{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:57:41Z","timestamp":1775473061036,"version":"3.50.1"},"reference-count":27,"publisher":"Medical Association of Zenica-Doboj","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2022,7,2]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim &amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt;Given the impact of vascular comorbidities (VC) on the diagnosis, treatment, and outcome of multiple sclerosis (MS), we&amp;lt;br \/&amp;gt;examined the incidence and correlation of VC and risk factors for vascular disease in people with MS (PwMS) compared to the general population, and the impact on the physical disability of patients.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;Cross-sectional study involved 100 patients with MS and 50 healthy people from the general population, matched by&amp;lt;br \/&amp;gt;sex and age. The values of demographic, biochemical, and anthropometric parameters, the presence of VC and risk factors for vascular diseases in both groups, and clinical parameters in PwMS were analysed. Statistical analysis included methods of descriptive statistics, &amp;amp;chi;2 test, Student&amp;#039;s t-test, analysis of variance, correlation&amp;lt;br \/&amp;gt;and regression analysis.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Results&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;Groups differed by a higher frequency of transient ischemic attack in the control group (p=0.024), and the treatment of&amp;lt;br \/&amp;gt;hypertension (p=0.038) and smoking frequency (p=0.044) in the MS group. Normal triglycerides levels were statistically significantly more prevalent in the MS group (p=0.000). Total body weight and BMI were statistically significantly higher in the control group (p=0.000). The increase in Expanded Disability Status Scale (EDSS) score was associated with higher levels of total (p=0.001) and low-density lipoprotein (LDL) cholesterol (p=0.003), and activated partial thromboplastin time APTT (p=0.002).&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusion&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;In PwMS it is necessary to pay attention to the higher frequency of smoking than in general population, and the impact&amp;lt;br \/&amp;gt;of total cholesterol, LDL and APTT levels as significant parameters that affect physical disability.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1499-22","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T10:28:16Z","timestamp":1713695296000},"page":"166-172","source":"Crossref","is-referenced-by-count":1,"title":["Vascular comorbidities in patients with multiple sclerosis and their impact on physical disability"],"prefix":"10.17392","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6207-7906","authenticated-orcid":false,"given":"Daliborka","family":"Tadi\u0107","sequence":"first","affiliation":[{"name":"University Clinical Centre of the Republic of Srpska","place":["Banjaluka,Bosnia and Herzegovina"],"department":["Clinic of Neurology"]},{"name":"School of Medicine, University of Banja Luka","place":["Banjaluka,Bosnia and Herzegovina"],"department":["Department of Neurology"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanja","family":"Grgi\u0107","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Banja Luka","place":["Banjaluka,Bosnia and Herzegovina"],"department":["Department of Neurology"]},{"name":"University Clinical Centre of the Republic of Srpska","place":["Banjaluka,Bosnia and Herzegovina"],"department":["Clinic of Neurology"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Dominovi\u0107-Kova\u010devi\u0107","sequence":"additional","affiliation":[{"name":"University Clinical Centre of the Republic of Srpska","place":["Banjaluka,Bosnia and Herzegovina"],"department":["Clinic of Neurology"]},{"name":"School of Medicine, University of Banja Luka","place":["Banjaluka,Bosnia and Herzegovina"],"department":["Department of Neurology"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majda","family":"Nazalevi\u0107-Bursa\u0107","sequence":"additional","affiliation":[{"name":"University Clinical Centre of the Republic of Srpska","place":["Banjaluka,Bosnia and Herzegovina"],"department":["Clinic of