{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:57:04Z","timestamp":1785405424685,"version":"3.56.0"},"reference-count":37,"publisher":"Medical Association of Zenica-Doboj","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;To investigate the serum value of brain derived neurotrophic factor (BDNF), proteins S-100, NSE, IL-6 in normal pressure patients (NPH) compared to control (healthy) group and also a possible correlation with radiological findings in NPH patients.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;Study patients were included during the period of 2020-2022. All NPH patients met the diagnostic criteria for probability&amp;lt;br \/&amp;gt;of NPH. Control patients group included patients without known brain disorder, without clinical symptoms of NPH. Blood samples were taken before planned surgery for NPH. BDNF serum concentrations were assessed by a sensitive ELISA kit, and serum concentrations of S-100, NSE and IL-6 were assessed by using ECLIA technology for immunoassay detection.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Results&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;Among 15 patients who were included, seven NPH patients were compared to eight control patients. Non-significant&amp;lt;br \/&amp;gt;decrease in BDNF serum concentrations, an increase of protein S-100 serum concentrations, a decrease of NSE serum concentrations, as well as an increase of IL-6 serum concentrations in NPH patients compared to healthy controls was found. Strong positive correlation between BNDF and Evans index was observed (p=0.0295).&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusion&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;We did not find a significant difference of BDNF, protein S-100, IL-6 and NSE between serum concentration in NPH&amp;lt;br \/&amp;gt;and healthy patients. More future research is needed to find the&amp;lt;br \/&amp;gt;role of BDNF in NPH patients.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1590-23","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T10:28:16Z","timestamp":1713695296000},"page":"235-241","source":"Crossref","is-referenced-by-count":1,"title":["Serum biomarkers in normal pressure hydrocephalus"],"prefix":"10.17392","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0858-4621","authenticated-orcid":false,"given":"Enra","family":"Mehmedika-Sulji\u0107","sequence":"first","affiliation":[{"name":"Clinical Centre University of Sarajevo","department":["Department of Neurology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebija","family":"Izetbegovi\u0107","sequence":"additional","affiliation":[{"name":"Clinical Centre University of Sarajevo","department":["Department of Gynaecology and Obstetrics"]},{"name":"University of Sarajevo","department":["School of 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