{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:57:22Z","timestamp":1775473042840,"version":"3.50.1"},"reference-count":22,"publisher":"Medical Association of Zenica-Doboj","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2022,8,27]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim &amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt;To analyse the association of human leukocyte antigen B27 with clinical and laboratory parameters in patients with juvenile&amp;lt;br \/&amp;gt;idiopathic arthritis (JIA) at the disease onset.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods &amp;lt;br \/&amp;gt;&amp;lt;\/strong&amp;gt;A retrospective review of medical records of 25 HLAB27 positive and 25 HLA-B27 negative JIA patients was performed. The diagnosis of JIA was based on the 1997-2001 International League Against Rheumatism (ILAR) criteria. Collected data:&amp;lt;br \/&amp;gt;age, sex, HLA- B27 antigen presence, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid-factor (RF), antinuclear antibody (ANA), fever, rash, uveitis, enthesitis, inflamed joints and subtype of JIA.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Results&amp;lt;\/strong&amp;gt;&amp;lt;br \/&amp;gt;HLA- B27 positive study group had more boys (p=0.01), higher erythrocyte sedimentation rate (p=0.038), higher presence&amp;lt;br \/&amp;gt;of fever (p= 0.025) and enthesitis (p=0.024). Any significant difference in age of the disease onset, CRP, ANA, RF, rash, uveitis, inflamed joint and dactylitis was not noticed. The most common subtype of JIA in the HLA-B27 positive patients was ERA (60%).&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusion&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;This study showed that the presence of HLA- B27 antigen plays a significant role in determining the presenting clinical&amp;lt;br \/&amp;gt;and laboratory characteristics in JIA patients.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1556-22","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T10:28:16Z","timestamp":1713695296000},"page":"580-62","source":"Crossref","is-referenced-by-count":1,"title":["Association of HLA-B27 antigen with clinical and laboratory parameters in patients with juvenile idiopathic arthritis"],"prefix":"10.17392","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5964-2305","authenticated-orcid":false,"given":"Adisa","family":"\u010cengi\u0107","sequence":"first","affiliation":[{"name":"Clinical Centre University of Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Paediatric Clinic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Velma","family":"Selmanovi\u0107","sequence":"additional","affiliation":[{"name":"Clinical Centre University of Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Paediatric Clinic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Snije\u017eana","family":"Hasanbegovi\u0107","sequence":"additional","affiliation":[{"name":"Clinical Centre University of Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Paediatric Clinic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nedim","family":"Begi\u0107","sequence":"additional","affiliation":[{"name":"Clinical Centre University of Sarajevo","place":["Sarajevo,Bosnia and Herzegovina"],"department":["Paediatric Clinic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emina","family":"Kar\u010di\u0107","sequence":"additional","affiliation":[{"name":"Cantonal Hospital Zenica","place":["Zenica,Bosnia and Herzegovina"],"department":["Department of Paediatrics"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elma","family":"Fejzi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine of the Federation of Bosnia and Herzegovina","place":["Sarajevo,Bosnia and Herzegovina"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49509","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"ref1","first-page":"206","article-title":"Textbook of Pediatric Rheumatology","author":"JCassidyJ","year":"2005","unstructured":"Cassidy JT, Pett RE. 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Mol Med Rep 2017; 15:1943-51.","journal-title":"Mol Med Rep"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1546-0096-8-26","article-title":"HLA B27 allele types in homogeneous groups of juvenile idiopathic arthritis patients in Latvia","author":"VStanevichaV","year":"2010","unstructured":"Stanevicha V, Eglite J, Zavadska D, Sochnevs A, La-\nzareva A, Guseinova D, Shantere R, Gardovska D. \nHLA B27 allele types in homogeneous groups of ju-\nvenile idiopathic arthritis patients in Latvia. Pediatr \nRheumatol Online J 2010; 8:26.","journal-title":"Pediatr Rheumatol Online J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.5114\/reum.2015.53133","article-title":"Prevalence of HLA-B27 antigen in patients with juvenile idiopathic arthritis","author":"Z\u017buberZ","year":"2015","unstructured":"\u017buber Z, Turowska-Heydel D, Sobczyk M, Chudek \nJ. Prevalence of HLA-B27 antigen in patients with \njuvenile idiopathic arthritis. 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Pediatr Rheumatol Online J 2018; \n16-21.","journal-title":"Pediatr Rheumatol Online J"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1007\/s00296-016-3529-9","article-title":"HLA B27 typing in 511 children with juvenile idiopathic arthritis from India","author":"RSrivastavaR","year":"2016","unstructured":"Srivastava R, Phatak S, Yadav A, Bajpai P, Aggarwal \nA. HLA B27 typing in 511 children with juvenile \nidiopathic arthritis from India. Rheumatol Int 2016; \n36:1407-11.","journal-title":"Rheumatol Int"},{"key":"ref13","first-page":"725","article-title":"HLA-B27 predicts a more chronic disease course in an 8-year follow up cohort of patients with juvenile idiopathic arthritis","author":"LBerntsonL","year":"2013","unstructured":"Berntson L, Nordal E, Aalto K. HLA-B27 predicts a \nmore chronic disease course in an 8-year follow up \ncohort of patients with juvenile idiopathic arthritis. 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Arthritis Rheumatol \n2015; 67:10.","journal-title":"Arthritis Rheumatol"}],"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/267\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/267\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:44:03Z","timestamp":1775468643000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/197\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,27]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,8,27]]},"published-print":{"date-parts":[[2022,8,27]]}},"URL":"https:\/\/doi.org\/10.17392\/1556-22","archive":["Internet Archive"],"relation":{},"ISSN":["1840-0132","1840-0132"],"issn-type":[{"value":"1840-0132","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8,27]]}}}