Neurology"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sr\u0111an","family":"Mavija","sequence":"additional","affiliation":[{"name":"University Clinical Centre of the Republic of Srpska","place":["Banja Luka,Bosnia and Herzegovina"],"department":["Clinic of Neurology"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vlado","family":"\u0110aji\u0107","sequence":"additional","affiliation":[{"name":"University Clinical Centre of the Republic of Srpska","place":["Banja Luka,Bosnia and Herzegovina"],"department":["Clinic of Neurology"]},{"name":"School of Medicine, University of Banja Luka","place":["Banja Luka,Bosnia and Herzegovina"],"department":["Department of Neurology"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49509","published-online":{"date-parts":[[2022,7,2]]},"reference":[{"key":"ref1","first-page":"419","article-title":"Effects of physical comorbidities on disability progression in multiple sclerosis","author":"TZhangT","year":"2018","unstructured":"Zhang T, Tremlett H, Zhu F, Kingwell E, Fisk JD, \nBhan V, Campbell T, Stadnyk K, Carruthers R, Wolf-\nson C, Warren S, Marrie RA. Effects of physical \ncomorbidities on disability progression in multiple \nsclerosis. Neurology 2018; 90:e419-27.","journal-title":"Neurology"},{"key":"ref2","first-page":"41249","article-title":"Quality of life in adults with multiple sclerosis: a systematic review","author":"IGil-Gonz\u00e1lezI","year":"2020","unstructured":"Gil-Gonz\u00e1lez I, Mart\u00edn-Rodr\u00edguez A, Conrad R, \nP\u00e9rez-San-Gregorio M\u00c1. Quality of life in adults \nwith multiple sclerosis: a systematic review. BMJ \nOpen 2020; 10:e041249.","journal-title":"BMJ Open"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3389\/fneur.2020.00851","article-title":"Comorbidity in multiple sclerosis","author":"MMagyariM","year":"2020","unstructured":"Magyari M, Sorensen PS. Comorbidity in multiple \nsclerosis. Front Neurol 2020; 11:851.","journal-title":"Front Neurol"},{"key":"ref4","first-page":"4066","article-title":"A global view of comorbidity in multiple sclerosis: a systematic review with a focus on regional differences, methodology, and clinical implications","author":"LHauerL","year":"2021","unstructured":"Hauer L, Perneczky J, Sellner J. A global view of co-\nmorbidity in multiple sclerosis: a systematic review \nwith a focus on regional differences, methodology, \nand clinical implications. J Neurol 2021; 268:4066-77.","journal-title":"J Neurol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"103558","DOI":"10.1016\/j.msard.2022.103558","article-title":"Comorbidity in multiple sclerosis: Emphasis on patient-reported outcomes","author":"BDir\u017eiuvien\u0117B","year":"2022","unstructured":"Dir\u017eiuvien\u0117 B, Mickevi\u010dien\u0117 D. Comorbidity in \nmultiple sclerosis: Emphasis on patient-reported \noutcomes. Mult Scler Relat Disord 2022; 59:103558.","journal-title":"Mult Scler Relat Disord"},{"key":"ref6","first-page":"140","article-title":"ACC\/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","author":"DArnettD","year":"2019","unstructured":"Arnett DK, Blumenthal RS, Albert MA, Buroker \nAB, Goldberger ZD, Hahn EJ, Himmelfarb CD, \nKhera A, Lloyd-Jones D, McEvoy JW, Michos ED, \nMiedema MD, Mu\u00f1oz D, Smith SC Jr, Virani SS, \nWilliams KA Sr, Yeboah J, Ziaeian B. ACC\/AHA \nGuideline on the Primary Prevention of Cardiovas-\ncular Disease: A Report of the American College of \nCardiology\/American Heart Association Task Force \non Clinical Practice Guidelines. Circulation 2019; \n10:140:e596-646.","journal-title":"Circulation"},{"key":"ref7","first-page":"1444","article-title":"Rating neurologic instrument in multiple sclerosis: An expanded disability status scale (EDSS)","author":"JKurtzkeJ","year":"1983","unstructured":"Kurtzke JF. Rating neurologic instrument in mul-\ntiple sclerosis: An expanded disability status scale \n(EDSS). Neurology 1983; 33:1444-52.","journal-title":"Neurology"},{"key":"ref8","first-page":"1190","article-title":"Oxysterols and apolipoproteins in multiple sclerosis: a 5-year follow-up study","author":"MFellowsM","year":"2019","unstructured":"Fellows MK, Bhattacharya S, Bodziak ML, Jakimov-\nski D, Hagemeier J, Browne RW, Weinstock-Guttman \nB, Zivadinov R, Ramanathan M. Oxysterols and apo-\nlipoproteins