{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:57:18Z","timestamp":1775473038726,"version":"3.50.1"},"reference-count":29,"publisher":"Medical Association of Zenica-Doboj","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;To determine the relationship between coagulation disorders and septic condition in COVID-19 critically ill patients.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;Data from 99 patients who presented with COVID-19 acute hypoxemic respiratory failure (CAHRF) were divided into&amp;lt;br \/&amp;gt;two groups: Group 1- patients who developed sepsis, and Group 2 - patients who developed septic shock. Age, sex, comorbidities, quick Sequential Organ Failure Assessment (qSOFA) score, vasopressor and inotrope requirement, laboratory findings (platelets, neutrophils, lymphocytes, procalcitonin - PCT, C-reactive protein, fibrinogen, D-dimer, sepsis-induced coagulopathy &amp;amp;ndash; SIC, and disseminated intravascular coagulation - DIC score) were recorded on the day of admission and on the day of starting invasive mechanical ventilation. The primary outcome was to establish&amp;lt;br \/&amp;gt;COVID-19 associated coagulopathy with sepsis and septic shock; the secondary outcome measure was incidence of coagulopathy in septic COVID-19 critically ill patients.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Results&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;The most common coagulation abnormality was international normalized ratio (INR) (p=0.019) for Group 2, followed&amp;lt;br \/&amp;gt;by the values of inflammatory parameters PCT (p=0.002) and lymphocytes (p=0.011) also for Group 2. The statistical significance of SIC score was observed for both groups (p=0.007) and p=0.012, respectively. Norepinephrine (p=0.000) and dobutamine (p=0.000) for Group 2, qSOFA for both groups (p = 0.000) were&amp;lt;br \/&amp;gt;statistically significant.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusion&amp;lt;\/strong&amp;gt; &amp;lt;br \/&amp;gt;The observed coagulation abnormalities met the criteria for a SIC diagnosis, therefore, the management of coagulation&amp;lt;br \/&amp;gt;disorders at this stage of the disease should follow the management of a septic condition.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1592-23","type":"journal-article","created":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T10:28:16Z","timestamp":1713695296000},"page":"142-147","source":"Crossref","is-referenced-by-count":0,"title":["COVID-19 associated coagulopathy in septic critically ill patients - a retrospective cohort study"],"prefix":"10.17392","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3492-4100","authenticated-orcid":false,"given":"Mirza","family":"Kova\u010devi\u0107","sequence":"first","affiliation":[{"name":"Cantonal Hospital Zenica","place":["Zenica,Bosnia and Herzegovina"],"department":["Department of Anaesthesiology, Resuscitation and Intensive Care"]},{"name":"University of Zenica","place":["Zenica,Bosnia and Herzegovina"],"department":["School of Medicine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nermina","family":"Rizvanovi\u0107","sequence":"additional","affiliation":[{"name":"Cantonal Hospital Zenica","place":["Zenica,Bosnia and Herzegovina"],"department":["Department of Anaesthesiology, Resuscitation and Intensive Care"]},{"name":"University of Zenica","place":["Zenica,Bosnia and Herzegovina"],"department":["School of Medicine"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adisa","family":"\u0160abanovi\u0107 Adilovi\u0107","sequence":"additional","affiliation":[{"name":"University of Zenica","place":["Zenica,Bosnia and Herzegovina"],"department":["School of Medicine"]},{"name":"Cantonal Hospital Zenica","place":["Zenica,Bosnia and Herzegovina"],"department":["Department of Anaesthesiology, Resuscitation and Intensive Care"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senada","family":"\u010cau\u0161evi\u0107","sequence":"additional","affiliation":[{"name":"Cantonal Hospital Zenica","place":["Zenica,Bosnia and Herzegovina"],"department":["Department of Anaesthesiology, Resuscitation and Intensive Care"]},{"name":"University of Zenica","place":["Zenica,Bosnia and Herzegovina"],"department":["School of Medicine"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49509","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"899\u2013911","DOI":"10.1080\/00325481.2021.1974212","article-title":"Nuts 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