"publisher":"Medical Association of Zenica-Doboj","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2022,7,2]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;To analyse biochemical markers as possible predictors of death before discharge in cooled newborns following perinatal&amp;lt;br \/&amp;gt;asphyxia.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;A total of 91 infants that underwent therapeutic hypothermia after perinatal asphyxia were included. Inclusion criteria for&amp;lt;br \/&amp;gt;therapeutic hypothermia were Sarnat stage 2 or 3. Data were collected from medical histories regarding gender, gestational age, birth weight, Apgar and Sarnat score; additionally, gas analyses, liver and cardiac enzymes before, and in the first 12 hours after starting therapeutic hypothermia, were evaluated. The patients&amp;amp;rsquo; characteristics were compared between two groups, survivors and non-survivors.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Results&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;Statistical difference was not found between groups regarding gender, gestational age, birth weight, delivery type, 1st and&amp;lt;br \/&amp;gt;5th minute Apgar score, seizures, alanine aminotransferase (ALT), creatine kinase (CK), troponin and fibrinogen level. Groups were significantly different regarding acid-base balance (p=0.012), base excess (BE) (p=0.025), lactate (p=0.002), aspartate aminotransferaze (AST), (p=0.011), lactate dehydrogenase (LDH) (p=0.006), activated partial thromboplastin clotting time (aPTT) (p=0.001) and international normalized ratio (INR) (p=0.001).&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusion&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;Acid-base balance, BE, lactate, AST, LDH, aPTT and INR were significantly higher in the group of cooled newborns&amp;lt;br \/&amp;gt;after perinatal asphyxia (non-survivors), and can serve as predictors of death before discharge. Combining diagnostic modalities raises a chance for accurate prediction of outcomes of asphyxiated infants.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1447-22","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T10:28:16Z","timestamp":1713695296000},"page":"178-183","source":"Crossref","is-referenced-by-count":2,"title":["Biochemical predictors of death before discharge in cooled newborns following perinatal asphyxia"],"prefix":"10.17392","volume":"19","author":[{"given":"Sabina","family":"Terzi\u0107","sequence":"first","affiliation":[{"name":"Clinical Centre University of Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Paediatric Clinic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emina","family":"Vukas - Salihbegovi\u0107","sequence":"additional","affiliation":[{"name":"Clinical Centre University of Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Paediatric Clinic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verica","family":"Mi\u0161anovi\u0107","sequence":"additional","affiliation":[{"name":"Clinical Centre University of Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Paediatric Clinic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5964-2305","authenticated-orcid":false,"given":"Nedim","family":"Begi\u0107","sequence":"additional","affiliation":[{"name":"Clinical Centre University of Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Paediatric Clinic"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49509","published-online":{"date-parts":[[2022,7,2]]},"reference":[{"key":"ref1","first-page":"320","article-title":"Perinatal asphyxia","author":"WMcguireW","year":"2007. 2007","unstructured":"McGuire W. 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Zanelli Therape-\nutic hypothermia on neonatal transport: 4-year expe-\nrience in a single NICU. J Perinatol 2010; 30:324-9.","journal-title":"J Perinatol"},{"key":"ref17","first-page":"949","article-title":"Perinatal asphyxia with hyperoxemia within the first hour of life is associated with moderate to severe hypoxic-ischemic encephalopathy","author":"VKapadiaV","year":"2013","unstructured":"Kapadia VS, Chalak LF, DuPont TL, Rollins NK, \nBrion LP, Wyckoff MH. Perinatal asphyxia with \nhyperoxemia within the first hour of life is associa-\nted with moderate to severe hypoxic-ischemic en-\ncephalopathy. 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Clin \nMed Insights Pediatr 2015; 9:1-6.","journal-title":"Clin Med Insights Pediatr"},{"key":"ref30","first-page":"399","article-title":"Coagulation profiles are associated with early clinical outcomes in neonatal encephalopathy","author":"DSweetmanD","year":"2019","unstructured":"Sweetman D, Kelly LA, Zareen Z, Nolan B, Murphy \nJ, Boylan G, Donoghue V, Molloy EJ. Coagulation \nprofiles are associated with early clinical outcomes in \nneonatal encephalopathy. Front Pediatr 2019;7:399.","journal-title":"Front Pediatr"},{"key":"ref31","first-page":"16","article-title":"Postnatal lactate as an early predictor of short-term outcome after intrapartum asphyxia","author":"SShahS","year":"2004","unstructured":"Shah S, Tracy M, Smyth J. Postnatal lactate as an \nearly predictor of short-term outcome after intrapar-\ntum asphyxia. 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J Neonatal \nPerinatal Med 2017; 10:275-80.","journal-title":"J Neonatal Perinatal Med"},{"key":"ref34","first-page":"411","article-title":"Predictors of outcomes in hypoxic-ischemic encephalopathy following hypothermia: a meta-analysis","author":"SOuwehandS","year":"2020","unstructured":"Ouwehand S, Smidt LCA, Dudink J, Benders MJNL, \nde Vries LS, Groenendaal F, van der Aa NE. Predic-\ntors of outcomes in hypoxic-ischemic encephalo-\npathy following hypothermia: a meta-analysis. Ne-\nonatology 2020; 117:411-27.","journal-title":"Neonatology"}],"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/250\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/250\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:44:56Z","timestamp":1775468696000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/391\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,2]]},"references-count":34,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,7,2]]},"published-print":{"date-parts":[[2022,7,2]]}},"URL":"https:\/\/doi.org\/10.17392\/1447-22","archive":["Internet Archive"],"relation":{},"ISSN":["1840-0132","1840-0132"],"issn-type":[{"value":"1840-0132","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7,2]]}}}