in multiple sclerosis: a 5-year follow-up \nstudy. J Lipid Res 2019; 60:1190-98.","journal-title":"J Lipid Res"},{"key":"ref9","first-page":"225","article-title":"Apolipoproteins C-II and C-III as nutritional markers unaffected by inflammation","author":"MIsshikiM","year":"2018","unstructured":"Isshiki M, Hirayama S, Ueno T, Ito M, Furuta A, \nYano K, Yamatani K, Sugihara M, Idei M, Miida \nT. Apolipoproteins C-II and C-III as nutritional mar-\nkers unaffected by inflammation. Clin Chim Acta \n2018; 481:225-30.","journal-title":"Clin Chim Acta"},{"key":"ref10","first-page":"475","article-title":"Comorbidities in patients with multiple sclerosis in Croatia","author":"Bo\u0161njakPa\u0161i\u0107Bo\u0161njak","year":"2021","unstructured":"Bo\u0161njak Pa\u0161i\u0107 M, Tudor KI, Musta\u010d F, Raji\u010d F, Pa\u0161i\u0107 \nH, Vujevi\u0107 L, \u0160arac H, Vidrih B. Comorbidities in \npatients with multiple sclerosis in Croatia. Psychiatr \nDanub 2021; 33:475-79.","journal-title":"Psychiatr Danub"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"693440","DOI":"10.3389\/fneur.2021.693440","article-title":"Onset symptom clusters in multiple sclerosis: characteristics, comorbidities, and risk factors","author":"VAjdacic-GrossV","year":"2021","unstructured":"Ajdacic-Gross V, Steinemann N, Horv\u00e1th G, Rod-\ngers S, Kaufmann M, Xu Y, Kamm CP, Kesselring J, \nManjaly ZM, Zecca C, Calabrese P, Puhan MA, von \nWyl V. Onset symptom clusters in multiple sclerosis: \ncharacteristics, comorbidities, and risk factors. Front \nNeurol 2021; 12:693440.","journal-title":"Front Neurol"},{"key":"ref12","first-page":"41","article-title":"Body composition and disability in people with multiple sclerosis. A dual energy x-ray absorptiometry study","author":"LPilutiL","year":"2019","unstructured":"Piluti LA, Molti RW. Body composition and disabi-\nlity in people with multiple sclerosis. A dual energy \nx-ray absorptiometry study. Mult Scler Relat Disord \n2019; 29:41-47.","journal-title":"Mult Scler Relat Disord"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2217\/nmt-2018-0046","article-title":"Lifestyle-based modifiable risk factors in multiple sclerosis: review of experimental and clinical findings","author":"DJakimovskiD","year":"2019","unstructured":"Jakimovski D, Guan Y, Ramanathan M, Weinstock-\nGuttman B, Zivadinov R. Lifestyle-based modifiable \nrisk factors in multiple sclerosis: review of experi-\nmental and clinical findings. Neurodegener Dis Ma-\nnag 2019; 9:149-72.","journal-title":"Neurodegener Dis Manag"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1177\/1352458518801727","article-title":"Smoking and its interaction with genetics in MS etiology","author":"AHedstr\u00f6mA","year":"2019","unstructured":"Hedstr\u00f6m AK. Smoking and its interaction with ge-\nnetics in MS etiology. 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Smoking is not associated \nwith higher prevalence of JC virus in MS patients. \nEur J Clin Microbiol Infect Dis 2018; 37:907-10.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"ref18","first-page":"1298","article-title":"Smoking is associated with increased disease activity during natalizumab treatment in multiple sclerosis","author":"ABang OturaiA","year":"2018","unstructured":"A Bang Oturai A, Sellebjerg F, S\u00f8ndergaard HB, \nSoelberg S\u00f8rensen P, Olsson AG, Laursen JH. Smo-\nking is associated with increased disease activity \nduring natalizumab treatment in multiple sclero-\nsis. Mult Scler J 2018; 25:1298-305.","journal-title":"Mult Scler J"},{"key":"ref19","first-page":"2316","article-title":"Current evidence on the efficacy of gluten-free diets in multiple sclerosis, psoriasis, type 1 diabetes and autoimmune thyroid diseases","author":"MPassaliM","year":"2020","unstructured":"Passali M, Josefsen K, Frederiksen JL, Antvorskov \nJC. Current evidence on the efficacy of gluten-free \ndiets in multiple sclerosis, psoriasis, type 1 diabetes \nand autoimmune thyroid diseases. Nutrients 2020; \n12:2316.","journal-title":"Nutrients"},{"key":"ref20","first-page":"999","article-title":"Wellness and the role of comorbidities in multiple sclerosis","author":"BMossB","year":"2017","unstructured":"Moss BP, Rensel MR, Hersh CM. Wellness and the \nrole of comorbidities