{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:59:10Z","timestamp":1775473150066,"version":"3.50.1"},"reference-count":0,"publisher":"Medical Association of Zenica-Doboj","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicinski Glasnik"],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:p>&amp;lt;p&amp;gt;&amp;lt;strong&amp;gt;Aim &amp;lt;\/strong&amp;gt;To determine the effect of body mass index (BMI) and waist-hip ratio (WHR) on the concentration of circulating sex hormone-binding globulin (SHBG) throughout the menopausal transition.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Methods &amp;lt;\/strong&amp;gt;This cross-sectional study included 150 women divided into three groups: premenopausal (n=50), perimenopausal (n=50), and postmenopausal (n=50). The processing of the test women consisted of three phases: inter-view, blood sampling and determination of BMI and WHR. The SHBG concentration was determined from the blood, and BMI and WHR were measured.&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Results &amp;lt;\/strong&amp;gt;The BMI and WHR of the post-menopausal women were significantly higher comparing to the other two groups, while the postmenopausal SHBG was significantly lower compared to the premenopausal con-centration. In all three groups, a significant negative correlation was found between SHBG and BMI (Rho= -0.385; p&amp;amp;lt;0.05), and between SHBG and WHR (Rho= -0.411; p&amp;amp;lt;0.05). By the univariate regression analysis model, it was determined that BMI (&amp;amp;beta;= -0.594; p&amp;amp;lt;0.001) and WHR (&amp;amp;beta;= -0.407; p=0.003) were independently negative predictors of SHBG in postmenopausal women, while in the multivariate regression analysis model only BMI as an independently negative predictor of SHBG in postmenopausal women was found (&amp;amp;beta;= -0.263; p=0.024).&amp;lt;br \/&amp;gt;&amp;lt;strong&amp;gt;Conclusion &amp;lt;\/strong&amp;gt;The value of SHBG during the menopausal transition decreases and women with higher BMI and WHR have lower values of SHBG regardless of the duration of menopause.&amp;amp;nbsp;&amp;lt;br \/&amp;gt;Considering the connection between SHBG and anthropometric parameters, and the drop in its values upon entering and passing through the menopausal transition as such it can be used as a predictor for an increased risk of cardiovascular diseases and metabolic syndrome in a selected group of women.&amp;lt;\/p&amp;gt;<\/jats:p>","DOI":"10.17392\/1751-21-02","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T10:11:50Z","timestamp":1724321510000},"page":"344-348","source":"Crossref","is-referenced-by-count":0,"title":["The influence of anthropometric parameters on the concentration of globulin that binds sex hormones during the menopausal transition"],"prefix":"10.17392","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8326-456X","authenticated-orcid":false,"given":"D\u017eenana","family":"Softi\u0107","sequence":"first","affiliation":[{"name":"Department of Gynaecology and Obstetrics, University Clinical Centre Tuzla"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lejla","family":"Me\u0161ali\u0107","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Tuzla; Tuzla"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delila","family":"Softi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Emergency Medical Assistance of Canton Sarajevo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"49509","published-online":{"date-parts":[[2024,9,1]]},"container-title":["Medicinski Glasnik"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/medicinskiglasnik.ba\/article\/1937\/pdf\/download","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/medicinskiglasnik.ba\/article\/1937\/pdf\/download","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:45:19Z","timestamp":1775468719000},"score":1,"resource":{"primary":{"URL":"https:\/\/medicinskiglasnik.ba\/article\/id\/477\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,9,1]]},"published-print":{"date-parts":[[2024,9,1]]}},"URL":"https:\/\/doi.org\/10.17392\/1751-21-02","archive":["Internet Archive"],"relation":{},"ISSN":["1840-0132","1840-0132"],"issn-type":[{"value":"1840-0132","type":"electronic"},{"value":"1840-0132","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9,1]]}}}