{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:59:02Z","timestamp":1775473142678,"version":"3.50.1"},"reference-count":0,"publisher":"Medical Association of Zenica-Doboj","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim&amp;lt;\/strong&amp;gt; To evaluate the essential role of Moringa-albumin (MA) formulation in the maintenance of complement regulatory proteins through CD55 and CD59 on erythrocyte (TER-119).&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods&amp;lt;\/strong&amp;gt; Strepto-zotocin (145 mg\/kg) was used to induce diabetes mice. In diabetes mellitus (DM) model mice were treated with MA formulation for 14 days at a D1 - 500 mg\/kg (M) + 620 mg\/kg BW (A), D2 - 1000 mg\/kg (M) + 420 mg\/kg (A), and D3 - 1500 mg\/kg (M) + 200 mg\/kg (A). On the 15th day, the mice were dissected for the isolation of their bone marrow by the flushing method. The analysis flow cytometry was performed to find out the TER-119, CD55, and CD59 expressions. The data were statistically analyzed with one-way ANOVA (&amp;amp;rho;&amp;amp;le; 0.05) and Tukey test using SPSS version 16 for Windows.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Results&amp;lt;\/strong&amp;gt; The effect of MA administration in D3 group have a significant effect on increasing the profile of erythrocytes (TER-119), compared to DM (&amp;amp;rho;&amp;amp;le;0.05) group (STZ Injection-no treatment), as well as CD59 expressed by erythrocytes. MA administration in D1 group and D3 group significantly increased the profile of CD55 expressed by erythrocytes compared to DM (&amp;amp;rho;&amp;amp;le;0.05).&amp;amp;nbsp;&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusions&amp;lt;\/strong&amp;gt; MA formulation with D3 group (1500 mg\/kg (M) + 200 mg\/kg (A)) was able to maintain or control complement regula-tory proteins (CD55 and CD59) on red blood cells (erythro-cytes\/TER-119) in DM.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1685-21-02","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T07:01:00Z","timestamp":1721804460000},"page":"391-397","source":"Crossref","is-referenced-by-count":0,"title":["Essential role of Moringa-albumin (MA) formulation in the maintenance of complement regulatory proteins on erythrocyte (TER-119) cells in diabetic mouse models"],"prefix":"10.17392","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6987-6295","authenticated-orcid":false,"given":"Noviana","family":"Dwi Lestari","sequence":"first","affiliation":[{"name":"Medical Education Study Program, Faculty of Medicine, Muhammadiyah Malang University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sulistyo","family":"Mulyo Agustini","sequence":"additional","affiliation":[{"name":"Department of Pathology; Faculty of Medicine, Muhammadiyah Malang University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moh","family":"Dliyauddin","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University; Malang, East Java"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wahyu","family":"Isnia Adharini","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University; Malang, East Java"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruri","family":"Vivian Nilamsari","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University; Malang, East Java"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nashi","family":"Widodo","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University; Malang, East Java"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sri","family":"Rahayu","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University; Malang, East Java"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhaimin","family":"Rifa\u2019i","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University; Malang, East Java"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49509","published-online":{"date-parts":[[2024,9,1]]},"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/1904\/pdf\/download","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/1904\/pdf\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:45:16Z","timestamp":1775468716000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/465\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,9,1]]},"published-print":{"date-parts":[[2024,9,1]]}},"URL":"https:\/\/doi.org\/10.17392\/1685-21-02","archive":["Internet Archive"],"relation":{},"ISSN":["1840-0132","1840-0132"],"issn-type":[{"value":"1840-0132","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9,1]]}}}