in multiple sclerosis. Neu-\nrotherapeutics 2017; 14:999-1017.","journal-title":"Neurotherapeutics"},{"key":"ref21","first-page":"1417","article-title":"CIHR Team in the Epidemiology and Impact of Comorbidity on Multiple Sclerosis (ECoMS). Healthrelated quality of life in multiple sclerosis: direct and indirect effects of comorbidity","author":"LBerriganL","year":"2016","unstructured":"Berrigan LI, Fisk JD, Patten SB, Tremlett H, Wolf-\nson C, Warren S, Fiest KM, McKay KA, Marrie RA, \nCIHR Team in the Epidemiology and Impact of Co-\nmorbidity on Multiple Sclerosis (ECoMS). Health-\nrelated quality of life in multiple sclerosis: direct \nand indirect effects of comorbidity. Neurology 2016; \n86:1417-24.","journal-title":"Neurology"},{"key":"ref22","first-page":"820","article-title":"Evaluating the risk of macrovascular events and mortality among people with multiple sclerosis in England","author":"RPalladinoR","year":"2020","unstructured":"Palladino R, Marrie RA, Majeed A, Chataway J. \nEvaluating the risk of macrovascular events and \nmortality among people with multiple sclerosis in \nEngland. JAMA Neurol 2020; 77:820-28.","journal-title":"JAMA Neurol"},{"key":"ref23","first-page":"1095","article-title":"Multidatabase study of multiple sclerosis: identification, validation and description of MS patients in two countries","author":"RPerssonR","year":"2019","unstructured":"Persson R, Lee S, Yood MU, Wagner M, Minton N, \nNiemcryk S, Lindholm A, Evans A, Jick S. Multi-\ndatabase study of multiple sclerosis: identification, \nvalidation and description of MS patients in two co-\nuntries. J Neurol 2019; 266:1095-106.","journal-title":"J Neurol"},{"key":"ref24","first-page":"12","article-title":"Safety of newer disease modifying therapies in multiple sclerosis","author":"GJalkhG","year":"2020","unstructured":"Jalkh G, Abi Nahed R, Macaron G, Rensel M. Safety \nof newer disease modifying therapies in multiple \nsclerosis. Vaccines 2020; 9:12.","journal-title":"Vaccines"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1177\/1352458519853473","article-title":"Obesity worsens central inflammation and disability in multiple sclerosis","author":"BStampanoniB","year":"2020","unstructured":"Stampanoni BM, Iezzi E, Buttari F, Gilio L, Simo-\nnelli I, Carbone F, Micillo T, De Rosa V, Sica F, Fur-\nlan R, Finardi A, Fantozzi R, Storto M, Bellantonio \nP, Pirollo P, Di Lemme S, Musella A, Mandolesi G, \nCentonze D, Matarese G. Obesity worsens central \ninflammation and disability in multiple sclerosis. \nMult Scler 2020; 26:1237-46.","journal-title":"Mult Scler"},{"key":"ref26","first-page":"409","article-title":"Coagulation pathways in neurological diseases: multiple sclerosis","author":"NZiliottoN","year":"2019","unstructured":"Ziliotto N, Bernardi F, Jakimovski D, Zivadinov R. \nCoagulation pathways in neurological diseases: mul-\ntiple sclerosis. Front Neurol 2019; 10:409.","journal-title":"Front Neurol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"548604","DOI":"10.3389\/fimmu.2020.548604","article-title":"Coagulation\/complement activation and cerebral hypoperfusion in relapsing-remitting multiple sclerosis","author":"TKoudriavtsevaT","year":"2020","unstructured":"Koudriavtseva T, Stefanile A, Fiorelli M, Lapucci \nC, Lorenzano S, Zannino S, Conti L, D'Agosto G, \nPimpinelli F, Di Domenico EG, Mandoj C, Gianna-\nrelli D, Donzelli S, Blandino G, Salvetti M, Inglese \nM. Coagulation\/complement activation and cerebral \nhypoperfusion in relapsing-remitting multiple scle-\nrosis. Front Immunol 2020; 11:548604.","journal-title":"Front Immunol"}],"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/179\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/179\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:44:19Z","timestamp":1775468659000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/241\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,2]]},"references-count":27,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,7,2]]},"published-print":{"date-parts":[[2022,7,2]]}},"URL":"https:\/\/doi.org\/10.17392\/1499-22","archive":["Internet Archive"],"relation":{},"ISSN":["1840-0132","1840-0132"],"issn-type":[{"value":"1840-0132","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7,2]]}}}